Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DNMT3L
  • Mouse genes Dnmt3l
  • Rat genes Dnmt3l
  • Zfish genes dnmt3ba,dnmt3bb.2,dnmt3bb.3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dnmt3l

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008047	enzyme activator activity	DNMT3L	IDA		Human	PMID:16543361
Molecular Function	GO:0008047	enzyme activator activity	Dnmt3l	IDA		Mouse	PMID:16543361
Molecular Function	GO:0019899	enzyme binding	DNMT3L	IPI	UniProtKB:Q13547	Human	PMID:12202768
Molecular Function	GO:0005515	protein binding	DNMT3L	IPI	UniProtKB:Q13547	Human	PMID:12202768
Molecular Function	GO:0005515	protein binding	DNMT3L	IPI	UniProtKB:Q9UHA3	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	DNMT3L	IPI	UniProtKB:Q9Y6K1	Human	PMID:17713477
Molecular Function	GO:0005515	protein binding	DNMT3L	IPI	UniProtKB:Q9UHA3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	DNMT3L	IPI	UniProtKB:Q17RL8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	DNMT3L	IPI	UniProtKB:Q9UHA3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	UniProtKB:O88509	Mouse	MGI:MGI:3719491|PMID:17687327
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	UniProtKB:O88508|UniProtKB:O88509|UniProtKB:Q15910|UniProtKB:Q61188	Mouse	MGI:MGI:5553039|PMID:24074865
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	UniProtKB:O88508-1	Mouse	MGI:MGI:5919006|PMID:17713477
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	UniProtKB:O88508-1	Mouse	MGI:MGI:3719491|PMID:17687327
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	UniProtKB:B1ASB6	Mouse	MGI:MGI:6453929|PMID:32674113
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	PR:O88508	Mouse	PMID:17938196
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	PR:O88509	Mouse	PMID:11934864
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	PR:O88509	Mouse	PMID:17938196
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	PR:O88508	Mouse	PMID:11934864
Molecular Function	GO:0005515	protein binding	Dnmt3l	IPI	PR:O88509	Mouse	PMID:16543361
Cellular Component	GO:1902494	catalytic complex	DNMT3L	IPI		Human	PMID:25383530
Cellular Component	GO:1902494	catalytic complex	DNMT3L	IPI		Human	PMID:32083663
Cellular Component	GO:0000794	condensed nuclear chromosome	Dnmt3l	IDA		Mouse	PMID:16543361
Cellular Component	GO:0005737	cytoplasm	Dnmt3l	IDA		Mouse	PMID:16543361
Cellular Component	GO:0005737	cytoplasm	Dnmt3l	IDA		Mouse	PMID:11934864
Cellular Component	GO:0005829	cytosol	DNMT3L	HDA		Human	PMID:16780588
Cellular Component	GO:0035098	ESC/E(Z) complex	Dnmt3l	IDA		Mouse	MGI:MGI:5553039|PMID:24074865
Cellular Component	GO:0000792	heterochromatin	Dnmt3l	IDA		Mouse	PMID:11934864
Cellular Component	GO:0005634	nucleus	DNMT3L	HDA		Human	PMID:16780588
Cellular Component	GO:0005634	nucleus	Dnmt3l	IDA		Mouse	PMID:27856912
Biological Process	GO:0090116	C-5 methylation of cytosine	DNMT3L	IDA		Human	PMID:25383530
Biological Process	GO:0090116	C-5 methylation of cytosine	DNMT3L	IDA		Human	PMID:32083663
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	Dnmt3l	IMP	MGI:MGI:2447127	Mouse	PMID:16920095
Biological Process	GO:0061371	determination of heart left/right asymmetry	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5,ZFIN:ZDB-MRPHLNO-200323-11	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	dnmt3bb.2	IMP	ZFIN:ZDB-GENO-210129-2	Zfish	PMID:31513014
Biological Process	GO:0061371	determination of heart left/right asymmetry	dnmt3ba	IMP	ZFIN:ZDB-GENO-210129-3	Zfish	PMID:31513014
Biological Process	GO:0006306	DNA methylation	Dnmt3l	IMP	MGI:MGI:2155766	Mouse	PMID:25503965
Biological Process	GO:0006306	DNA methylation	dnmt3ba	IMP	ZFIN:ZDB-MRPHLNO-050809-10	Zfish	PMID:15937923
Biological Process	GO:0006306	DNA methylation	dnmt3ba	IMP	ZFIN:ZDB-MRPHLNO-050809-9	Zfish	PMID:15937923
Biological Process	GO:0043046	DNA methylation involved in gamete generation	Dnmt3l	IMP		Mouse	MGI:MGI:3054275|PMID:15318244
Biological Process	GO:0032776	DNA methylation on cytosine	Dnmt3l	IMP		Mouse	MGI:MGI:3054275|PMID:15318244
Biological Process	GO:0032776	DNA methylation on cytosine	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0031017	exocrine pancreas development	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0042462	eye photoreceptor cell development	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0071514	genomic imprinting	Dnmt3l	IMP	MGI:MGI:2447127	Mouse	PMID:16920095
Biological Process	GO:0001701	in utero embryonic development	Dnmt3l	IMP	MGI:MGI:2447128	Mouse	PMID:11934864
Biological Process	GO:0001701	in utero embryonic development	Dnmt3l	IMP	MGI:MGI:2447127	Mouse	PMID:11934864
Biological Process	GO:0007141	male meiosis I	Dnmt3l	IMP		Mouse	MGI:MGI:3054275|PMID:15318244
Biological Process	GO:0032259	methylation	Dnmt3l	IMP	MGI:MGI:2447127	Mouse	PMID:16920095
Biological Process	GO:1905642	negative regulation of DNA methylation	Dnmt3l	IMP		Mouse	MGI:MGI:5553039|PMID:24074865
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	DNMT3L	IDA		Human	PMID:12202768
Biological Process	GO:0010529	negative regulation of transposition	Dnmt3l	IMP	MGI:MGI:2155766	Mouse	PMID:25503965
Biological Process	GO:0022008	neurogenesis	dnmt3bb.2	IGI	ZFIN:ZDB-MRPHLNO-050809-5,ZFIN:ZDB-MRPHLNO-060214-6	Zfish	PMID:19946145
Biological Process	GO:0022008	neurogenesis	dnmt3bb.2	IGI	ZFIN:ZDB-MRPHLNO-050809-5,ZFIN:ZDB-MRPHLNO-100524-11	Zfish	PMID:19946145
Biological Process	GO:0022008	neurogenesis	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0060037	pharyngeal system development	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0001890	placenta development	Dnmt3l	IMP	MGI:MGI:2447127	Mouse	PMID:16920095
Biological Process	GO:1905643	positive regulation of DNA methylation	Dnmt3l	IMP		Mouse	MGI:MGI:5553039|PMID:24074865
Biological Process	GO:0051570	regulation of histone H3-K9 methylation	dnmt3bb.2	IGI	ZFIN:ZDB-MRPHLNO-050809-5,ZFIN:ZDB-MRPHLNO-100524-10	Zfish	PMID:19946145
Biological Process	GO:0045471	response to ethanol	Dnmt3l	IEP		Rat	PMID:24968059|RGD:9588611
Biological Process	GO:0010842	retina layer formation	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	dnmt3bb.2	IMP	ZFIN:ZDB-MRPHLNO-050809-5	Zfish	PMID:19946145
Biological Process	GO:0007283	spermatogenesis	Dnmt3l	IMP		Mouse	MGI:MGI:3054275|PMID:15318244
Biological Process	GO:0007283	spermatogenesis	Dnmt3l	IMP	MGI:MGI:2155766	Mouse	PMID:25503965
Biological Process	GO:0048863	stem cell differentiation	Dnmt3l	IMP		Mouse	MGI:MGI:5553039|PMID:24074865

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern