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Dock4 Gene Detail
Summary
  • Symbol
    Dock4
  • Name
    dedicator of cytokinesis 4
  • Synonyms
    6330411N01Rik, EST N28122, mKIAA0716
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918006
    NCBI Gene: 238130
  • Gene Overview
    MyGene.info: DOCK4
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr12:40445957-40846874 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      400918 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 18.06 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DOCK4, dedicator of cytokinesis 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DOCK4, dedicator of cytokinesis 4
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9732
    neXtProt AC: NX_Q8N1I0
    UniProt: Q8N1I0

  • Chr Location
    7q31.1; chr7:111726108-112206407 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 56680
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DOCK4
  • Gene Tree
    Dock4
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2
  • Tissues
    1
  • cDNA Data
    35
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 238130 NCBI Gene Model | MGI Sequence Detail 400918 C57BL/6J ±  kb
transcript NM_172803 RefSeq | MGI Sequence Detail 8072 Not Specified  
polypeptide P59764 UniProt | EBI | MGI Sequence Detail 1978 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3420 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1858606
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
  • Latest
    J:224385 Abraham S, et al., A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nat Commun. 2015;6:7286
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/10/2017
MGI 6.10 		The Jackson Laboratory