Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGFR4
  • Mouse genes Fgfr4
  • Rat genes Fgfr4
  • Zfish genes fgfr4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgfr4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0017134	fibroblast growth factor binding	FGFR4	IPI	UniProtKB:O95750	Human	PMID:10525310
Molecular Function	GO:0017134	fibroblast growth factor binding	FGFR4	IPI	UniProtKB:O95750	Human	PMID:17627937
Molecular Function	GO:0017134	fibroblast growth factor binding	FGFR4	IDA		Human	PMID:18480409
Molecular Function	GO:0017134	fibroblast growth factor binding	FGFR4	IDA		Human	PMID:8663044
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	FGFR4	IGI	UniProtKB:O95750	Human	PMID:10525310
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	FGFR4	IDA		Human	PMID:18480409
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	FGFR4	IDA		Human	PMID:21653700
Molecular Function	GO:0005007	fibroblast growth factor receptor activity	FGFR4	IDA		Human	PMID:8663044
Molecular Function	GO:0008201	heparin binding	FGFR4	IDA		Human	PMID:18480409
Molecular Function	GO:0005515	protein binding	FGFR4	IPI	UniProtKB:Q86Z14	Human	PMID:17627937
Molecular Function	GO:0005515	protein binding	FGFR4	IPI	UniProtKB:P50281	Human	PMID:20798051
Molecular Function	GO:0005515	protein binding	FGFR4	IPI	UniProtKB:P07949	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	FGFR4	IPI	UniProtKB:P11362	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Fgfr4	IPI	UniProtKB:O35082	Mouse	MGI:MGI:4420739|PMID:19966287
Molecular Function	GO:0005515	protein binding	Fgfr4	IPI	UniProtKB:Q99N32	Mouse	MGI:MGI:3709813|PMID:17452648
Molecular Function	GO:0005515	protein binding	Fgfr4	IPI	PR:O35082	Mouse	PMID:16436388
Molecular Function	GO:0005515	protein binding	fgfr4	IPI	UniProtKB:A4JYD4	Zfish	PMID:18296487
Molecular Function	GO:0005515	protein binding	fgfr4	IPI	UniProtKB:Q7SX76	Zfish	PMID:18296487
Molecular Function	GO:0005515	protein binding	fgfr4	IPI	UniProtKB:A8BBG3	Zfish	PMID:19765300
Molecular Function	GO:0005515	protein binding	fgfr4	IPI	UniProtKB:A4JYG1	Zfish	PMID:18296487
Cellular Component	GO:0005911	cell-cell junction	FGFR4	IDA		Human	PMID:20798051
Cellular Component	GO:0005783	endoplasmic reticulum	FGFR4	IDA		Human	PMID:20683963
Cellular Component	GO:0005794	Golgi apparatus	FGFR4	IDA		Human	PMID:18061161
Cellular Component	GO:0005886	plasma membrane	FGFR4	IDA		Human	PMID:18061161
Cellular Component	GO:0005886	plasma membrane	FGFR4	IDA		Human	PMID:20683963
Cellular Component	GO:0030133	transport vesicle	FGFR4	IDA		Human	PMID:18061161
Biological Process	GO:0061144	alveolar secondary septum development	Fgfr4	IGI	MGI:MGI:95524	Mouse	PMID:9716527
Biological Process	GO:0016477	cell migration	FGFR4	IMP		Human	PMID:20876804
Biological Process	GO:0042632	cholesterol homeostasis	Fgfr4	IMP		Mouse	MGI:MGI:1858658|PMID:10809780
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IPI	UniProtKB:O95750	Human	PMID:10525310
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IGI	UniProtKB:P05230	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IGI	UniProtKB:P08620	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IGI	UniProtKB:P09038	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IGI	UniProtKB:P10767	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IGI	UniProtKB:P31371	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IGI	UniProtKB:P55075	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGFR4	IDA		Human	PMID:21653700
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgfr4	IGI	UniProtKB:O95750	Mouse	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgfr4	IGI	UniProtKB:P05230	Mouse	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgfr4	IPI	UniProtKB:O54796	Rat	PMID:10766846|RGD:8553993
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Fgfr4	IPI	UniProtKB:P15655	Rat	PMID:10766846|RGD:8553993
Biological Process	GO:0042593	glucose homeostasis	Fgfr4	IMP		Mouse	MGI:MGI:3761543|PMID:17664243
Biological Process	GO:0030324	lung development	Fgfr4	IMP		Mouse	PMID:15576401
Biological Process	GO:0090272	negative regulation of fibroblast growth factor production	Fgfr4	IGI	MGI:MGI:95522	Mouse	PMID:24259513
Biological Process	GO:0010629	negative regulation of gene expression	Fgfr4	IGI	MGI:MGI:95522	Mouse	PMID:24259513
Biological Process	GO:0001759	organ induction	Fgfr4	IMP		Mouse	PMID:15576401
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FGFR4	IDA		Human	PMID:18480409
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	FGFR4	IDA		Human	PMID:20683963
Biological Process	GO:0055062	phosphate ion homeostasis	Fgfr4	IMP		Mouse	MGI:MGI:5285060|PMID:21561999
Biological Process	GO:0043085	positive regulation of catalytic activity	FGFR4	IMP		Human	PMID:20798051
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IGI	UniProtKB:P05230	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IGI	UniProtKB:P08620	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IGI	UniProtKB:P09038	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IGI	UniProtKB:P10767	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IGI	UniProtKB:P31371	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IGI	UniProtKB:P55075	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGFR4	IDA		Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgfr4	IGI	UniProtKB:P05230	Mouse	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	Fgfr4	IGI	UniProtKB:O95750	Mouse	PMID:18187602
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	FGFR4	IMP		Human	PMID:21653700
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FGFR4	IMP		Human	PMID:21653700
Biological Process	GO:0010628	positive regulation of gene expression	FGFR4	IMP		Human	PMID:19085950
Biological Process	GO:2000830	positive regulation of parathyroid hormone secretion	Fgfr4	IGI	MGI:MGI:95522	Mouse	PMID:24259513
Biological Process	GO:0045862	positive regulation of proteolysis	FGFR4	IMP		Human	PMID:20798051
Biological Process	GO:0046777	protein autophosphorylation	FGFR4	IDA		Human	PMID:20798051
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	FGFR4	IMP		Human	PMID:17623664
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	FGFR4	IMP		Human	PMID:20683963
Biological Process	GO:0070857	regulation of bile acid biosynthetic process	Fgfr4	IMP		Mouse	MGI:MGI:1858658|PMID:10809780
Biological Process	GO:0010715	regulation of extracellular matrix disassembly	FGFR4	IMP		Human	PMID:20876804
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	fgfr4	IMP	ZFIN:ZDB-MRPHLNO-170915-5	Zfish	PMID:25428693
Biological Process	GO:0019216	regulation of lipid metabolic process	Fgfr4	IMP		Mouse	MGI:MGI:3761543|PMID:17664243
Biological Process	GO:0010966	regulation of phosphate transport	Fgfr4	IGI	MGI:MGI:95522	Mouse	PMID:24259513
Biological Process	GO:0051174	regulation of phosphorus metabolic process	Fgfr4	IGI	MGI:MGI:95522	Mouse	PMID:24259513
Biological Process	GO:0070640	vitamin D3 metabolic process	Fgfr4	IGI	MGI:MGI:95522	Mouse	PMID:24259513

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern