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Doc2b
Gene Detail
Symbol

Name
ID
Doc2b
double C2, beta
MGI:1100497
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:75768966-75796049 bp, - strand
From VEGA annotation of GRCm38

  27084 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20796  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DOC2B
Protein SuperFamily: double C2 protein, alpha/beta/gamma types
Gene Tree: Doc2b

Human
homologs
DOC2B, double C2-like domains, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8447
neXtProt AC: NX_Q14184

Human Synonyms: DOC2BL

Human Chr (Location): 17p13.3; chr17:143688-181630 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Doc2b (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit a reduced frequency of spontaneous neurotransmitter release events with cerebellar Purkinje cells showing continuous spiking without interruption.
 
Interactions
Doc2b interacts with 270 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (15)    Tissues (5)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 13
Western blot 2
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000006220 (Evidence)
Ensembl Gene Model ENSMUSG00000020848 (Evidence)
Entrez Gene 13447 (Evidence)
UniGene 5137
DFCI TC1586126
DoTS DT.91444214
NIA Mouse Gene Index U033089
Consensus CDS Project CCDS25057.1
International Mouse Phenotyping Consortium Status Doc2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006220 VEGA Gene Model | MGI Sequence Detail 27084 C57BL/6J ±  kb
transcript OTTMUST00000014046 VEGA | MGI Sequence Detail 4361 Not Applicable 
polypeptide OTTMUSP00000006522 VEGA | MGI Sequence Detail 412 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR014638 Double C2 protein, alpha/beta/gamma type
InterPro IPR001565 Synaptotagmin
Protein Ontology PR:000006615 double C2-like domain-containing protein beta
References
(Earliest) J:39762 Kojima T, et al., Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta). J Biochem. 1996 Sep;120(3):671-6
(Latest) J:218125 Li J, et al., DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. Diabetologia. 2014 Oct;57(10):2173-82
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory