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Dio2 Gene Detail
Summary
  • Symbol
    Dio2
  • Name
    deiodinase, iodothyronine, type II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338833
    NCBI Gene: 13371
  • Gene Overview
    MyGene.info: DIO2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:90724552-90738438 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13887 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 44.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DIO2, iodothyronine deiodinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DIO2, iodothyronine deiodinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5DII, D2, DIOII, SelY, TXDI2
  • Links
    NCBI Gene ID: 1734
    neXtProt AC: NX_Q92813
    UniProt: Q92813

  • Chr Location
    14q31.1; chr14:80197525-80231054 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display elevated thyroxine (T4) and thyroid-stimulating hormone levels, changes in the metabolism and excretion of iodothyronines, and impaired adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007682 Ensembl Gene Model | MGI Sequence Detail 13887 C57BL/6J ±  kb
    transcript ENSMUST00000082432 Ensembl | MGI Sequence Detail 5815 Not Applicable  
    polypeptide ENSMUSP00000081013 Ensembl | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      133 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144791
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 16
      Gene Ontology 6
      Phenotypes 41
    • Earliest
      J:52912 Davey JC, et al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase. Endocrinology. 1999 Feb;140(2):1022-5
    • Latest
      J:261405 van der Spek AH, et al., Regulation of Intracellular Triiodothyronine Is Essential for Optimal Macrophage Function. Endocrinology. 2018 May 1;159(5):2241-2252

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory