Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2A
  • Mouse genes Eif2a
  • Rat genes Eif2a
  • Zfish genes eif2a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EIF2A	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	EIF2A	IPI	UniProtKB:Q14899	Human	PMID:18816594
Molecular Function	GO:0043022	ribosome binding	EIF2A	IMP		Human	PMID:12133843
Molecular Function	GO:0003743	translation initiation factor activity	EIF2A	IDA		Human	PMID:10563826
Molecular Function	GO:0003743	translation initiation factor activity	EIF2A	IMP		Human	PMID:12133843
Molecular Function	GO:0000049	tRNA binding	EIF2A	IMP		Human	PMID:12133843
Cellular Component	GO:0072562	blood microparticle	EIF2A	HDA		Human	PMID:22516433
Cellular Component	GO:0005737	cytoplasm	EIF2A	IDA		Human	PMID:12133843
Cellular Component	GO:0005737	cytoplasm	Eif2a	IDA		Rat	PMID:16912310|RGD:32733622
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	EIF2A	IDA		Human	PMID:12133843
Cellular Component	GO:0005615	extracellular space	EIF2A	HDA		Human	PMID:22664934
Biological Process	GO:0009967	positive regulation of signal transduction	Eif2a	IDA		Mouse	PMID:18852460
Biological Process	GO:0006468	protein phosphorylation	Eif2a	IDA		Mouse	PMID:16705175
Biological Process	GO:0006417	regulation of translation	EIF2A	IMP		Human	PMID:12133843
Biological Process	GO:1990928	response to amino acid starvation	Eif2a	IDA		Rat	PMID:11500297|RGD:1581065
Biological Process	GO:0042255	ribosome assembly	EIF2A	IMP		Human	PMID:12133843
Biological Process	GO:0032933	SREBP signaling pathway	Eif2a	IDA		Mouse	PMID:18852460
Biological Process	GO:0006412	translation	Eif2a	IDA		Mouse	PMID:7519779
Biological Process	GO:0006413	translational initiation	EIF2A	IDA		Human	PMID:12133843

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern