Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DHH
  • Mouse genes Dhh
  • Rat genes Dhh
  • Zfish genes dhh
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Dhh

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	DHH	IDA		Human	PMID:19561611
Molecular Function	GO:0005113	patched binding	DHH	IDA		Human	PMID:11472839
Molecular Function	GO:0005113	patched binding	Dhh	IPI	UniProtKB:Q13635|UniProtKB:Q9Y6C5	Mouse	MGI:MGI:1313055|PMID:9811851
Molecular Function	GO:0005515	protein binding	DHH	IPI	UniProtKB:Q96QV1	Human	PMID:19561611
Molecular Function	GO:0005515	protein binding	DHH	IPI	UniProtKB:Q96QV1-1	Human	PMID:19561611
Molecular Function	GO:0005515	protein binding	DHH	IPI	UniProtKB:Q4KMG0	Human	PMID:20519495
Molecular Function	GO:0005515	protein binding	DHH	IPI	UniProtKB:Q9BWV1	Human	PMID:20519495
Molecular Function	GO:0005515	protein binding	Dhh	IPI	PR:Q7TN16	Mouse	PMID:10050855
Molecular Function	GO:0008270	zinc ion binding	DHH	IDA		Human	PMID:19561611
Biological Process	GO:0033327	Leydig cell differentiation	Dhh	IGI	MGI:MGI:1095403	Mouse	PMID:17495005
Biological Process	GO:0033327	Leydig cell differentiation	Dhh	IMP	MGI:MGI:1934259	Mouse	PMID:12050120
Biological Process	GO:0008584	male gonad development	Dhh	IMP		Mouse	MGI:MGI:1927432|PMID:11090455
Biological Process	GO:0008584	male gonad development	Dhh	IMP		Mouse	MGI:MGI:1346102|PMID:8805249
Biological Process	GO:0030238	male sex determination	Dhh	IGI	MGI:MGI:1095403	Mouse	PMID:17495005
Biological Process	GO:0042552	myelination	Dhh	IEP		Rat	PMID:11746771|RGD:1302240
Biological Process	GO:0001649	osteoblast differentiation	Dhh	IDA		Mouse	PMID:25639508
Biological Process	GO:0038001	paracrine signaling	Dhh	IMP		Mouse	MGI:MGI:6438280|PMID:32151560
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	DHH	IDA		Human	PMID:24342078
Biological Process	GO:0050810	regulation of steroid biosynthetic process	Dhh	IGI	MGI:MGI:1095403	Mouse	PMID:17495005
Biological Process	GO:0032355	response to estradiol	Dhh	IEP		Rat	PMID:17109907|RGD:1601055
Biological Process	GO:0043627	response to estrogen	Dhh	IEP		Rat	PMID:17109907|RGD:1601055
Biological Process	GO:0014044	Schwann cell development	Dhh	IMP		Mouse	MGI:MGI:1344238|PMID:10482238
Biological Process	GO:0007224	smoothened signaling pathway	Dhh	IDA		Mouse	PMID:25639508
Biological Process	GO:0007286	spermatid development	Dhh	IMP	MGI:MGI:1934259	Mouse	PMID:17495005
Biological Process	GO:0007286	spermatid development	Dhh	IEP		Rat	PMID:21893610|RGD:150573809
Biological Process	GO:0007283	spermatogenesis	Dhh	IMP		Mouse	MGI:MGI:1346102|PMID:8805249

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern