Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CYB5R4
  • Mouse genes Cyb5r4
  • Rat genes Cyb5r4
  • Zfish genes cyb5r4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cyb5r4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	CYB5R4	IDA		Human	PMID:10611283
Molecular Function	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	Cyb5r4	IDA		Mouse	PMID:15131110
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	Cyb5r4	IDA		Rat	PMID:11913972|RGD:632262
Molecular Function	GO:0020037	heme binding	Cyb5r4	IDA		Rat	PMID:11913972|RGD:632262
Molecular Function	GO:0016174	NAD(P)H oxidase H2O2-forming activity	CYB5R4	IDA		Human	PMID:10611283
Molecular Function	GO:0003958	NADPH-hemoprotein reductase activity	Cyb5r4	IDA		Rat	PMID:11913972|RGD:632262
Molecular Function	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	CYB5R4	IDA		Human	PMID:15131110
Molecular Function	GO:0005515	protein binding	Cyb5r4	IPI	PR:P62748	Mouse	PMID:14739275
Molecular Function	GO:0005515	protein binding	Cyb5r4	IPI	PR:P84075	Mouse	PMID:14739275
Cellular Component	GO:0005783	endoplasmic reticulum	CYB5R4	IDA		Human	PMID:15131110
Cellular Component	GO:0005783	endoplasmic reticulum	Cyb5r4	IDA		Mouse	PMID:15131110
Cellular Component	GO:0048471	perinuclear region of cytoplasm	CYB5R4	IDA		Human	PMID:10611283
Biological Process	GO:0048468	cell development	Cyb5r4	IMP	MGI:MGI:3050973	Mouse	PMID:15247412
Biological Process	GO:0006091	generation of precursor metabolites and energy	CYB5R4	IDA		Human	PMID:10611283
Biological Process	GO:0042593	glucose homeostasis	Cyb5r4	IMP	MGI:MGI:3050973	Mouse	PMID:15247412
Biological Process	GO:0030073	insulin secretion	Cyb5r4	IMP	MGI:MGI:3050973	Mouse	PMID:15247412
Biological Process	GO:0006739	NADP metabolic process	Cyb5r4	IDA		Rat	PMID:11913972|RGD:632262
Biological Process	GO:0072593	reactive oxygen species metabolic process	CYB5R4	IDA		Human	PMID:15131110
Biological Process	GO:0046677	response to antibiotic	Cyb5r4	IMP	MGI:MGI:3050973	Mouse	PMID:17343567
Biological Process	GO:0006801	superoxide metabolic process	CYB5R4	IDA		Human	PMID:10611283

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern