Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPN2
  • Mouse genes Epn2
  • Rat genes Epn2
  • Zfish genes epn2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EPN2	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	EPN2	IPI	UniProtKB:Q9UHD9	Human	PMID:18199683
Cellular Component	GO:0030128	clathrin coat of endocytic vesicle	Epn2	IDA		Rat	PMID:10567358|RGD:708327
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	EPN2	IDA		Human	GO_REF:0000052
Biological Process	GO:0048568	embryonic organ development	Epn2	IGI	MGI:MGI:1333763	Mouse	PMID:19666558
Biological Process	GO:0001701	in utero embryonic development	Epn2	IGI	MGI:MGI:1333763	Mouse	PMID:19666558
Biological Process	GO:1903671	negative regulation of sprouting angiogenesis	EPN2	IMP		Human	PMID:28717225
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	EPN2	IMP		Human	PMID:28717225
Biological Process	GO:0007219	Notch signaling pathway	Epn2	IGI	MGI:MGI:1333763	Mouse	PMID:19666558
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	EPN2	IMP		Human	PMID:28717225
Biological Process	GO:0030100	regulation of endocytosis	Epn2	IDA		Rat	PMID:10567358|RGD:708327

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern