Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DKC1
  • Mouse genes Dkc1
  • Rat genes Dkc1
  • Zfish genes dkc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dkc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034513	box H/ACA snoRNA binding	DKC1	IPI	RNAcentral:URS0000210FD6_9606	Human	PMID:18082603
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q96HR8	Human	PMID:16601202
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q96HR8	Human	PMID:16618814
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q9Y265	Human	PMID:18358808
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q96HR8	Human	PMID:19179534
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q9BUR4	Human	PMID:19179534
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q9Y265	Human	PMID:19179534
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q6PI26	Human	PMID:19383767
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q9H2U1	Human	PMID:21846770
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q6NT76	Human	PMID:23685356
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:P19712:PRO_0000038050	Human	PMID:24965446
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q9BUR4	Human	PMID:25467444
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q96HR8	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q6PI26	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q96HR8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q9Y265	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	DKC1	IPI	UniProtKB:Q6PI26	Human	PMID:29178645
Molecular Function	GO:0005515	protein binding	Dkc1	IPI	UniProtKB:Q8BJA3	Mouse	MGI:MGI:5500098|PMID:23685356
Molecular Function	GO:0005515	protein binding	Dkc1	IPI	RGD:1563995	Rat	PMID:12446766|RGD:633420
Molecular Function	GO:0005515	protein binding	Dkc1	IPI	RGD:1582780	Rat	PMID:15044956|RGD:10766448
Molecular Function	GO:0005515	protein binding	Dkc1	IPI	UniProtKB:D3ZMP6	Rat	PMID:16618814|RGD:8554465
Molecular Function	GO:0005515	protein binding	Dkc1	IPI	UniProtKB:Q96HR8	Rat	PMID:16618814|RGD:8554465
Molecular Function	GO:0005515	protein binding	Dkc1	IPI	RGD:621578	Rat	PMID:7798307|RGD:728589
Molecular Function	GO:0009982	pseudouridine synthase activity	DKC1	IMP		Human	PMID:25219674
Molecular Function	GO:0003723	RNA binding	DKC1	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:18082603
Molecular Function	GO:0003723	RNA binding	DKC1	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:20351177
Molecular Function	GO:0003723	RNA binding	DKC1	IPI	RNAcentral:URS00004416C5_9606	Human	PMID:22527283
Molecular Function	GO:0003723	RNA binding	DKC1	HDA		Human	PMID:22658674
Molecular Function	GO:0003720	telomerase activity	DKC1	IDA		Human	PMID:23685356
Molecular Function	GO:0003720	telomerase activity	DKC1	IDA		Human	PMID:12135483
Molecular Function	GO:0070034	telomerase RNA binding	DKC1	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:18082603
Molecular Function	GO:0070034	telomerase RNA binding	DKC1	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:20351177
Molecular Function	GO:0070034	telomerase RNA binding	DKC1	IPI	RNAcentral:URS00004A7003_9606	Human	PMID:22527283
Cellular Component	GO:0031429	box H/ACA snoRNP complex	DKC1	IDA		Human	PMID:18082603
Cellular Component	GO:0031429	box H/ACA snoRNP complex	Dkc1	IDA		Rat	PMID:10679015|RGD:633515
Cellular Component	GO:0031429	box H/ACA snoRNP complex	Dkc1	IDA		Rat	PMID:12446766|RGD:633420
Cellular Component	GO:0090661	box H/ACA telomerase RNP complex	DKC1	IDA		Human	PMID:18082603
Cellular Component	GO:0015030	Cajal body	Dkc1	IDA		Mouse	PMID:23726835
Cellular Component	GO:0015030	Cajal body	Dkc1	IDA		Rat	PMID:7798307|RGD:728589
Cellular Component	GO:0001650	fibrillar center	DKC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	Dkc1	IDA		Mouse	PMID:23726835
Cellular Component	GO:0005730	nucleolus	Dkc1	IDA		Rat	PMID:7798307|RGD:728589
Cellular Component	GO:0005654	nucleoplasm	DKC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	Dkc1	IDA		Rat	PMID:7798307|RGD:728589
Cellular Component	GO:0005634	nucleus	DKC1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005697	telomerase holoenzyme complex	DKC1	IDA		Human	PMID:12135483
Cellular Component	GO:0005697	telomerase holoenzyme complex	DKC1	IDA		Human	PMID:18082603
Cellular Component	GO:0005697	telomerase holoenzyme complex	DKC1	IDA		Human	PMID:29695869
Biological Process	GO:0033979	box H/ACA RNA metabolic process	Dkc1	IMP	MGI:MGI:2446500	Mouse	PMID:23726835
Biological Process	GO:0060216	definitive hemopoiesis	dkc1	IMP	ZFIN:ZDB-MRPHLNO-120210-6	Zfish	PMID:22299032
Biological Process	GO:0060216	definitive hemopoiesis	dkc1	IGI	ZFIN:ZDB-MRPHLNO-070126-7,ZFIN:ZDB-MRPHLNO-120210-6	Zfish	PMID:22299032
Biological Process	GO:0000455	enzyme-directed rRNA pseudouridine synthesis	DKC1	IMP		Human	PMID:25219674
Biological Process	GO:0008284	positive regulation of cell population proliferation	Dkc1	IDA		Rat	PMID:10679015|RGD:633515
Biological Process	GO:1904851	positive regulation of establishment of protein localization to telomere	DKC1	IMP		Human	PMID:25467444
Biological Process	GO:1904871	positive regulation of protein localization to Cajal body	DKC1	HMP		Human	PMID:25467444
Biological Process	GO:0051973	positive regulation of telomerase activity	DKC1	IMP		Human	PMID:25467444
Biological Process	GO:0051973	positive regulation of telomerase activity	Dkc1	IMP	MGI:MGI:3849598	Mouse	PMID:15240872
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	DKC1	HMP		Human	PMID:25467444
Biological Process	GO:1904874	positive regulation of telomerase RNA localization to Cajal body	DKC1	IMP		Human	PMID:25467444
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	Dkc1	IMP	MGI:MGI:3849598	Mouse	PMID:15240872
Biological Process	GO:1904872	regulation of telomerase RNA localization to Cajal body	DKC1	IMP		Human	PMID:26950371
Biological Process	GO:0006364	rRNA processing	dkc1	IMP	ZFIN:ZDB-MRPHLNO-120210-6	Zfish	PMID:22299032
Biological Process	GO:0031118	rRNA pseudouridine synthesis	Dkc1	IMP	MGI:MGI:3849598	Mouse	PMID:15240872
Biological Process	GO:0031118	rRNA pseudouridine synthesis	Dkc1	IMP	MGI:MGI:3849599	Mouse	PMID:15240872
Biological Process	GO:0031118	rRNA pseudouridine synthesis	Dkc1	IMP	MGI:MGI:2446500	Mouse	PMID:23726835
Biological Process	GO:0090666	scaRNA localization to Cajal body	DKC1	IMP		Human	PMID:25467444
Biological Process	GO:0000454	snoRNA guided rRNA pseudouridine synthesis	Dkc1	IDA		Rat	PMID:12446766|RGD:633420
Biological Process	GO:0090669	telomerase RNA stabilization	DKC1	IMP		Human	PMID:25467444
Biological Process	GO:0090669	telomerase RNA stabilization	DKC1	IMP		Human	PMID:26950371
Biological Process	GO:0007004	telomere maintenance via telomerase	DKC1	IDA		Human	PMID:23685356
Biological Process	GO:0007004	telomere maintenance via telomerase	DKC1	IMP	GO:0090669	Human	PMID:26950371
Biological Process	GO:0007004	telomere maintenance via telomerase	DKC1	IDA		Human	PMID:29695869

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern