Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DOC2B
  • Mouse genes Doc2b
  • Rat genes Doc2b
  • Zfish genes doc2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Doc2b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	Doc2b	IDA		Mouse	PMID:21521611
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Doc2b	IDA		Rat	PMID:18596155|RGD:8554556
Molecular Function	GO:0005544	calcium-dependent phospholipid binding	Doc2b	IDA		Rat	PMID:20150444|RGD:8554647
Molecular Function	GO:0005515	protein binding	Doc2b	IPI	UniProtKB:Q60770	Mouse	MGI:MGI:4457249|PMID:17548353
Molecular Function	GO:0019905	syntaxin binding	Doc2b	IPI	UniProtKB:P70452	Mouse	MGI:MGI:3838942|PMID:19033398
Cellular Component	GO:0005737	cytoplasm	Doc2b	IDA		Mouse	MGI:MGI:3838942|PMID:19033398
Cellular Component	GO:0098850	extrinsic component of synaptic vesicle membrane	Doc2b	IDA		Rat	PMID:9115738|RGD:1357915
Cellular Component	GO:0098978	glutamatergic synapse	Doc2b	IDA		Rat	PMID:22036572|RGD:155230732
Cellular Component	GO:0098978	glutamatergic synapse	Doc2b	IMP		Rat	PMID:22036572|RGD:155230732
Cellular Component	GO:0005886	plasma membrane	Doc2b	IDA		Mouse	MGI:MGI:3838942|PMID:19033398
Cellular Component	GO:0005886	plasma membrane	Doc2b	IDA		Rat	PMID:18596155|RGD:8554556
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	Doc2b	IMP		Mouse	MGI:MGI:4439222|PMID:20150444
Biological Process	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	Doc2b	IDA		Rat	PMID:20150444|RGD:8554647
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Doc2b	IDA		Mouse	PMID:20150444
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Doc2b	IMP		Mouse	PMID:20150444
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Doc2b	IDA		Rat	PMID:22036572|RGD:155230732
Biological Process	GO:0099502	calcium-dependent activation of synaptic vesicle fusion	Doc2b	IMP		Rat	PMID:22036572|RGD:155230732
Biological Process	GO:0006887	exocytosis	Doc2b	IEP		Rat	PMID:10651871|RGD:1357914
Biological Process	GO:0045956	positive regulation of calcium ion-dependent exocytosis	Doc2b	IDA		Rat	PMID:18596155|RGD:8554556
Biological Process	GO:0032024	positive regulation of insulin secretion	Doc2b	IMP		Mouse	MGI:MGI:4457249|PMID:17548353
Biological Process	GO:0031340	positive regulation of vesicle fusion	Doc2b	IDA		Rat	PMID:18596155|RGD:8554556
Biological Process	GO:0008104	protein localization	Doc2b	IMP		Mouse	MGI:MGI:3838942|PMID:19033398
Biological Process	GO:0061669	spontaneous neurotransmitter secretion	Doc2b	IGI	MGI:MGI:102788,MGI:MGI:109446,MGI:MGI:1926250	Mouse	PMID:21521611
Biological Process	GO:0061669	spontaneous neurotransmitter secretion	Doc2b	IDA		Mouse	PMID:21521611

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern