Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DOCK8
  • Mouse genes Dock8
  • Rat genes Dock8
  • Zfish genes dock8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dock8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	DOCK8	IDA		Human	PMID:28028151
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Dock8	IDA		Mouse	PMID:22461490
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q99836	Human	PMID:22581261
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q5VUJ6	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q9Y2L9	Human	PMID:24255178
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q6A162	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q9Y2V2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q9BSJ6	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:P60953	Human	PMID:28028151
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q9Y2L9	Human	PMID:28028151
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q5VUJ6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q9Y2L9	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	DOCK8	IPI	UniProtKB:Q5VUJ6	Human	PMID:32203420
Molecular Function	GO:0005515	protein binding	Dock8	IPI	UniProtKB:P62046	Mouse	MGI:MGI:5824146|PMID:28028151
Cellular Component	GO:0031252	cell leading edge	Dock8	IDA		Mouse	PMID:22461490
Cellular Component	GO:0005737	cytoplasm	DOCK8	IDA		Human	PMID:28028151
Cellular Component	GO:0005829	cytosol	DOCK8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0031256	leading edge membrane	DOCK8	IDA		Human	PMID:28028151
Cellular Component	GO:0016020	membrane	DOCK8	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	DOCK8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	DOCK8	IDA		Human	GO_REF:0000052
Biological Process	GO:1990869	cellular response to chemokine	DOCK8	IMP		Human	PMID:28028151
Biological Process	GO:0036336	dendritic cell migration	Dock8	IMP		Mouse	MGI:MGI:5634023|PMID:25713392
Biological Process	GO:0036336	dendritic cell migration	Dock8	IGI	MGI:MGI:106211	Mouse	PMID:22461490
Biological Process	GO:0036336	dendritic cell migration	Dock8	IMP	MGI:MGI:5437274	Mouse	PMID:22461490
Biological Process	GO:0001771	immunological synapse formation	Dock8	IMP	MGI:MGI:3835421	Mouse	PMID:22006977
Biological Process	GO:0061485	memory T cell proliferation	DOCK8	IMP		Human	PMID:22006977
Biological Process	GO:1904124	microglial cell migration	dock8	IMP	ZFIN:ZDB-GENO-230222-6	Zfish	PMID:35977943
Biological Process	GO:1904124	microglial cell migration	dock8	IMP	ZFIN:ZDB-GENO-230222-5	Zfish	PMID:35977943
Biological Process	GO:1904124	microglial cell migration	dock8	IMP	ZFIN:ZDB-GENO-230222-9	Zfish	PMID:35977943
Biological Process	GO:1904124	microglial cell migration	dock8	IMP	ZFIN:ZDB-GENO-230222-2	Zfish	PMID:35977943
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	Dock8	IMP	MGI:MGI:3835422	Mouse	PMID:21969276
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	DOCK8	IMP		Human	PMID:28028151
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	Dock8	IMP		Mouse	MGI:MGI:5824146|PMID:28028151
Biological Process	GO:0043547	positive regulation of GTPase activity	DOCK8	IDA		Human	PMID:28028151
Biological Process	GO:2000406	positive regulation of T cell migration	DOCK8	IMP		Human	PMID:28028151
Biological Process	GO:2000406	positive regulation of T cell migration	Dock8	IMP		Mouse	MGI:MGI:5824146|PMID:28028151

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern