Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DIO2
  • Mouse genes Dio2
  • Rat genes Dio2
  • Zfish genes dio2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dio2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	DIO2	IDA		Human	PMID:19651899
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	Dio2	IDA		Mouse	MGI:MGI:3691903|PMID:12586753
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	Dio2	IMP	MGI:MGI:2182450	Mouse	PMID:11731615
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	Dio2	IDA		Rat	PMID:11934678|RGD:628323
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	Dio2	IDA		Rat	PMID:15550511|RGD:1626436
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	dio2	IMP	ZFIN:ZDB-GENO-170119-3	Zfish	PMID:27580812
Molecular Function	GO:0004800	thyroxine 5'-deiodinase activity	dio2	IMP	ZFIN:ZDB-GENO-170119-2	Zfish	PMID:27580812
Molecular Function	GO:0033798	thyroxine 5-deiodinase activity	DIO2	IDA		Human	PMID:18566113
Molecular Function	GO:0031625	ubiquitin protein ligase binding	DIO2	IPI	UniProtKB:O60337	Human	PMID:19651899
Biological Process	GO:0050873	brown fat cell differentiation	Dio2	IDA		Mouse	PMID:28763438
Biological Process	GO:0044255	cellular lipid metabolic process	Dio2	IMP	MGI:MGI:5513859	Mouse	PMID:29320745
Biological Process	GO:0043009	chordate embryonic development	dio2	IMP	ZFIN:ZDB-MRPHLNO-091028-1,ZFIN:ZDB-MRPHLNO-100525-3	Zfish	PMID:23603432
Biological Process	GO:0043009	chordate embryonic development	dio2	IMP	ZFIN:ZDB-MRPHLNO-091028-1	Zfish	PMID:18801906
Biological Process	GO:0043009	chordate embryonic development	dio2	IMP	ZFIN:ZDB-MRPHLNO-091028-2	Zfish	PMID:18801906
Biological Process	GO:0048589	developmental growth	dio2	IMP	ZFIN:ZDB-GENO-170119-3	Zfish	PMID:27580812
Biological Process	GO:0048589	developmental growth	dio2	IMP	ZFIN:ZDB-GENO-170119-2	Zfish	PMID:27580812
Biological Process	GO:0048066	developmental pigmentation	dio2	IMP	ZFIN:ZDB-MRPHLNO-091028-1	Zfish	PMID:18801906
Biological Process	GO:0048066	developmental pigmentation	dio2	IMP	ZFIN:ZDB-MRPHLNO-091028-2	Zfish	PMID:18801906
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Dio2	IMP		Mouse	MGI:MGI:2182382|PMID:11696583
Biological Process	GO:0061074	regulation of neural retina development	dio2	IGI	ZFIN:ZDB-MRPHLNO-091028-1,ZFIN:ZDB-MRPHLNO-100525-3	Zfish	PMID:26802877
Biological Process	GO:0000003	reproduction	dio2	IMP	ZFIN:ZDB-GENO-170119-3	Zfish	PMID:27580812
Biological Process	GO:0000003	reproduction	dio2	IMP	ZFIN:ZDB-GENO-170119-2	Zfish	PMID:27580812
Biological Process	GO:0009409	response to cold	Dio2	IDA		Rat	PMID:11934678|RGD:628323
Biological Process	GO:0009725	response to hormone	dio2	IDA		Zfish	PMID:17418841
Biological Process	GO:0032496	response to lipopolysaccharide	Dio2	IEP		Rat	PMID:16095572|RGD:2313697
Biological Process	GO:0042404	thyroid hormone catabolic process	Dio2	IMP	MGI:MGI:2182450	Mouse	PMID:11731615
Biological Process	GO:0006590	thyroid hormone generation	Dio2	IDA		Rat	PMID:15550511|RGD:1626436
Biological Process	GO:0042403	thyroid hormone metabolic process	DIO2	IDA		Human	PMID:19651899
Biological Process	GO:0042403	thyroid hormone metabolic process	Dio2	IDA		Rat	PMID:15550511|RGD:1626436

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern