Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FGF1
  • Mouse genes Fgf1
  • Rat genes Fgf1
  • Zfish genes fgf1a,fgf1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fgf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FGF1	IPI	UniProtKB:P11362	Human	PMID:10830168
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FGF1	IPI	UniProtKB:P22607-1	Human	PMID:12815063
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FGF1	IPI	UniProtKB:P22607-2	Human	PMID:12815063
Molecular Function	GO:0005104	fibroblast growth factor receptor binding	FGF1	IMP		Human	PMID:18441324
Molecular Function	GO:0008083	growth factor activity	FGF1	IDA		Human	PMID:20145243
Molecular Function	GO:0008083	growth factor activity	Fgf1	IDA		Rat	PMID:10890892|RGD:70306
Molecular Function	GO:0008201	heparin binding	FGF1	IMP		Human	PMID:18441324
Molecular Function	GO:0008201	heparin binding	FGF1	IDA		Human	PMID:20145243
Molecular Function	GO:0030544	Hsp70 protein binding	Fgf1	IPI	RGD:1311806	Rat	PMID:10510314|RGD:10402562
Molecular Function	GO:0030544	Hsp70 protein binding	Fgf1	IPI	RGD:1311806	Rat	PMID:15030183|RGD:6784522
Molecular Function	GO:0005178	integrin binding	FGF1	IDA		Human	PMID:18441324
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P21802	Human	PMID:10618369
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P11362	Human	PMID:10830168
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P11362	Human	PMID:14613973
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P22607	Human	PMID:14732692
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P11362	Human	PMID:18441324
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P11362	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P21802	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	FGF1	IPI	UniProtKB:P61758	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Fgf1	IPI	UniProtKB:P15880	Mouse	MGI:MGI:3807762|PMID:16263090
Molecular Function	GO:0044548	S100 protein binding	FGF1	IPI	UniProtKB:Q99584	Human	PMID:11432880
Cellular Component	GO:0005737	cytoplasm	Fgf1	IDA		Rat	PMID:1710230|RGD:2290307
Cellular Component	GO:0005829	cytosol	FGF1	IDA		Human	PMID:12746488
Cellular Component	GO:0031012	extracellular matrix	Fgf1	IDA		Mouse	PMID:15381701
Cellular Component	GO:0005576	extracellular region	FGF1	IDA		Human	PMID:12746488
Cellular Component	GO:0005576	extracellular region	Fgf1	IDA		Mouse	PMID:19233122
Cellular Component	GO:0005615	extracellular space	FGF1	IDA		Human	PMID:18400376
Cellular Component	GO:0005615	extracellular space	Fgf1	IDA		Mouse	PMID:15576401
Cellular Component	GO:0005730	nucleolus	Fgf1	IDA		Rat	PMID:1710230|RGD:2290307
Cellular Component	GO:0005654	nucleoplasm	FGF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Fgf1	IDA		Rat	PMID:1710230|RGD:2290307
Biological Process	GO:0032148	activation of protein kinase B activity	FGF1	IMP		Human	PMID:18441324
Biological Process	GO:0060681	branch elongation involved in ureteric bud branching	FGF1	IDA		Human	PMID:11731227
Biological Process	GO:0034605	cellular response to heat	FGF1	IDA		Human	PMID:12746488
Biological Process	GO:0050673	epithelial cell proliferation	Fgf1	IDA		Mouse	PMID:17187775
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IPI	UniProtKB:P11362	Human	PMID:10830168
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:P16092	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:P21803	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:Q03142	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:Q61851	Human	PMID:18187602
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:P11362	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:P21802	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IGI	UniProtKB:P22607	Human	PMID:8663044
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IMP		Human	PMID:18441324
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	FGF1	IDA		Human	PMID:20145243
Biological Process	GO:0030097	hemopoiesis	fgf1a	IMP	ZFIN:ZDB-MRPHLNO-070508-2,ZFIN:ZDB-MRPHLNO-070508-3	Zfish	PMID:17219402
Biological Process	GO:0030324	lung development	Fgf1	IDA		Mouse	PMID:15576401
Biological Process	GO:0072163	mesonephric epithelium development	FGF1	IDA		Human	PMID:11731227
Biological Process	GO:0001759	organ induction	Fgf1	IDA		Mouse	PMID:15576401
Biological Process	GO:0045766	positive regulation of angiogenesis	FGF1	IDA		Human	PMID:20145243
Biological Process	GO:0051781	positive regulation of cell division	FGF1	IDA		Human	PMID:20145243
Biological Process	GO:0030335	positive regulation of cell migration	FGF1	IMP		Human	PMID:18441324
Biological Process	GO:0030335	positive regulation of cell migration	FGF1	IDA		Human	PMID:20145243
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IGI	UniProtKB:P16092	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IGI	UniProtKB:P21803	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IGI	UniProtKB:Q03142	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IGI	UniProtKB:Q61851	Human	PMID:18187602
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IGI	UniProtKB:P11362	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IGI	UniProtKB:P21802	Human	PMID:8663044
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IMP		Human	PMID:18441324
Biological Process	GO:0008284	positive regulation of cell population proliferation	FGF1	IMP		Human	PMID:23469107
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	FGF1	IDA		Human	PMID:19229075
Biological Process	GO:0010595	positive regulation of endothelial cell migration	FGF1	IMP		Human	PMID:23469107
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Fgf1	IDA		Mouse	PMID:17187775
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	FGF1	IMP		Human	PMID:18441324
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	Fgf1	IDA		Rat	PMID:16756958|RGD:10047366
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	FGF1	IDA		Human	PMID:19229075
Biological Process	GO:0043406	positive regulation of MAP kinase activity	FGF1	IDA		Human	PMID:16756958
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Fgf1	IDA		Mouse	PMID:15800000
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	FGF1	IMP		Human	PMID:23469107
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	FGF1	IDA		Human	PMID:19229075
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Fgf1	IGI	MGI:MGI:97168	Mouse	PMID:8898217
Biological Process	GO:2000544	regulation of endothelial cell chemotaxis to fibroblast growth factor	FGF1	IDA		Human	PMID:16756958
Biological Process	GO:1901509	regulation of endothelial tube morphogenesis	FGF1	IMP		Human	PMID:23469107
Biological Process	GO:0042060	wound healing	FGF1	IDA		Human	PMID:16756958

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern