Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DOCK10
  • Mouse genes Dock10
  • Rat genes
  • Zfish genes dock10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dock10

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Dock10	IDA		Mouse	MGI:MGI:5825418|PMID:25851601
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Dock10	IDA		Mouse	PMID:15710388
Molecular Function	GO:0005515	protein binding	DOCK10	IPI	UniProtKB:P43364	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK10	IPI	UniProtKB:Q68D86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DOCK10	IPI	UniProtKB:O75400-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	DOCK10	IPI	UniProtKB:Q9Y371	Human	PMID:32814053
Molecular Function	GO:0031267	small GTPase binding	Dock10	IPI	PR:P60766	Mouse	PMID:15710388
Molecular Function	GO:0031267	small GTPase binding	Dock10	IPI	PR:Q9ER71	Mouse	PMID:15710388
Cellular Component	GO:0005737	cytoplasm	DOCK10	IDA		Human	PMID:18499258
Cellular Component	GO:0005829	cytosol	DOCK10	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043197	dendritic spine	Dock10	IDA		Mouse	MGI:MGI:5825418|PMID:25851601
Cellular Component	GO:0070062	extracellular exosome	DOCK10	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Dock10	IDA		Mouse	PMID:25851601
Cellular Component	GO:0098978	glutamatergic synapse	Dock10	IEP		Mouse	PMID:25851601
Cellular Component	GO:0016020	membrane	DOCK10	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	DOCK10	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	DOCK10	IDA		Human	PMID:18499258
Cellular Component	GO:0098794	postsynapse	Dock10	IDA		Mouse	PMID:25851601
Cellular Component	GO:0098794	postsynapse	Dock10	IEP		Mouse	PMID:25851601
Biological Process	GO:0001782	B cell homeostasis	Dock10	IMP		Mouse	MGI:MGI:5818419|PMID:25729399
Biological Process	GO:0001782	B cell homeostasis	Dock10	IMP		Mouse	MGI:MGI:5810214|PMID:27502165
Biological Process	GO:0060997	dendritic spine morphogenesis	Dock10	IMP		Mouse	MGI:MGI:5825418|PMID:25851601
Biological Process	GO:0002315	marginal zone B cell differentiation	Dock10	IMP		Mouse	MGI:MGI:5818419|PMID:25729399
Biological Process	GO:0043547	positive regulation of GTPase activity	Dock10	IDA		Mouse	MGI:MGI:5825418|PMID:25851601
Biological Process	GO:0030334	regulation of cell migration	DOCK10	IDA		Human	PMID:18835169

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern