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Cyb5r4
Gene Detail
Symbol

Name
ID
Cyb5r4
cytochrome b5 reductase 4
MGI:2386848
Synonyms
2810034J18Rik, b5/b5r, B5+B5R, Ncb5or
Feature Type
protein coding gene
Genetic Map
Chromosome 9
46.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:87022014-87077774 bp, + strand
From VEGA annotation of GRCm38

  55761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69207  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CYB5R4
Gene Tree: Cyb5r4

Human
homologs
CYB5R4, cytochrome b5 reductase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51167
neXtProt AC: NX_Q7L1T6

Human Synonyms: cb5/cb5R, dJ676J13.1, NCB5OR

Human Chr (Location): 6pter-q22.33; chr6:83859651-83960427 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice exhibit defects in glucose homeostasis and pancreatic abnormalities consistent with symptoms of diabetes.
 
Human Diseases Modeled in Mice Using Cyb5r4 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Cyb5r4 interacts with 229 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (74)    Tissues (11)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 74
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cyb5r4    NEW 
Molecular
reagents
All nucleic(52) cDNA(52)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037524 (Evidence)
Ensembl Gene Model ENSMUSG00000032872 (Evidence)
Entrez Gene 266690 (Evidence)
UniGene 30166
DFCI TC1639201, TC1688248, TC1589655, TC1575429, TC1695074
DoTS DT.101179042, DT.110808518, DT.101735357, DT.490357, DT.102531989, DT.110613368
NIA Mouse Gene Index U050624, U010828
EC 1.6.2.2
Consensus CDS Project CCDS40716.2
International Mouse Phenotyping Consortium Status Cyb5r4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037524 VEGA Gene Model | MGI Sequence Detail 55761 C57BL/6J ±  kb
transcript OTTMUST00000096730 VEGA | MGI Sequence Detail 2644 Not Applicable 
polypeptide OTTMUSP00000054073 VEGA | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(538 from dbSNP Build 137)    SNPs within 2kb including multiple locations(542)
Protein-related
information
ResourceIDDescription
InterPro IPR007052 CS-like domain
InterPro IPR018506 Cytochrome b5, heme-binding site
InterPro IPR001199 Cytochrome b5-like heme/steroid binding domain
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR008978 HSP20-like chaperone
InterPro IPR001834 NADH:cytochrome b5 reductase (CBR)
InterPro IPR008333 Oxidoreductase, FAD-binding domain
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000006083 cytochrome b5 reductase 4
References
(Earliest) J:59088 Zhu H, et al., Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14742-7
(Latest) J:180337 Wang W, et al., Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells. Biochim Biophys Acta. 2011 Nov;1812(11):1532-41
All references(42)
Disease annotation references (2)
Other
accession IDs
MGI:1914464, MGI:2143407

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory