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Dnmt3l
Gene Detail
Symbol

Name
ID
Dnmt3l
DNA (cytosine-5-)-methyltransferase 3-like
MGI:1859287
Synonyms
D6Ertd14e, ecat7
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:78041947-78063622 bp, + strand
From VEGA annotation of GRCm38

  21676 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8362  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: DNMT3L
Gene Tree: Dnmt3l

Human
homologs
DNMT3L, DNA (cytosine-5-)-methyltransferase 3-like
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29947
neXtProt AC: NX_Q9UJW3

Human Chr (Location): 21q22.3; chr21:44246339-44267138 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(35) Targeted(11)
Genomic Mutations involving Dnmt3l (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutants in this imprinted gene lack appropriate methylation of the maternal allele and this, in turn, causes azoospermia in homozygous males; and heterozygous progeny of homozygous females die by midgestation.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Dnmt3l interacts with 41 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process chorionic trophoblast cell differentiation, DNA methylation, ...
Component condensed nuclear chromosome, cytoplasm, ...
Function enzyme activator activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (340)    Tissues (169)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 195
In situ reporter (knock in) 2
Northern blot 20
Western blot 6
RT-PCR 111
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(28) Primer pair(11) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000034125 (Evidence)
Ensembl Gene Model ENSMUSG00000000730 (Evidence)
Entrez Gene 54427 (Evidence)
UniGene 13433
DFCI TC1584201
DoTS DT.101269838, DT.525490, DT.91562143, DT.94277437
NIA Mouse Gene Index U011694
Consensus CDS Project CCDS23962.1, CCDS70061.1
International Mouse Phenotyping Consortium Status Dnmt3l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034125 VEGA Gene Model | MGI Sequence Detail 21676 C57BL/6J ±  kb
transcript OTTMUST00000086336 VEGA | MGI Sequence Detail 1822 Not Applicable 
polypeptide OTTMUSP00000046736 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025766 ADD domain
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000006609 DNA (cytosine-5)-methyltransferase 3-like
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:220472 Zhao L, et al., Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1. Development. 2015 Mar 15;142(6):1083-8
All references(112)
Other
accession IDs
MGI:1098798

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory