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Eaf2
Gene Detail
 Symbol
Name
ID
Eaf2
ELL associated factor 2
MGI:2146616
Synonyms Festa, FESTA-L, FESTA-S, Traits, U19
Feature Type protein coding gene
Genetic Map
Chromosome 16
26.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:36792884-36875003 bp, - strand
From VEGA annotation of GRCm38

  82120 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eaf2

Human
homologs
Human Homolog EAF2, ELL associated factor 2
NCBI Gene ID 55840
neXtProt AC  NX_Q96CJ1
Human Synonyms  BM040, TRAITS, U19
Human Chr (Location)  3q13.33; chr3:121835183-121886526 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit premature death, enlarged heart and prostate associate with hypertrophy, and increased incidence of tumors.
 
Interactions
Eaf2 interacts with 122 markers (Mir1b, Mir7-1, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process intrinsic apoptotic signaling pathway, negative regulation of cell growth, ...
Component ELL-EAF complex, nucleoplasm, ...
Function protein binding, RNA polymerase II regulatory region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (163)    Tissues (156)    Images (21)
Theiler Stages: 16, 18, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 150
Northern blot 13
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024641 (Evidence)
Ensembl Gene ModelENSMUSG00000022838 (Evidence)
Entrez Gene106389 (Evidence)
UniGene432078
NIA Mouse Gene IndexU037023
Consensus CDS ProjectCCDS37335.1, CCDS49843.1
International Mouse Knockout Project StatusEaf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024641 VEGA Gene Model | MGI Sequence Detail 82120 C57BL/6J ±  kb
transcript OTTMUST00000060572 VEGA | MGI Sequence Detail 1030 Not Applicable 
polypeptide OTTMUSP00000029552 VEGA | MGI Sequence Detail 262 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(16) UniProt(2)
Polymorphisms SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027093 EAF family
InterPro IPR019194 Transcription elognation factor Eaf, N-terminal
Protein Ontology PR:000006862 ELL-associated factor 2
References (Earliest) J:85253 Saso K, et al., Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. J Biochem. 2003 Apr;133(4):493-500
(Latest) J:209680 Pascal LE, et al., Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice. PLoS One. 2013;8(11):e79542
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory