Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes DEPDC5
  • Mouse genes Depdc5
  • Rat genes Depdc5
  • Zfish genes depdc5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Depdc5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	DEPDC5	IDA		Human	PMID:23723238
Molecular Function	GO:0044877	protein-containing complex binding	DEPDC5	IDA		Human	PMID:23723238
Cellular Component	GO:0005829	cytosol	Depdc5	IDA		Mouse	MGI:MGI:5494184|PMID:23542697
Cellular Component	GO:1990130	GATOR1 complex	DEPDC5	IPI		Human	PMID:25263562
Cellular Component	GO:1990130	GATOR1 complex	DEPDC5	IDA		Human	PMID:23723238
Cellular Component	GO:0005765	lysosomal membrane	DEPDC5	HDA		Human	PMID:17897319
Cellular Component	GO:0005765	lysosomal membrane	DEPDC5	IDA		Human	PMID:28199306
Cellular Component	GO:0005764	lysosome	DEPDC5	IDA		Human	PMID:23723238
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Depdc5	IDA		Mouse	MGI:MGI:5494184|PMID:23542697
Biological Process	GO:0034198	cellular response to amino acid starvation	DEPDC5	IMP		Human	PMID:23723238
Biological Process	GO:0032007	negative regulation of TOR signaling	DEPDC5	IMP		Human	PMID:23723238
Biological Process	GO:1904262	negative regulation of TORC1 signaling	DEPDC5	IMP		Human	PMID:25457612
Biological Process	GO:1904262	negative regulation of TORC1 signaling	DEPDC5	IMP		Human	PMID:29769719
Biological Process	GO:0098908	regulation of neuronal action potential	depdc5	IMP	ZFIN:ZDB-MRPHLNO-180920-8	Zfish	PMID:29761115
Biological Process	GO:0098908	regulation of neuronal action potential	depdc5	IMP	ZFIN:ZDB-MRPHLNO-180920-9	Zfish	PMID:29761115
Biological Process	GO:0036269	swimming behavior	depdc5	IMP	ZFIN:ZDB-MRPHLNO-180920-8	Zfish	PMID:29761115
Biological Process	GO:0036269	swimming behavior	depdc5	IMP	ZFIN:ZDB-MRPHLNO-180920-9	Zfish	PMID:29761115

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern