Doc2b
Gene Detail

Symbol Name ID

Doc2b double C2, beta MGI:1100497

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:75768966-75796049 bp, - strand From VEGA annotation of GRCm38   27084 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20796  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: double C2 protein, alpha/beta/gamma types
Gene Tree: Doc2b

Human homologs

Human Homolog		DOC2B, double C2-like domains, beta
NCBI Gene ID		8447
neXtProt AC		NX_Q14184
Human Synonyms		DOC2BL
Human Chr (Location)		17p13.3; chr17:6009-31420 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit a reduced frequency of spontaneous neurotransmitter release events with cerebellar Purkinje cells showing continuous spiking without interruption.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	calcium ion-dependent exocytosis of neurotransmitter, positive regulation of calcium ion-dependent exocytosis, ...
Component	cytoplasm, membrane, ...
Function	calcium-dependent phospholipid binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (15)    Tissues (5)    Images (10)
Theiler Stages: 23, 26

Assay Type	Results
RNA in situ	13
Western blot	2

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(22)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000006220 (Evidence)
Ensembl Gene Model	ENSMUSG00000020848 (Evidence)
Entrez Gene	13447 (Evidence)
UniGene	5137
DFCI	TC1586126
DoTS	DT.91444214
NIA Mouse Gene Index	U033089
Consensus CDS Project	CCDS25057.1
International Mouse Knockout Project Status	Doc2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006220	VEGA Gene Model | MGI Sequence Detail	27084	C57BL/6J
transcript	OTTMUST00000014046	VEGA | MGI Sequence Detail	4361	Not Applicable
polypeptide	OTTMUSP00000006522	VEGA | MGI Sequence Detail	412	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR020477	C2 domain
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR014638	Double C2 protein, alpha/beta/gamma type
InterPro	IPR001565	Synaptotagmin
Protein Ontology	PR:000006615	double C2-like domain-containing protein beta

References

(Earliest) J:39762 Kojima T, et al., Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta). J Biochem. 1996 Sep;120(3):671-6
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(35)