Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FBXW8
  • Mouse genes Fbxw8
  • Rat genes Fbxw8
  • Zfish genes fbxw8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fbxw8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:P63208	Human	PMID:15070733
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:P01106	Human	PMID:17314511
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:P35568	Human	PMID:18498745
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:O35254	Human	PMID:21572988
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:O75147	Human	PMID:21572988
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:Q92918	Human	PMID:24362026
Molecular Function	GO:0005515	protein binding	FBXW8	IPI	UniProtKB:P63208	Human	PMID:27705803
Molecular Function	GO:0005515	protein binding	Fbxw8	IPI	UniProtKB:P20263	Mouse	MGI:MGI:6148490|PMID:29153991
Molecular Function	GO:0005515	protein binding	Fbxw8	IPI	PR:Q9WTX5	Mouse	PMID:16880526
Molecular Function	GO:0005515	protein binding	Fbxw8	IPI	PR:Q8VE73	Mouse	PMID:16880526
Molecular Function	GO:0005515	protein binding	Fbxw8	IPI	UniProtKB:O35254	Rat	PMID:21572988|RGD:8554449
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	FBXW8	IDA		Human	PMID:24362026
Cellular Component	GO:0031467	Cul7-RING ubiquitin ligase complex	FBXW8	IDA		Human	PMID:18498745
Cellular Component	GO:0031467	Cul7-RING ubiquitin ligase complex	FBXW8	IDA		Human	PMID:21572988
Cellular Component	GO:0031467	Cul7-RING ubiquitin ligase complex	FBXW8	IDA		Human	PMID:24362026
Cellular Component	GO:0031467	Cul7-RING ubiquitin ligase complex	Fbxw8	IDA		Mouse	MGI:MGI:5493210|PMID:21572988
Cellular Component	GO:0005829	cytosol	FBXW8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005794	Golgi apparatus	FBXW8	IDA		Human	PMID:21572988
Cellular Component	GO:0005794	Golgi apparatus	Fbxw8	IDA		Rat	PMID:21572988|RGD:8554449
Cellular Component	GO:0048471	perinuclear region of cytoplasm	FBXW8	IDA		Human	PMID:21572988
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Fbxw8	IDA		Rat	PMID:21572988|RGD:8554449
Cellular Component	GO:0019005	SCF ubiquitin ligase complex	Fbxw8	IPI	PR:Q9WTX5	Mouse	PMID:16880526
Biological Process	GO:0008283	cell population proliferation	FBXW8	IDA		Human	PMID:24362026
Biological Process	GO:0007030	Golgi organization	FBXW8	IGI	UniProtKB:P0DL28	Human	PMID:21572988
Biological Process	GO:0007030	Golgi organization	Fbxw8	IMP		Rat	PMID:21572988|RGD:8554449
Biological Process	GO:0060716	labyrinthine layer blood vessel development	Fbxw8	IMP	MGI:MGI:3665136	Mouse	PMID:16880526
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	FBXW8	IDA		Human	PMID:21572988
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Fbxw8	IMP		Rat	PMID:21572988|RGD:8554449
Biological Process	GO:1901485	positive regulation of transcription factor catabolic process	Fbxw8	IDA		Mouse	MGI:MGI:6148490|PMID:29153991
Biological Process	GO:0016567	protein ubiquitination	FBXW8	IDA		Human	PMID:18498745
Biological Process	GO:0016567	protein ubiquitination	FBXW8	IDA		Human	PMID:24362026
Biological Process	GO:0016567	protein ubiquitination	Fbxw8	IDA		Mouse	MGI:MGI:6148490|PMID:29153991
Biological Process	GO:0060712	spongiotrophoblast layer development	Fbxw8	IMP	MGI:MGI:3665136	Mouse	PMID:16880526

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern