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Dhrs4
Gene Detail
Symbol

Name
ID
Dhrs4
dehydrogenase/reductase (SDR family) member 4
MGI:90169
Synonyms
D14Ucla2, RRD
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:55478758-55490338 bp, + strand
From Ensembl annotation of GRCm38

  11581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DHRS4
Gene Tree: Dhrs4

Human
homologs
DHRS4, dehydrogenase/reductase (SDR family) member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10901
neXtProt AC: NX_Q9BTZ2

Human Synonyms: CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR25C1, SDR25C2, SDR-SRL

Human Chr (Location): 14q11.2; chr14:23953735-23969279 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
 
Homozygous mutant mice exhibit a decreased mean serum IgG2a response to ovalbumin challenge when compared with that of controls. Female mutants exhibit an increased depressive-like response during tail suspension testing.
 
Interactions
Dhrs4 interacts with 43 markers (Mir15a, Mir29a, Mir103-1, ...)
Expression
cDNA source data(97)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dhrs4    NEW 
Molecular
reagents
All nucleic(98) cDNA(97) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022210 (Evidence)
Entrez Gene 28200 (Evidence)
UniGene 27427
DFCI TC1576627, TC1589470
DoTS DT.101260319, DT.493260, DT.55100191
NIA Mouse Gene Index U015652
EC 1.1.1.184
Consensus CDS Project CCDS27111.1
International Mouse Phenotyping Consortium Status Dhrs4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022210 Ensembl Gene Model | MGI Sequence Detail 11581 C57BL/6J ±  kb
transcript ENSMUST00000022821 Ensembl | MGI Sequence Detail 1390 Not Applicable 
polypeptide ENSMUSP00000022821 Ensembl | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(11 from dbSNP Build 137)    SNPs within 2kb including multiple locations(13)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000006466 dehydrogenase/reductase SDR family member 4
References
(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(38)
Other
accession IDs
MGD-MRK-3967, MGI:2145595, MGI:2145693

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory