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Dock4 Gene Detail
Summary
  • Symbol
    Dock4
  • Name
    dedicator of cytokinesis 4
  • Synonyms
    6330411N01Rik, EST N28122, mKIAA0716
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918006
    NCBI Gene: 238130
  • Gene Overview
    MyGene.info: DOCK4
Location & Maps
more
  • Sequence Map
    Chr12:40446053-40846486 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      400434 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DOCK4, dedicator of cytokinesis 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DOCK4, dedicator of cytokinesis 4
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 9732
    neXtProt AC: NX_Q8N1I0

  • Chr Location
    7q31.1; chr7:111726108-112206407 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56680
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DOCK4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035954 Ensembl Gene Model | MGI Sequence Detail 400434 C57BL/6J ±  kb
transcript ENSMUST00000037488 Ensembl | MGI Sequence Detail 8063 Not Applicable  
polypeptide ENSMUSP00000047387 Ensembl | MGI Sequence Detail 1978 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3418 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 43
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1858606
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
  • Latest
    J:224385 Abraham S, et al., A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Nat Commun. 2015;6:7286

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory