Cyb5r4
Gene Detail

Symbol Name ID

Cyb5r4 cytochrome b5 reductase 4 MGI:2386848

Synonyms

2810034J18Rik, b5/b5r, B5+B5R, Ncb5or

Feature Type

protein coding gene

Genetic Map

Chromosome 9

46.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:87022014-87077774 bp, + strand From VEGA annotation of GRCm38   55761 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cyb5r4

Human homologs

Human Homolog		CYB5R4, cytochrome b5 reductase 4
NCBI Gene ID		51167
neXtProt AC		NX_Q7L1T6
Human Synonyms		cb5/cb5R, dJ676J13.1, NCB5OR, RP4-676J13.1
Human Chr (Location)		6pter-q22.33; chr6:84569370-84670146 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(5) Gene trapped(3)
 

Homozygous null mice exhibit defects in glucose homeostasis and pancreatic abnormalities consistent with symptoms of diabetes.

 
Human Diseases Modeled Using Mouse Cyb5r4 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	cell development, generation of precursor metabolites and energy, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	cytochrome-b5 reductase activity, acting on NAD(P)H, flavin adenine dinucleotide binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (74)    Tissues (11)    Images (22)
Theiler Stages: 23

Assay Type	Results
RNA in situ	74

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000037524 (Evidence)
Ensembl Gene Model	ENSMUSG00000032872 (Evidence)
Entrez Gene	266690 (Evidence)
DFCI	TC1575429, TC1589655, TC1639201, TC1688248, TC1695074
DoTS	DT.101179042, DT.101735357, DT.102531989, DT.110613368, DT.110808518, DT.490357
NIA Mouse Gene Index	U010828, U050624
EC	1.6.2.2
Consensus CDS Project	CCDS40716.2
International Mouse Knockout Project Status	Cyb5r4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037524	VEGA Gene Model | MGI Sequence Detail	55761	C57BL/6J
transcript	OTTMUST00000096730	VEGA | MGI Sequence Detail	2644	Not Applicable
polypeptide	OTTMUSP00000054073	VEGA | MGI Sequence Detail	528	Not Applicable

All sequences(72) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(241 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017447	CS domain
InterPro	IPR007052	CS-like domain
InterPro	IPR001199	Cytochrome b5
InterPro	IPR018506	Cytochrome b5, heme-binding site
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR008978	HSP20-like chaperone
InterPro	IPR001834	NADH:cytochrome b5 reductase (CBR)
InterPro	IPR008333	Oxidoreductase, FAD-binding domain
InterPro	IPR001433	Oxidoreductase FAD/NAD(P)-binding
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000006083	cytochrome b5 reductase 4

References

(Earliest) J:59088 Zhu H, et al., Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14742-7
(Latest) J:180337 Wang W, et al., Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells. Biochim Biophys Acta. 2011 Nov;1812(11):1532-41
All references(43)

Other accession IDs

MGI:1914464, MGI:2143407