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Dio2
Gene Detail
 Symbol
Name
ID
Dio2
deiodinase, iodothyronine, type II
MGI:1338833
Feature Type protein coding gene
Genetic Map
Chromosome 12
44.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:90724554-90738438 bp, - strand
From Ensembl annotation of GRCm38

  13885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: iodothyronine deiodinase
Gene Tree: Dio2

Human
homologs
Human Homolog DIO2, deiodinase, iodothyronine, type II
NCBI Gene ID 1734
neXtProt AC  NX_Q92813
Human Synonyms  5DII, D2, DIOII, SelY, TXDI2
Human Chr (Location)  14q24.2-q24.3; chr14:80197525-80231054 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display elevated thyroxine (T4) and thyroid-stimulating hormone levels and changes in the metabolism and excretion of iodothyronines.
 
Interactions
Dio2 interacts with 427 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process hormone biosynthetic process, oxidation-reduction process, ...
Component cell, integral component of membrane, ...
Function oxidoreductase activity, thyroxine 5'-deiodinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (136)    Tissues (112)    Images (5)
Theiler Stages: 22, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 119
RT-PCR 17
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000007682 (Evidence)
Entrez Gene13371 (Evidence)
DFCITC1587961, TC1590477, TC1636620, TC1728254
DoTSDT.55194044
NIA Mouse Gene IndexU034224
EC1.97.1.10
Consensus CDS ProjectCCDS36514.1
International Mouse Knockout Project StatusDio2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007682 Ensembl Gene Model | MGI Sequence Detail 13885 C57BL/6J ±  kb
transcript ENSMUST00000082432 Ensembl | MGI Sequence Detail 5813 Not Applicable 
polypeptide ENSMUSP00000081013 Ensembl | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000643 Iodothyronine deiodinase
InterPro IPR008261 Iodothyronine deiodinase, active site
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000006481 type II iodothyronine deiodinase
References (Earliest) J:52912 Davey JC, et al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase. Endocrinology. 1999 Feb;140(2):1022-5
(Latest) J:209042 Rodrigues TB, et al., Increased oxidative metabolism and neurotransmitter cycling in the brain of mice lacking the thyroid hormone transporter SLC16A2 (MCT8). PLoS One. 2013;8(10):e74621
All references(58)
Other
accession IDs
MGI:2144791

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory