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Dnmt3l Gene Detail
Summary
  • Symbol
    Dnmt3l
  • Name
    DNA (cytosine-5-)-methyltransferase 3-like
  • Synonyms
    D6Ertd14e, ecat7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859287
    NCBI Gene: 54427
Location & Maps
more
  • Sequence Map
    Chr10:78041947-78063622 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21676 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DNMT3L, DNA (cytosine-5-)-methyltransferase 3-like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DNMT3L, DNA (cytosine-5-)-methyltransferase 3-like
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 29947
    neXtProt AC: NX_Q9UJW3

  • Chr Location
    21q22.3; chr21:44246339-44267138 (-)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    1
  • Gene trapped
    35
  • Targeted
    11
  • Genomic Mutations
    4 involving Dnmt3l
  • Incidental Mutations
Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034125 VEGA Gene Model | MGI Sequence Detail 21676 C57BL/6J ±  kb
transcript OTTMUST00000086336 VEGA | MGI Sequence Detail 1822 Not Applicable  
polypeptide OTTMUSP00000046736 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006609 DNA (cytosine-5)-methyltransferase 3-like
  • InterPro Domains
    IPR025766 ADD domain
    IPR030486 DNA (cytosine-5)-methyltransferase 3-like
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 41
    Genomic 1
    cDNA 28
    Primer pair 11
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:1098798
References
more
  • Summaries
    All 110
    Developmental Gene Expression 46
    Diseases 2
    Gene Ontology 10
    Phenotypes 47
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:226694 Matsuzaki H, et al., De novo DNA methylation through the 5'-segment of the H19 ICR maintains its imprint during early embryogenesis. Development. 2015 Nov 15;142(22):3833-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory