About   Help   FAQ
Gene Ontology Browser
Term Detail
GO term:desmosome
Synonym: macula adherens
Synonym: spot desmosome
GO id:GO:0030057
Definition:A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell junction
                        is-aanchoring junction
                                is-aadherens junction +
                                is-adesmosome [GO:0030057] (21 genes, 27 annotations)


Gene_Ontology
        is-acellular_component
                is-acell junction
                        is-acell-cell junction
                                is-aapical junction complex +
                                is-acell-cell adherens junction +
                                is-acell-cell contact zone +
                                is-adesmosome [GO:0030057] (21 genes, 27 annotations)
                                is-afiltration diaphragm +
                                is-agap junction +
                                is-aintercellular canaliculus
                                is-aoccluding junction +
                                is-aparanodal junction
                                is-aplasmodesma +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory