Dio2 MGI Mouse Gene Detail - MGI:1338833 - deiodinase, iodothyronine, type II

Symbol

Dio2
Name

deiodinase, iodothyronine, type II

Feature Type

protein coding gene
IDs

MGI:1338833
NCBI Gene: 13371
Gene Overview

MyGene.info: DIO2
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:90724552-90738438 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 44.05 cM
Mapping Data

2 experiments

SNPs within 2kb

133 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338833	protein coding gene	Chr12:90724552-90739038 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019996	protein coding gene	Chr12:91854121-91868018 (-)
A/J	MGP_AJ_G0019951	protein coding gene	Chr12:88406809-88420702 (-)
AKR/J	MGP_AKRJ_G0019927	protein coding gene	Chr12:90759270-90773154 (-)
BALB/cJ	MGP_BALBcJ_G0019937	protein coding gene	Chr12:88696584-88710468 (-)
C3H/HeJ	MGP_C3HHeJ_G0019739	protein coding gene	Chr12:91398954-91412847 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020386	protein coding gene	Chr12:94556955-94570839 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018000	protein coding gene	Chr12:85900865-85914643 (-)
CAST/EiJ	MGP_CASTEiJ_G0019286	protein coding gene	Chr12:86312380-86326294 (-)
CBA/J	MGP_CBAJ_G0019711	protein coding gene	Chr12:98121531-98135460 (-)
DBA/2J	MGP_DBA2J_G0019822	protein coding gene	Chr12:87883534-87897427 (-)
FVB/NJ	MGP_FVBNJ_G0019811	protein coding gene	Chr12:86763103-86777032 (-)
LP/J	MGP_LPJ_G0019898	protein coding gene	Chr12:91662453-91676382 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019852	protein coding gene	Chr12:100884495-100898430 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020415	protein coding gene	Chr12:90394977-90408906 (-)
PWK/PhJ	MGP_PWKPhJ_G0019049	protein coding gene	Chr12:82476053-82490038 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018845	protein coding gene	Chr12:84550980-84564875 (-)
WSB/EiJ	MGP_WSBEiJ_G0019339	protein coding gene	Chr12:91121817-91135746 (-)

Human Ortholog

DIO2, iodothyronine deiodinase 2

Vertebrate Orthologs

10

Human Ortholog

DIO2, iodothyronine deiodinase 2
Orthology source: HomoloGene, HGNC
Synonyms

5DII, D2, DIOII, SelY, TXDI2
Links

HGNC:2884

NCBI Gene ID: 1734

neXtProt AC: NX_Q92813

UniProt: Q92813
Chr Location

14q31.1; chr14:80197525-80231054 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 621
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DIO2
Protein SuperFamily

iodothyronine deiodinase
Gene Tree

Dio2

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Phenotype Summary

13 phenotypes from 2 alleles in 3 genetic backgrounds
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

5
Genomic Mutations

1 involving Dio2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display elevated thyroxine (T4) and thyroid-stimulating hormone levels, changes in the metabolism and excretion of iodothyronines, and impaired adaptive thermogenesis.

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All GO Annotations

22
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

122
cDNA Data

12
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dio2

ZFIN dio2

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Dio2 interacts with 426 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

45
RefSeq

2
UniProt

2
CCDS

CCDS36514.1

Ensembl

ENSMUSG00000007682 (Evidence)
NCBI Gene

13371

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007682	Ensembl Gene Model \| MGI Sequence Detail	13887	C57BL/6J	± kb
transcript	ENSMUST00000082432	Ensembl \| MGI Sequence Detail	5815	Not Applicable
polypeptide	ENSMUSP00000081013	Ensembl \| MGI Sequence Detail	266	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006481 type II iodothyronine deiodinase

(term hierarchy)
EC

1.21.99.4
InterPro Domains

IPR000643 Iodothyronine deiodinase

IPR008261 Iodothyronine deiodinase, active site

IPR036249 Thioredoxin-like superfamily

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All nucleic 20

cDNA 14

Primer pair 5

Other 1

Microarray probesets 5

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MGI:2144791

Summaries

All 102

Developmental Gene Expression 20

Gene Ontology 9

Phenotypes 50
Earliest

J:52912 Davey JC, et al., Cloning of a 5.8 kb cDNA for a mouse type 2 deiodinase. Endocrinology. 1999 Feb;140(2):1022-5
Latest

J:292219 Ferdous A, et al., FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth. Nat Commun. 2020 May 21;11(1):2551

TSS for Dio2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117191	Chr12:90738562-90738568 (-)	-127 bp
Tssr117190	Chr12:90738095-90738157 (-)	312 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/13/2020 MGI 6.16