Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2B4
  • Mouse genes Eif2b4
  • Rat genes Eif2b4
  • Zfish genes eif2b4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2b4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EIF2B4	IDA		Human	PMID:11323413
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EIF2B4	IMP		Human	PMID:15054402
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Eif2b4	IDA		Rat	PMID:9582312|RGD:1581075
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Eif2b4	IDA		Rat	PMID:9631509|RGD:11041878
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Eif2b4	IDA		Rat	PMID:9139680|RGD:1581073
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P49770	Human	PMID:15060152
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:Q13144	Human	PMID:15060152
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:Q53XC2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P49770	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:C5E519	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P06821	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:Q20MH8	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:Q6DPW5	Human	PMID:28169297
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P49770	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P49770	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P01019	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P01100	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P03952	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P06858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P31930	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P40337-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P50440	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EIF2B4	IPI	UniProtKB:P62993	Human	PMID:32814053
Molecular Function	GO:0003743	translation initiation factor activity	EIF2B4	IDA		Human	PMID:16289705
Molecular Function	GO:0031369	translation initiation factor binding	Eif2b4	IDA		Rat	PMID:9446619|RGD:1581068
Cellular Component	GO:0005737	cytoplasm	EIF2B4	IDA		Human	PMID:11323413
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B4	IDA		Human	PMID:11323413
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2B4	IDA		Human	PMID:15060152
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	Eif2b4	IDA		Rat	PMID:9139680|RGD:1581073
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	Eif2b4	IDA		Rat	PMID:9582312|RGD:1581075
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	Eif2b4	IDA		Rat	PMID:9631509|RGD:11041878
Biological Process	GO:0021766	hippocampus development	Eif2b4	IEP		Rat	PMID:12850562|RGD:11041879
Biological Process	GO:0042552	myelination	EIF2B4	IMP		Human	PMID:14566705
Biological Process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	Eif2b4	IDA		Rat	PMID:9582312|RGD:1581075
Biological Process	GO:0014003	oligodendrocyte development	EIF2B4	IMP		Human	PMID:15217090
Biological Process	GO:0001541	ovarian follicle development	EIF2B4	IMP		Human	PMID:15507143
Biological Process	GO:0009749	response to glucose	Eif2b4	IDA		Rat	PMID:8567668|RGD:8554699
Biological Process	GO:0009408	response to heat	Eif2b4	IDA		Rat	PMID:9341116|RGD:8554311
Biological Process	GO:0043434	response to peptide hormone	Eif2b4	IDA		Rat	PMID:8430778|RGD:8553606
Biological Process	GO:0050852	T cell receptor signaling pathway	EIF2B4	IDA		Human	PMID:8626696
Biological Process	GO:0006413	translational initiation	EIF2B4	IDA		Human	PMID:16289705

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern