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Dhrs4 Gene Detail
Summary
  • Symbol
    Dhrs4
  • Name
    dehydrogenase/reductase (SDR family) member 4
  • Synonyms
    D14Ucla2, RRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:90169
    NCBI Gene: 28200
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55716215-55727797 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_90169
protein coding gene Chr14:55715880-55727797 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021343
protein coding gene Chr14:49506961-49518293 (+)
A/J MGP_AJ_G0021302
protein coding gene Chr14:48522439-48535632 (+)
AKR/J MGP_AKRJ_G0021278
protein coding gene Chr14:50271592-50282392 (+)
BALB/cJ MGP_BALBcJ_G0021306
protein coding gene Chr14:48469865-48480958 (+)
C3H/HeJ MGP_C3HHeJ_G0021086
protein coding gene Chr14:49954408-49966931 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021744
protein coding gene Chr14:51995327-52010180 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019291
protein coding gene Chr14:46902112-46912432 (+)
CAST/EiJ MGP_CASTEiJ_G0020605
protein coding gene Chr14:46215123-46226970 (+)
CBA/J MGP_CBAJ_G0021053
protein coding gene Chr14:53555344-53569112 (+)
DBA/2J MGP_DBA2J_G0021174
protein coding gene Chr14:48244183-48255798 (+)
FVB/NJ MGP_FVBNJ_G0021156
protein coding gene Chr14:47700629-47711035 (+)
LP/J MGP_LPJ_G0021248
protein coding gene Chr14:50546902-50558961 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021180
protein coding gene Chr14:52919684-52931191 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021771
protein coding gene Chr14:49451974-49465821 (+)
PWK/PhJ MGP_PWKPhJ_G0020352
protein coding gene Chr14:44778688-44790761 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020180
protein coding gene Chr14:45446478-45456588 (+)
WSB/EiJ MGP_WSBEiJ_G0020658
protein coding gene Chr14:49736878-49747327 (+)



Homology
more
  • Human Ortholog
    DHRS4, dehydrogenase/reductase 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHRS4, dehydrogenase/reductase 4
  • Synonyms
    CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR25C1, SDR25C2, SDR-SRL
  • Links
    NCBI Gene ID: 10901
    neXtProt AC: NX_Q9BTZ2
    UniProt: Q9BTZ2

  • Chr Location
    14q11.2; chr14:23953735-23969279 (+)  GRCh38.p7

  • Human Ortholog
    DHRS4L1, dehydrogenase/reductase 4 like 1 (pseudogene)
  • Synonyms
    SDR25C4
  • Links
    NCBI Gene ID: 728635
    UniProt: P0CG22

  • Chr Location
    14q11.2; chr14:24007009-24051377 (+)  GRCh38.p7

  • Human Ortholog
    DHRS4L2, dehydrogenase/reductase 4 like 2
  • Synonyms
    SDR25C3
  • Links
    NCBI Gene ID: 317749
    UniProt: Q6PKH6

  • Chr Location
    14q11.2; chr14:23969874-24006408 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Dhrs4
  • Find Mice (IMSR)
Homozygous mutant mice exhibit a decreased mean serum IgG2a response to ovalbumin challenge when compared with that of controls. Female mutants exhibit an increased depressive-like response during tail suspension testing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022210 Ensembl Gene Model | MGI Sequence Detail 11583 C57BL/6J ±  kb
transcript ENSMUST00000022821 Ensembl | MGI Sequence Detail 1392 Not Applicable  
polypeptide ENSMUSP00000022821 Ensembl | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 99
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-3967, MGI:2145595, MGI:2145693
References
more
  • Summaries
    All 43
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory