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Dio2 Gene Detail
Summary
  • Symbol
    Dio2
  • Name
    deiodinase, iodothyronine, type II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338833
    NCBI Gene: 13371
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:90691326-90705812 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 44.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338833
 protein coding gene Chr12:90691326-90705812 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019996
 protein coding gene Chr12:91854121-91868018 (-)
A/J MGP_AJ_G0019951
 protein coding gene Chr12:88406809-88420702 (-)
AKR/J MGP_AKRJ_G0019927
 protein coding gene Chr12:90759270-90773154 (-)
BALB/cJ MGP_BALBcJ_G0019937
 protein coding gene Chr12:88696584-88710468 (-)
C3H/HeJ MGP_C3HHeJ_G0019739
 protein coding gene Chr12:91398954-91412847 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020386
 protein coding gene Chr12:94556955-94570839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018000
 protein coding gene Chr12:85900865-85914643 (-)
CAST/EiJ MGP_CASTEiJ_G0019286
 protein coding gene Chr12:86312380-86326294 (-)
CBA/J MGP_CBAJ_G0019711
 protein coding gene Chr12:98121531-98135460 (-)
DBA/2J MGP_DBA2J_G0019822
 protein coding gene Chr12:87883534-87897427 (-)
FVB/NJ MGP_FVBNJ_G0019811
 protein coding gene Chr12:86763103-86777032 (-)
LP/J MGP_LPJ_G0019898
 protein coding gene Chr12:91662453-91676382 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019852
 protein coding gene Chr12:100884495-100898430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020415
 protein coding gene Chr12:90394977-90408906 (-)
PWK/PhJ MGP_PWKPhJ_G0019049
 protein coding gene Chr12:82476053-82490038 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018845
 protein coding gene Chr12:84550980-84564875 (-)
WSB/EiJ MGP_WSBEiJ_G0019339
 protein coding gene Chr12:91121817-91135746 (-)



Homology
more
  • Human Ortholog
    DIO2, iodothyronine deiodinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIO2, iodothyronine deiodinase 2
  • Synonyms
    5DII, D2, DIOII, SELENOY, SelY, TXDI2
  • Links
    NCBI Gene ID: 1734
    UniProt: Q92813

  • Chr Location
    14q31.1; chr14:80197526-80387757 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DIO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display elevated thyroxine (T4) and thyroid-stimulating hormone levels, changes in the metabolism and excretion of iodothyronines, and impaired adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    132
  • cDNA Data
    13
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13371 NCBI Gene Model | MGI Sequence Detail 14487 C57BL/6J ±  kb
    transcript NM_010050 RefSeq | MGI Sequence Detail 6433 C57BL/6  
    polypeptide Q9Z1Y9 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 15
      Primer pair 11
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144791
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 36
      Gene Ontology 16
      Phenotypes 61
    • Earliest
      J:52912 Davey JC, et al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase. Endocrinology. 1999 Feb;140(2):1022-5
    • Latest
      J:364614 Batistuzzo A, et al., FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter. Endocrinology. 2025 Mar 24;166(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory