Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DSC2
  • Mouse genes Dsc2
  • Rat genes Dsc2
  • Zfish genes dsc2l
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dsc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	DSC2	IPI	UniProtKB:F1M7L9	Human	PMID:21062920
Molecular Function	GO:0005515	protein binding	DSC2	IPI	UniProtKB:P15924	Human	PMID:21062920
Molecular Function	GO:0005515	protein binding	DSC2	IPI	UniProtKB:Q6P0K8	Human	PMID:21062920
Cellular Component	GO:0005912	adherens junction	Dsc2	IDA		Mouse	PMID:15775979
Cellular Component	GO:0031410	cytoplasmic vesicle	DSC2	IDA		Human	PMID:21062920
Cellular Component	GO:0030057	desmosome	DSC2	IDA		Human	PMID:21062920
Cellular Component	GO:0030057	desmosome	DSC2	IDA		Human	PMID:21220045
Cellular Component	GO:0030057	desmosome	Dsc2	IDA		Mouse	PMID:15775979
Cellular Component	GO:0030057	desmosome	Dsc2	IDA		Mouse	PMID:9864371
Cellular Component	GO:0005783	endoplasmic reticulum	DSC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	DSC2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	DSC2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	DSC2	HDA		Human	PMID:23533145
Cellular Component	GO:0014704	intercalated disc	DSC2	IDA		Human	PMID:21062920
Cellular Component	GO:0014704	intercalated disc	DSC2	IDA		Human	PMID:21220045
Cellular Component	GO:0014704	intercalated disc	DSC2	IDA		Human	PMID:23863954
Cellular Component	GO:0005886	plasma membrane	DSC2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	DSC2	IDA		Human	PMID:23863954
Biological Process	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication	DSC2	IMP		Human	PMID:23863954
Biological Process	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion	DSC2	IMP		Human	PMID:21062920
Biological Process	GO:0009267	cellular response to starvation	Dsc2	IEP		Mouse	PMID:23260145
Biological Process	GO:0060027	convergent extension involved in gastrulation	dsc2l	IMP	ZFIN:ZDB-MRPHLNO-120227-3	Zfish	PMID:22235774
Biological Process	GO:0002159	desmosome assembly	dsc2l	IMP	ZFIN:ZDB-MRPHLNO-120227-3	Zfish	PMID:22235774
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	dsc2l	IMP	ZFIN:ZDB-MRPHLNO-120227-3	Zfish	PMID:22235774
Biological Process	GO:0060047	heart contraction	dsc2l	IMP	ZFIN:ZDB-MRPHLNO-211213-2	Zfish	PMID:33784018
Biological Process	GO:0060047	heart contraction	dsc2l	IMP	ZFIN:ZDB-MRPHLNO-211213-1	Zfish	PMID:33784018
Biological Process	GO:0007507	heart development	dsc2l	IMP	ZFIN:ZDB-MRPHLNO-070206-2	Zfish	PMID:17186466
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	DSC2	IMP		Human	PMID:23863954
Biological Process	GO:0098911	regulation of ventricular cardiac muscle cell action potential	DSC2	IMP		Human	PMID:23863954

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern