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Eya2 Gene Detail
Summary
  • Symbol
    Eya2
  • Name
    EYA transcriptional coactivator and phosphatase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109341
    NCBI Gene: 14049
  • Gene Overview
    MyGene.info: EYA2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:165595032-165771727 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.83 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1094 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109341
protein coding gene Chr2:165595028-165771727 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026897
protein coding gene Chr2:171163315-171346589 (+)
A/J MGP_AJ_G0026863
protein coding gene Chr2:164151539-164331078 (+)
AKR/J MGP_AKRJ_G0026836
protein coding gene Chr2:169050235-169227964 (+)
BALB/cJ MGP_BALBcJ_G0026872
protein coding gene Chr2:164511528-164689919 (+)
C3H/HeJ MGP_C3HHeJ_G0026616
protein coding gene Chr2:169389298-169583466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027320
protein coding gene Chr2:176124596-176323008 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024692
protein coding gene Chr2:157546512-157717484 (+)
CAST/EiJ MGP_CASTEiJ_G0026074
protein coding gene Chr2:169886584-170012245 (+)
CBA/J MGP_CBAJ_G0026593
protein coding gene Chr2:182524035-182751783 (+)
DBA/2J MGP_DBA2J_G0026729
protein coding gene Chr2:163308680-163485723 (+)
FVB/NJ MGP_FVBNJ_G0026697
protein coding gene Chr2:161754096-161946779 (+)
LP/J MGP_LPJ_G0026831
protein coding gene Chr2:171206065-171383767 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026716
protein coding gene Chr2:186054800-186244290 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027376
protein coding gene Chr2:168943128-169122540 (+)
PWK/PhJ MGP_PWKPhJ_G0025809
protein coding gene Chr2:162918356-163095387 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025611
protein coding gene Chr2:167855691-168042004 (+)
WSB/EiJ MGP_WSBEiJ_G0026145
protein coding gene Chr2:169829562-170025672 (+)



Homology
more
  • Human Ortholog
    EYA2, EYA transcriptional coactivator and phosphatase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EYA2, EYA transcriptional coactivator and phosphatase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAB1
  • Links
    NCBI Gene ID: 2139
    neXtProt AC: NX_O00167
    UniProt: O00167

  • Chr Location
    20q13.12; chr20:46894624-47188844 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017897 Ensembl Gene Model | MGI Sequence Detail 176696 C57BL/6J ±  kb
transcript ENSMUST00000063433 Ensembl | MGI Sequence Detail 2460 Not Applicable  
polypeptide ENSMUSP00000066244 Ensembl | MGI Sequence Detail 532 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 58
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38386, MGI:2138916
References
more
  • Summaries
    All 58
    Developmental Gene Expression 26
    Gene Ontology 10
    Phenotypes 2
  • Earliest
    J:38379 Xu PX, et al., Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
  • Latest
    J:243794 Yan N, et al., Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1. Sci Rep. 2016 Sep 28;6:33887

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory