Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EAF2
  • Mouse genes Eaf2
  • Rat genes Eaf2
  • Zfish genes eaf2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eaf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0070016	armadillo repeat domain binding	eaf2	IDA		Zfish	PMID:23364330
Molecular Function	GO:0008013	beta-catenin binding	eaf2	IPI	ZFIN:ZDB-GENE-040426-2575	Zfish	PMID:23364330
Molecular Function	GO:0008013	beta-catenin binding	eaf2	IPI	ZFIN:ZDB-GENE-980526-362	Zfish	PMID:23364330
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:P0C1Z6	Human	PMID:17395368
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:P61289	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:Q16665	Human	PMID:24421387
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:P36406	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:Q13490	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:Q8N7W2-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:P61289	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:Q8N7W2-2	Human	PMID:27107012
Molecular Function	GO:0005515	protein binding	EAF2	IPI	UniProtKB:Q15560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Eaf2	IPI	PR:O88522	Mouse	PMID:12761297
Molecular Function	GO:0005515	protein binding	eaf2	IPI	ZFIN:ZDB-GENE-990603-8	Zfish	PMID:28887217
Molecular Function	GO:0005515	protein binding	eaf2	IPI	ZFIN:ZDB-GENE-000616-15	Zfish	PMID:28887217
Molecular Function	GO:0005515	protein binding	eaf2	IPI	ZFIN:ZDB-GENE-990603-7	Zfish	PMID:28887217
Molecular Function	GO:0005515	protein binding	eaf2	IPI	ZFIN:ZDB-GENE-000509-3	Zfish	PMID:28887217
Molecular Function	GO:0005515	protein binding	eaf2	IPI	ZFIN:ZDB-GENE-990415-270	Zfish	PMID:28887217
Molecular Function	GO:0005515	protein binding	eaf2	IPI	ZFIN:ZDB-GENE-030131-7859	Zfish	PMID:23364330
Molecular Function	GO:0003714	transcription corepressor activity	eaf2	IPI	ZFIN:ZDB-GENE-990415-270	Zfish	PMID:28887217
Molecular Function	GO:0003714	transcription corepressor activity	eaf2	IDA		Zfish	PMID:28887217
Molecular Function	GO:0003714	transcription corepressor activity	eaf2	IMP		Zfish	PMID:28887217
Molecular Function	GO:0003711	transcription elongation factor activity	EAF2	IMP		Human	PMID:32087315
Cellular Component	GO:0005654	nucleoplasm	Eaf2	IDA		Mouse	PMID:12761297
Cellular Component	GO:0008023	transcription elongation factor complex	EAF2	IDA		Human	PMID:22195968
Biological Process	GO:0016049	cell growth	Eaf2	IMP	MGI:MGI:3834174	Mouse	PMID:17873910
Biological Process	GO:0042074	cell migration involved in gastrulation	eaf2	IGI	ZFIN:ZDB-MRPHLNO-090820-4,ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0060028	convergent extension involved in axis elongation	eaf2	IMP	ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0060029	convergent extension involved in organogenesis	eaf2	IGI	ZFIN:ZDB-MRPHLNO-090820-4,ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	Eaf2	IMP	MGI:MGI:3834174	Mouse	PMID:17873910
Biological Process	GO:0007507	heart development	eaf2	IGI	ZFIN:ZDB-MRPHLNO-090820-4,ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0014812	muscle cell migration	eaf2	IGI	ZFIN:ZDB-MRPHLNO-090820-4,ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0030308	negative regulation of cell growth	Eaf2	IMP	MGI:MGI:3834174	Mouse	PMID:17873910
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	Eaf2	IMP	MGI:MGI:3834174	Mouse	PMID:17873910
Biological Process	GO:0031016	pancreas development	eaf2	IGI	ZFIN:ZDB-MRPHLNO-090820-4,ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Eaf2	IDA		Mouse	PMID:12761297
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EAF2	IDA		Human	PMID:16114057
Biological Process	GO:0034243	regulation of transcription elongation by RNA polymerase II	EAF2	IMP		Human	PMID:32087315
Biological Process	GO:0030111	regulation of Wnt signaling pathway	eaf2	IGI	ZFIN:ZDB-MRPHLNO-090820-4,ZFIN:ZDB-MRPHLNO-090820-6	Zfish	PMID:19380582
Biological Process	GO:0060799	transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification	eaf2	IMP		Zfish	PMID:28887217
Biological Process	GO:0060798	transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification	eaf2	IMP		Zfish	PMID:28887217

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern