Dnmt3l
Gene Detail

Symbol Name ID

Dnmt3l DNA (cytosine-5-)-methyltransferase 3-like MGI:1859287

Synonyms

D6Ertd14e, ecat7

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:78041947-78063622 bp, + strand From VEGA annotation of GRCm38   21676 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8362  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dnmt3l

Human homologs

Human Homolog		DNMT3L, DNA (cytosine-5-)-methyltransferase 3-like
NCBI Gene ID		29947
neXtProt AC		NX_Q9UJW3
Human Chr (Location)		21q22.3; chr21:45666222-45682099 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(42) : Targeted(7) Gene trapped(35)
 

Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	chorionic trophoblast cell differentiation, genetic imprinting, ...
Component	condensed nuclear chromosome, cytoplasm, ...
Function	enzyme activator activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (321)    Tissues (157)    Images (27)
Theiler Stages: 1, 2, 3, 4, 10, 11, 13, 15, 17, 18, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	193
In situ reporter (knock in)	2
Northern blot	20
Western blot	6
RT-PCR	94

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(1) cDNA(28) Primer pair(9)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000034125 (Evidence)
Ensembl Gene Model	ENSMUSG00000000730 (Evidence)
Entrez Gene	54427 (Evidence)
UniGene	13433
DFCI	TC1584201
DoTS	DT.101269838, DT.525490, DT.91562143, DT.94277437
NIA Mouse Gene Index	U011694
Consensus CDS Project	CCDS23962.1
International Mouse Knockout Project Status	Dnmt3l

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034125	VEGA Gene Model | MGI Sequence Detail	21676	C57BL/6J
transcript	OTTMUST00000086336	VEGA | MGI Sequence Detail	1822	Not Applicable
polypeptide	OTTMUSP00000046736	VEGA | MGI Sequence Detail	421	Not Applicable

All sequences(60) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(56 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025766	ADD domain
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000006609	DNA (cytosine-5)-methyltransferase 3-like

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:194075 Guenatri M, et al., Plasticity in Dnmt3L-dependent and -independent modes of de novo methylation in the developing mouse embryo. Development. 2013 Feb 1;140(3):562-72
All references(96)

Other accession IDs

MGI:1098798