Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DOCK4
  • Mouse genes Dock4
  • Rat genes Dock4
  • Zfish genes dock4,dock4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dock4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	DOCK4	IDA		Human	PMID:16464467
Molecular Function	GO:0030165	PDZ domain binding	DOCK4	IPI	UniProtKB:Q9Y6N9	Human	PMID:16464467
Molecular Function	GO:0005515	protein binding	DOCK4	IPI	UniProtKB:Q9Y6N9	Human	PMID:16464467
Molecular Function	GO:0005515	protein binding	DOCK4	IPI	UniProtKB:Q96JJ3	Human	PMID:20679435
Molecular Function	GO:0005515	protein binding	DOCK4	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	DOCK4	IPI	UniProtKB:P62993	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	DOCK4	IPI	UniProtKB:P62993	Human	PMID:31980649
Molecular Function	GO:0030971	receptor tyrosine kinase binding	DOCK4	IPI	UniProtKB:P29317	Human	PMID:20679435
Molecular Function	GO:0031267	small GTPase binding	DOCK4	IDA		Human	PMID:16464467
Cellular Component	GO:0005829	cytosol	DOCK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	DOCK4	IDA		Human	PMID:20679435
Cellular Component	GO:0005794	Golgi apparatus	DOCK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	DOCK4	IDA		Human	PMID:20679435
Cellular Component	GO:0005730	nucleolus	DOCK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	DOCK4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032420	stereocilium	Dock4	IDA		Mouse	MGI:MGI:3640027|PMID:16464467
Cellular Component	GO:0032421	stereocilium bundle	Dock4	IDA		Mouse	MGI:MGI:3640027|PMID:16464467
Biological Process	GO:0060326	cell chemotaxis	DOCK4	IMP		Human	PMID:20679435
Biological Process	GO:1904694	negative regulation of vascular associated smooth muscle contraction	DOCK4	IMP		Human	PMID:22158624
Biological Process	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	DOCK4	IMP		Human	PMID:22158624

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern