Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ESAM
  • Mouse genes Esam
  • Rat genes Esam
  • Zfish genes esama,esamb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Esam

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098632	cell-cell adhesion mediator activity	ESAM	IDA		Human	PMID:20298433
Molecular Function	GO:0005515	protein binding	ESAM	IPI	UniProtKB:O95832	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	ESAM	IPI	UniProtKB:P16284	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	ESAM	IPI	UniProtKB:Q16625	Human	PMID:26607202
Molecular Function	GO:0005515	protein binding	ESAM	IPI	UniProtKB:P55061	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ESAM	IPI	UniProtKB:Q5BVD1	Human	PMID:32296183
Cellular Component	GO:0005912	adherens junction	Esam	IDA		Mouse	PMID:11279107
Cellular Component	GO:0005923	bicellular tight junction	Esam	IDA		Mouse	PMID:11847224
Cellular Component	GO:0005911	cell-cell junction	ESAM	IDA		Human	PMID:20298433
Cellular Component	GO:0005886	plasma membrane	ESAM	IDA		Human	PMID:20298433
Cellular Component	GO:0005886	plasma membrane	Esam	IDA		Mouse	PMID:11279107
Cellular Component	GO:0032991	protein-containing complex	ESAM	IDA		Human	PMID:26607202
Biological Process	GO:0070830	bicellular tight junction assembly	ESAM	IMP		Human	PMID:26607202
Biological Process	GO:0120078	cell adhesion involved in sprouting angiogenesis	esama	IGI	ZFIN:ZDB-GENO-170620-9	Zfish	PMID:28264837
Biological Process	GO:0098609	cell-cell adhesion	ESAM	IDA		Human	PMID:20298433
Biological Process	GO:0098609	cell-cell adhesion	Esam	IDA		Mouse	PMID:11279107
Biological Process	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	Esam	IDA		Mouse	PMID:11847224
Biological Process	GO:0070527	platelet aggregation	esama	IMP	ZFIN:ZDB-MRPHLNO-090630-7	Zfish	PMID:19109564
Biological Process	GO:0008104	protein localization	ESAM	IDA		Human	PMID:20298433
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	ESAM	IDA		Human	PMID:20298433
Biological Process	GO:0030833	regulation of actin filament polymerization	ESAM	IDA		Human	PMID:20298433

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern