About   Help   FAQ
Esam
Gene Detail
 Symbol
Name
ID
Esam
endothelial cell-specific adhesion molecule
MGI:1916774
Synonyms 2310008D05Rik, W117m
Feature Type protein coding gene
Genetic Map
Chromosome 9
20.77 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:37528078-37538319 bp, + strand
From VEGA annotation of GRCm38

  10242 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12316  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Esam

Human
homologs
Human Homolog ESAM, endothelial cell adhesion molecule
NCBI Gene ID 90952
neXtProt AC  NX_Q96AP7
Human Synonyms  W117m
Human Chr (Location)  11q24.2; chr11:124753123-124762327 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhbit a decrease in body weight, impaired neutrophil transmigration and decreased immune and VEGF-stimulated vascular permeability. Tumor growth is inhibited due to decreased pathological angiogenesis in homozygous mutant mice.
 
Interactions
Esam interacts with 108 markers (Mir7-1, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process calcium-independent cell-cell adhesion, cell adhesion, ...
Component adherens junction, cell junction, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (77)    Tissues (38)    Images (35)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 17, 19, 21, 23, 28
Assay TypeResults
RNA in situ 57
Northern blot 7
RT-PCR 13
cDNA source data(55)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) cDNA(55) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033362 (Evidence)
Ensembl Gene ModelENSMUSG00000001946 (Evidence)
Entrez Gene69524 (Evidence)
UniGene41751
DFCITC1583988, TC1630104, TC1699824
DoTSDT.50315435
NIA Mouse Gene IndexU010260
Consensus CDS ProjectCCDS22979.1
International Mouse Knockout Project StatusEsam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033362 VEGA Gene Model | MGI Sequence Detail 10242 C57BL/6J ±  kb
transcript OTTMUST00000083739 VEGA | MGI Sequence Detail 1865 Not Applicable 
polypeptide OTTMUSP00000045032 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(9) UniProt(6)
Polymorphisms SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000007195 endothelial cell-selective adhesion molecule
References (Earliest) J:64925 Chretien I, et al., CTX, a Xenopus thymocyte receptor, defines a molecular family conserved throughout vertebrates. Eur J Immunol. 1998 Dec;28(12):4094-104
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory