Dock4 MGI Mouse Gene Detail - MGI:1918006 - dedicator of cytokinesis 4

Dock4 Gene Detail

Symbol

Dock4
Name

dedicator of cytokinesis 4
Synonyms

6330411N01Rik, EST N28122, mKIAA0716

Feature Type

protein coding gene
IDs

MGI:1918006
NCBI Gene: 238130
Gene Overview

MyGene.info: DOCK4

Sequence Map

Chr12:40446053-40846486 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

400434 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 18.06 cM
Mapping Data

3 experiments

Human Ortholog

DOCK4, dedicator of cytokinesis 4

Vertebrate Orthologs

9

Human Ortholog

DOCK4, dedicator of cytokinesis 4
Orthology source: HomoloGene, HGNC
Links

HGNC:19192

NCBI Gene ID: 9732

neXtProt AC: NX_Q8N1I0

UniProt: Q8N1I0
Chr Location

7q31.1; chr7:111726108-112206407 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56680
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DOCK4
Gene Tree

Dock4

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
1 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

6
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation.

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All GO Annotations

19
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

2
Tissues

1
cDNA Data

35
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock4

ZFIN dock4b

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Dock4 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

39
RefSeq

16
UniProt

5
CCDS

CCDS25895.1
UniGene

341423

Ensembl

ENSMUSG00000035954 (Evidence)
NCBI Gene

238130

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035954	Ensembl Gene Model \| MGI Sequence Detail	400434	C57BL/6J	± kb
transcript	ENSMUST00000037488	Ensembl \| MGI Sequence Detail	8063	Not Applicable
polypeptide	ENSMUSP00000047387	Ensembl \| MGI Sequence Detail	1978	Not Applicable

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SNPs within 2kb

3418 from dbSNP Build 142

PCR

1

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UniProt

5 Sequences
Protein Ontology

PR:000006621 dedicator of cytokinesis protein 4

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR026791 Dedicator of cytokinesis

IPR026800 Dedicator of cytokinesis 3/4

IPR010703 Dedicator of cytokinesis, C-terminal

IPR032376 Dedicator of cytokinesis, N-terminal domain

IPR027007 DHR-1 domain

IPR027357 DHR-2 domain

IPR001452 SH3 domain

IPR011511 Variant SH3 domain

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All nucleic 44

cDNA 43

Primer pair 1

Microarray probesets 2

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MGI:1858606

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 7
Earliest

J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
Latest

J:224385 Abraham S, et al., A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nat Commun. 2015;6:7286

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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