Dock4 MGI Mouse Gene Detail - MGI:1918006 - dedicator of cytokinesis 4

Symbol

Dock4
Name

dedicator of cytokinesis 4
Synonyms

6330411N01Rik, EST N28122, mKIAA0716

Feature Type

protein coding gene
IDs

MGI:1918006
NCBI Gene: 238130
Gene Overview

MyGene.info: DOCK4
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:40445957-40846874 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 18.06 cM
Mapping Data

3 experiments

SNPs within 2kb

3420 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918006	protein coding gene	Chr12:40445952-40846874 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019705	protein coding gene	Chr12:38863099-39280689 (+)
A/J	MGP_AJ_G0019671	protein coding gene	Chr12:37587615-37994829 (+)
AKR/J	MGP_AKRJ_G0019642	protein coding gene	Chr12:38729932-39136356 (+)
BALB/cJ	MGP_BALBcJ_G0019649	protein coding gene	Chr12:37800211-38203840 (+)
C3H/HeJ	MGP_C3HHeJ_G0019453	protein coding gene	Chr12:38657588-39077611 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020096	protein coding gene	Chr12:40021859-40440724 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017721	protein coding gene	Chr12:36707188-37112752 (+)
CAST/EiJ	MGP_CASTEiJ_G0019006	protein coding gene	Chr12:33834831-34275452 (+)
CBA/J	MGP_CBAJ_G0019425	protein coding gene	Chr12:41384851-41815284 (+)
DBA/2J	MGP_DBA2J_G0019538	protein coding gene	Chr12:37438238-37840317 (+)
FVB/NJ	MGP_FVBNJ_G0019527	protein coding gene	Chr12:37067772-37470025 (+)
LP/J	MGP_LPJ_G0019608	protein coding gene	Chr12:38860225-39281084 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019563	protein coding gene	Chr12:41531570-41969638 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020136	protein coding gene	Chr12:38289186-38706299 (+)
PWK/PhJ	MGP_PWKPhJ_G0018773	protein coding gene	Chr12:32113309-32523133 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018563	protein coding gene	Chr12:33126539-33365683 (+)
WSB/EiJ	MGP_WSBEiJ_G0019056	protein coding gene	Chr12:38592250-39008377 (+)

Human Ortholog

DOCK4, dedicator of cytokinesis 4

Vertebrate Orthologs

9

Human Ortholog

DOCK4, dedicator of cytokinesis 4
Orthology source: HomoloGene, HGNC
Links

HGNC:19192

NCBI Gene ID: 9732

neXtProt AC: NX_Q8N1I0

UniProt: Q8N1I0
Chr Location

7q31.1; chr7:111726108-112206407 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56680
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DOCK4
Gene Tree

Dock4

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
1 images
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Gene trapped

6
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

3 strains or lines available

Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation.

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All GO Annotations

18
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

633
Tissues

1
cDNA Data

37
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dock4

ZFIN dock4b

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Dock4 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

74
RefSeq

24
UniProt

5
CCDS

CCDS25895.1
UniGene

341423

Ensembl

ENSMUSG00000035954 (Evidence)
NCBI Gene

238130

			Length	Strain/Species	Flank
genomic	238130	NCBI Gene Model \| MGI Sequence Detail	400918	C57BL/6J	± kb
transcript	NM_172803	RefSeq \| MGI Sequence Detail	8072	Not Specified
polypeptide	P59764	UniProt \| EBI \| MGI Sequence Detail	1978	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006621 dedicator of cytokinesis protein 4

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR035892 C2 domain superfamily

IPR026791 Dedicator of cytokinesis

IPR037014 Dedicator of cytokinesis 4

IPR035769 Dedicator of cytokinesis 4, SH3 domain

IPR037811 Dedicator of cytokinesis B, C2 domain

IPR010703 Dedicator of cytokinesis, C-terminal

IPR043161 Dedicator of cytokinesis, C-terminal, lobe A

IPR043162 Dedicator of cytokinesis, C-terminal, lobe C

IPR032376 Dedicator of cytokinesis, N-terminal domain

IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1

IPR027007 DHR-1 domain

IPR027357 DHR-2 domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 46

cDNA 45

Primer pair 1

Microarray probesets 2

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MGI:1858606

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 8
Earliest

J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
Latest

J:282954 Huang L, et al., SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature. 2019 May;569(7757):565-569

TSS for Dock4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113310	Chr12:40445993-40446015 (+)	47 bp
Tssr113311	Chr12:40446050-40446099 (+)	118 bp
Tssr3829	Chr12:40446119-40446128 (+)	167 bp
Tssr113312	Chr12:40446148-40446159 (+)	197 bp
Tssr113341	Chr12:40794259-40794271 (+)	348,308 bp
Tssr113342	Chr12:40794284-40794298 (+)	348,334 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16