Dio2
Gene Detail

Symbol

Name
ID

Dio2
deiodinase, iodothyronine, type II
MGI:1338833

Feature Type

protein coding gene

Genetic Map

Chromosome 12
44.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:90724554-90738438 bp, - strand From Ensembl annotation of GRCm38   13885 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:621  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: iodothyronine deiodinase
Gene Tree: Dio2

Human
homologs

Human Homolog		DIO2, deiodinase, iodothyronine, type II
NCBI Gene ID		1734
neXtProt AC		NX_Q92813
Human Synonyms		5DII, D2, DIOII, SelY, TXDI2
Human Chr (Location)		14q24.2-q24.3; chr14:80197525-80231054 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a disruption in this gene display elevated thyroxine (T4) and thyroid-stimulating hormone levels and changes in the metabolism and excretion of iodothyronines.

 

Interactions

Dio2 interacts with 427 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (17 annotations)

Process	hormone biosynthetic process, oxidation-reduction process, ...
Component	cell, integral component of membrane, ...
Function	oxidoreductase activity, thyroxine 5'-deiodinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (136)    Tissues (112)    Images (5)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	119
RT-PCR	17

cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(5)

Other database
links

Ensembl Gene Model	ENSMUSG00000007682 (Evidence)
Entrez Gene	13371 (Evidence)
DFCI	TC1636620, TC1590477, TC1728254, TC1587961
DoTS	DT.55194044
NIA Mouse Gene Index	U034224
EC	1.97.1.10
Consensus CDS Project	CCDS36514.1
International Mouse Knockout Project Status	Dio2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000007682	Ensembl Gene Model | MGI Sequence Detail	13885	C57BL/6J
transcript	ENSMUST00000082432	Ensembl | MGI Sequence Detail	5813	Not Applicable
polypeptide	ENSMUSP00000081013	Ensembl | MGI Sequence Detail	266	Not Applicable

All sequences(30) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(133 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR000643	Iodothyronine deiodinase
InterPro	IPR008261	Iodothyronine deiodinase, active site
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000006481	type II iodothyronine deiodinase

References

(Earliest) J:52912 Davey JC, et al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase. Endocrinology. 1999 Feb;140(2):1022-5
(Latest) J:214159 Galton VA, et al., The 5'-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone. Endocrinology. 2014 Aug;155(8):3172-81
All references(60)

Other
accession IDs

MGI:2144791