Dhrs4
Gene Detail

Symbol Name ID

Dhrs4 dehydrogenase/reductase (SDR family) member 4 MGI:90169

Synonyms

D14Ucla2, RRD

Feature Type

protein coding gene

Genetic Map

Chromosome 14

28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr14:55478758-55490338 bp, + strand From Ensembl annotation of GRCm38   11581 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49646  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dhrs4

Human homologs

Human Homolog		DHRS4, dehydrogenase/reductase (SDR family) member 4
NCBI Gene ID		10901
neXtProt AC		NX_Q9BTZ2
Human Synonyms		CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR25C1, SDR25C2, SDR-SRL
Human Chr (Location)		14q11.2; chr14:24422965-24438488 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous mutant mice exhibit a decreased mean serum IgG2a response to ovalbumin challenge when compared with that of controls. Female mutants exhibit an increased depressive-like response during tail suspension testing.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	alcohol metabolic process, cellular ketone metabolic process, ...
Component	mitochondrion, nucleus, ...
Function	3-keto sterol reductase activity, alcohol dehydrogenase [NAD(P)+] activity, ...

Expression

cDNA source data(97)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) cDNA(97) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022210 (Evidence)
Entrez Gene	28200 (Evidence)
UniGene	27427
DFCI	TC1576627, TC1589470
DoTS	DT.101260319, DT.493260, DT.55100191
NIA Mouse Gene Index	U015652
EC	1.1.1.184
Consensus CDS Project	CCDS27111.1
International Mouse Knockout Project Status	Dhrs4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022210	Ensembl Gene Model | MGI Sequence Detail	11581	C57BL/6J
transcript	ENSMUST00000022821	Ensembl | MGI Sequence Detail	1390	Not Applicable
polypeptide	ENSMUSP00000022821	Ensembl | MGI Sequence Detail	279	Not Applicable

All sequences(33) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027052	Dehydrogenase/reductase SDR member 2/4
InterPro	IPR002347	Glucose/ribitol dehydrogenase
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR020904	Short-chain dehydrogenase/reductase, conserved site
InterPro	IPR002198	Short-chain dehydrogenase/reductase SDR
Protein Ontology	PR:000006466	dehydrogenase/reductase SDR family member 4

References

(Earliest) J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(39)

Other accession IDs

MGD-MRK-3967, MGI:2145595, MGI:2145693