Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHRS4,DHRS4L1,DHRS4L2
  • Mouse genes Dhrs4
  • Rat genes Dhrs4
  • Zfish genes dhrs4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhrs4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000253	3-keto sterol reductase activity	DHRS4	IDA		Human	PMID:18571493
Molecular Function	GO:0000253	3-keto sterol reductase activity	DHRS4	IDA		Human	PMID:19056333
Molecular Function	GO:0000253	3-keto sterol reductase activity	DHRS4	IDA		Human	PMID:23128527
Molecular Function	GO:0018455	alcohol dehydrogenase [NAD(P)+] activity	DHRS4	IDA		Human	PMID:18571493
Molecular Function	GO:0004090	carbonyl reductase (NADPH) activity	DHRS4	IDA		Human	PMID:18571493
Molecular Function	GO:0004090	carbonyl reductase (NADPH) activity	DHRS4	IDA		Human	PMID:19056333
Molecular Function	GO:0004090	carbonyl reductase (NADPH) activity	DHRS4	IDA		Human	PMID:23128527
Molecular Function	GO:0042802	identical protein binding	DHRS4	IDA		Human	PMID:18571493
Molecular Function	GO:0042802	identical protein binding	DHRS4	IPI	UniProtKB:Q9BTZ2	Human	PMID:18571493
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	DHRS4	IDA		Human	PMID:19442656
Molecular Function	GO:0001758	retinal dehydrogenase activity	Dhrs4	IDA		Mouse	PMID:12680773
Cellular Component	GO:0005739	mitochondrion	Dhrs4	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005778	peroxisomal membrane	DHRS4	IDA		Human	PMID:10333503
Cellular Component	GO:0005777	peroxisome	DHRS4	IDA		Human	PMID:17230527
Cellular Component	GO:0005777	peroxisome	Dhrs4	IDA		Mouse	PMID:12680773
Cellular Component	GO:0005777	peroxisome	Dhrs4	IDA		Rat	PMID:10333503|RGD:70713
Biological Process	GO:0006066	alcohol metabolic process	DHRS4	IDA		Human	PMID:18571493
Biological Process	GO:0042180	cellular ketone metabolic process	DHRS4	IDA		Human	PMID:18571493
Biological Process	GO:0042180	cellular ketone metabolic process	DHRS4	IDA		Human	PMID:19056333
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	DHRS4	IDA		Human	PMID:19442656
Biological Process	GO:0042574	retinal metabolic process	Dhrs4	IDA		Mouse	PMID:12680773
Biological Process	GO:0008202	steroid metabolic process	DHRS4	IDA		Human	PMID:18571493
Biological Process	GO:0008202	steroid metabolic process	DHRS4	IDA		Human	PMID:19056333

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern