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Esam Gene Detail
Summary
  • Symbol
    Esam
  • Name
    endothelial cell-specific adhesion molecule
  • Synonyms
    2310008D05Rik, W117m
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916774
    NCBI Gene: 69524
  • Gene Overview
    MyGene.info: ESAM
Location & Maps
more
  • Sequence Map
    Chr9:37528078-37538319 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10242 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ESAM, endothelial cell adhesion molecule
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ESAM, endothelial cell adhesion molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    W117m
  • Links
    NCBI Gene ID: 90952
    neXtProt AC: NX_Q96AP7

  • Chr Location
    11q24.2; chr11:124753123-124762327 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12316
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ESAM
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    5
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a null allele exhbit a decrease in body weight, impaired neutrophil transmigration and decreased immune and VEGF-stimulated vascular permeability. Tumor growth is inhibited due to decreased pathological angiogenesis in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033362 VEGA Gene Model | MGI Sequence Detail 10242 C57BL/6J ±  kb
transcript OTTMUST00000083739 VEGA | MGI Sequence Detail 1865 Not Applicable  
polypeptide OTTMUSP00000045032 VEGA | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    120 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007195 endothelial cell-selective adhesion molecule
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003599 Immunoglobulin subtype
    IPR003598 Immunoglobulin subtype 2
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
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  • All nucleic 56
    cDNA 55
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:64925 Chretien I, et al., CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. Eur J Immunol. 1998 Dec;28(12):4094-104
  • Latest
    J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory