Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes FANCD2
  • Mouse genes Fancd2
  • Rat genes Fancd2
  • Zfish genes fancd2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Fancd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070182	DNA polymerase binding	FANCD2	IPI	UniProtKB:Q7Z5Q5	Human	PMID:19995904
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:O00255	Human	PMID:12874027
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:P51587	Human	PMID:15115758
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:Q9NVI1	Human	PMID:17460694
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:P51587	Human	PMID:18212739
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:O60934	Human	PMID:19609304
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:P49959	Human	PMID:19609304
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:Q16658	Human	PMID:20603015
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:Q9NVI1	Human	PMID:20603015
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:Q9Y2M0	Human	PMID:20603015
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:Q9Y2M0	Human	PMID:20603016
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:Q9Y2M0	Human	PMID:20603073
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:P49716	Human	PMID:20805509
Molecular Function	GO:0005515	protein binding	FANCD2	IPI	UniProtKB:P00533	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Fancd2	IPI	UniProtKB:P27661	Mouse	MGI:MGI:5508607|PMID:17304220
Molecular Function	GO:0005515	protein binding	Fancd2	IPI	PR:Q80WJ1	Mouse	PMID:23451117
Cellular Component	GO:0000793	condensed chromosome	Fancd2	IDA		Mouse	PMID:12913077
Cellular Component	GO:0005829	cytosol	FANCD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:1990391	DNA repair complex	FANCD2	IPI		Human	PMID:32269332
Cellular Component	GO:0016604	nuclear body	FANCD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	FANCD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	FANCD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	FANCD2	IDA		Human	PMID:26323318
Cellular Component	GO:0005634	nucleus	Fancd2	IDA		Mouse	PMID:24001775
Biological Process	GO:0048854	brain morphogenesis	Fancd2	IGI	MGI:MGI:1890081	Mouse	PMID:24483844
Biological Process	GO:0034599	cellular response to oxidative stress	Fancd2	IGI	MGI:MGI:1890081	Mouse	PMID:24483844
Biological Process	GO:0006974	DNA damage response	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:12893777
Biological Process	GO:0007276	gamete generation	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:12893777
Biological Process	GO:0007129	homologous chromosome pairing at meiosis	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:12893777
Biological Process	GO:0043066	negative regulation of apoptotic process	fancd2	IGI	ZFIN:ZDB-GENE-990415-270	Zfish	PMID:14667412
Biological Process	GO:0043066	negative regulation of apoptotic process	fancd2	IMP		Zfish	PMID:14667412
Biological Process	GO:0097150	neuronal stem cell population maintenance	Fancd2	IGI	MGI:MGI:1890081	Mouse	PMID:24483844
Biological Process	GO:2000348	regulation of CD40 signaling pathway	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:24501220
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:24501220
Biological Process	GO:0050727	regulation of inflammatory response	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:24501220
Biological Process	GO:0045589	regulation of regulatory T cell differentiation	Fancd2	IMP	MGI:MGI:2673422	Mouse	PMID:24501220
Biological Process	GO:0010332	response to gamma radiation	FANCD2	IDA		Human	PMID:12874027

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern