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Cyb5r4 Gene Detail
Summary
  • Symbol
    Cyb5r4
  • Name
    cytochrome b5 reductase 4
  • Synonyms
    2810034J18Rik, b5/b5r, B5+B5R, Ncb5or
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386848
    NCBI Gene: 266690
  • Gene Overview
    MyGene.info: CYB5R4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:87022014-87077774 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55761 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 46.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CYB5R4, cytochrome b5 reductase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYB5R4, cytochrome b5 reductase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    cb5/cb5R, dJ676J13.1, NCB5OR
  • Links
    NCBI Gene ID: 51167
    neXtProt AC: NX_Q7L1T6
    UniProt: Q7L1T6

  • Chr Location
    6q14.2; chr6:83859651-83960427 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69207
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CYB5R4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Cyb5r4 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit defects in glucose homeostasis and pancreatic abnormalities consistent with symptoms of diabetes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037524 VEGA Gene Model | MGI Sequence Detail 55761 C57BL/6J ±  kb
    transcript OTTMUST00000096730 VEGA | MGI Sequence Detail 2644 Not Applicable  
    polypeptide OTTMUSP00000054073 VEGA | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      527 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914464, MGI:2143407
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:59088 Zhu H, et al., Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14742-7
    • Latest
      J:180337 Wang W, et al., Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells. Biochim Biophys Acta. 2011 Nov;1812(11):1532-41

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory