About   Help   FAQ
Eya2 Gene Detail
Summary
  • Symbol
    Eya2
  • Name
    EYA transcriptional coactivator and phosphatase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109341
    NCBI Gene: 14049
  • Gene Overview
    MyGene.info: EYA2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:165436952-165613647 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.83 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1093 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109341
protein coding gene Chr2:165436892-165613647 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026897
protein coding gene Chr2:171163315-171346589 (+)
A/J MGP_AJ_G0026863
protein coding gene Chr2:164151539-164331078 (+)
AKR/J MGP_AKRJ_G0026836
protein coding gene Chr2:169050235-169227964 (+)
BALB/cJ MGP_BALBcJ_G0026872
protein coding gene Chr2:164511528-164689919 (+)
C3H/HeJ MGP_C3HHeJ_G0026616
protein coding gene Chr2:169389298-169583466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027320
protein coding gene Chr2:176124596-176323008 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024692
protein coding gene Chr2:157546512-157717484 (+)
CAST/EiJ MGP_CASTEiJ_G0026074
protein coding gene Chr2:169886584-170012245 (+)
CBA/J MGP_CBAJ_G0026593
protein coding gene Chr2:182524035-182751783 (+)
DBA/2J MGP_DBA2J_G0026729
protein coding gene Chr2:163308680-163485723 (+)
FVB/NJ MGP_FVBNJ_G0026697
protein coding gene Chr2:161754096-161946779 (+)
LP/J MGP_LPJ_G0026831
protein coding gene Chr2:171206065-171383767 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026716
protein coding gene Chr2:186054800-186244290 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027376
protein coding gene Chr2:168943128-169122540 (+)
PWK/PhJ MGP_PWKPhJ_G0025809
protein coding gene Chr2:162918356-163095387 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025611
protein coding gene Chr2:167855691-168042004 (+)
WSB/EiJ MGP_WSBEiJ_G0026145
protein coding gene Chr2:169829562-170025672 (+)



Homology
more
  • Human Ortholog
    EYA2, EYA transcriptional coactivator and phosphatase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EYA2, EYA transcriptional coactivator and phosphatase 2
  • Synonyms
    EAB1
  • Links
    NCBI Gene ID: 2139
    neXtProt AC: NX_O00167
    UniProt: O00167

  • Chr Location
    20q13.12; chr20:46894624-47188844 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017897 Ensembl Gene Model | MGI Sequence Detail 176696 C57BL/6J ±  kb
    transcript ENSMUST00000088132 Ensembl | MGI Sequence Detail 2447 Not Applicable  
    polypeptide ENSMUSP00000085455 Ensembl | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 60
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38386, MGI:2138916
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 30
      Gene Ontology 8
      Phenotypes 4
    • Earliest
      J:38379 Xu PX, et al., Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
    • Latest
      J:299019 Dash S, et al., The Mediator Subunit, Med23 Is Required for Embryonic Survival and Regulation of Canonical WNT Signaling During Cranial Ganglia Development. Front Physiol. 2020;11:531933

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/07/2021
    MGI 6.17
    The Jackson Laboratory