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Eaf2 Gene Detail
Summary
  • Symbol
    Eaf2
  • Name
    ELL associated factor 2
  • Synonyms
    Festa, FESTA-L, FESTA-S, Traits, U19
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146616
    NCBI Gene: 106389
  • Gene Overview
    MyGene.info: EAF2
Location & Maps
more
  • Sequence Map
    Chr16:36792884-36875003 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      82120 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.05 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    EAF2, ELL associated factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EAF2, ELL associated factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BM040, TRAITS, U19
  • Links
    NCBI Gene ID: 55840
    neXtProt AC: NX_Q96CJ1

  • Chr Location
    3q13.33; chr3:121835187-121886526 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10208
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EAF2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    3
  • Targeted
    2
  • Incidental Mutations
Mice homozygous for a null allele exhibit premature death, enlarged heart and prostate associate with hypertrophy, and increased incidence of tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024641 VEGA Gene Model | MGI Sequence Detail 82120 C57BL/6J ±  kb
transcript OTTMUST00000060572 VEGA | MGI Sequence Detail 1030 Not Applicable  
polypeptide OTTMUSP00000029552 VEGA | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    156 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006862 ELL-associated factor 2
  • InterPro Domains
    IPR027093 EAF family
    IPR019194 Transcription elognation factor Eaf, N-terminal
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:85253 Saso K, et al., Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. J Biochem. 2003 Apr;133(4):493-500
  • Latest
    J:212591 Ai J, et al., Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model. Oncogene. 2014 May 1;33(18):2286-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory