Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EYA2
  • Mouse genes Eya2
  • Rat genes Eya2
  • Zfish genes eya2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eya2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140793	histone H2Y142 phosphatase activity	EYA2	IDA		Human	PMID:19351884
Molecular Function	GO:0000287	magnesium ion binding	EYA2	IDA		Human	PMID:19351884
Molecular Function	GO:0005515	protein binding	EYA2	IPI	UniProtKB:Q15475	Human	PMID:19497856
Molecular Function	GO:0005515	protein binding	EYA2	IPI	UniProtKB:Q15475	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	EYA2	IPI	UniProtKB:Q15475	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	Eya2	IPI	UniProtKB:Q91WA6	Mouse	MGI:MGI:5437425|PMID:20956555
Molecular Function	GO:0004725	protein tyrosine phosphatase activity	Eya2	IDA		Mouse	PMID:14628052
Cellular Component	GO:0005737	cytoplasm	Eya2	IDA		Mouse	PMID:11700312
Cellular Component	GO:0005829	cytosol	EYA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Eya2	IDA		Mouse	PMID:11700312
Biological Process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Eya2	IDA		Mouse	PMID:11700312
Biological Process	GO:0048839	inner ear development	eya2	IMP	ZFIN:ZDB-MRPHLNO-150604-1	Zfish	PMID:25568117
Biological Process	GO:0097345	mitochondrial outer membrane permeabilization	Eya2	IDA		Mouse	PMID:11700312
Biological Process	GO:0006470	protein dephosphorylation	Eya2	IDA		Mouse	PMID:14628052
Biological Process	GO:0014706	striated muscle tissue development	Eya2	IGI	MGI:MGI:109344	Mouse	PMID:17098221

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern