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Dio2
Gene Detail
Symbol

Name
ID
Dio2
deiodinase, iodothyronine, type II
MGI:1338833
Feature Type
protein coding gene
Genetic Map
Chromosome 12
44.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:90724554-90738438 bp, - strand
From Ensembl annotation of GRCm38

  13885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DIO2
Protein SuperFamily: iodothyronine deiodinase
Gene Tree: Dio2

Human
homologs
DIO2, deiodinase, iodothyronine, type II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1734
neXtProt AC: NX_Q92813

Human Synonyms: 5DII, D2, DIOII, SelY, TXDI2

Human Chr (Location): 14q24.2-q24.3; chr14:80197525-80231054 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display elevated thyroxine (T4) and thyroid-stimulating hormone levels and changes in the metabolism and excretion of iodothyronines.
 
Interactions
Dio2 interacts with 426 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process hormone biosynthetic process, oxidation-reduction process, ...
Component cell, integral component of membrane, ...
Function oxidoreductase activity, thyroxine 5'-deiodinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (136)    Tissues (112)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 119
RT-PCR 17
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dio2 ; ZFIN dio2    NEW 
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000007682 (Evidence)
Entrez Gene 13371 (Evidence)
DFCI TC1587961, TC1590477, TC1636620, TC1728254
DoTS DT.55194044
NIA Mouse Gene Index U034224
EC 1.97.1.10
Consensus CDS Project CCDS36514.1
International Mouse Phenotyping Consortium Status Dio2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007682 Ensembl Gene Model | MGI Sequence Detail 13885 C57BL/6J ±  kb
transcript ENSMUST00000082432 Ensembl | MGI Sequence Detail 5813 Not Applicable 
polypeptide ENSMUSP00000081013 Ensembl | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000643 Iodothyronine deiodinase
InterPro IPR008261 Iodothyronine deiodinase, active site
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000006481 type II iodothyronine deiodinase
References
(Earliest) J:52912 Davey JC, et al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase. Endocrinology. 1999 Feb;140(2):1022-5
(Latest) J:218994 Barez-Lopez S, et al., Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase. PLoS One. 2014;9(8):e103857
All references(62)
Other
accession IDs
MGI:2144791

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory