Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CTC1
  • Mouse genes Ctc1
  • Rat genes Ctc1
  • Zfish genes ctc1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ctc1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	CTC1	IDA		Human	PMID:22763445
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q86WV5	Human	PMID:19854130
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q9H668	Human	PMID:19854130
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q96AP0	Human	PMID:22763445
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q9H668	Human	PMID:22763445
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q9NUX5	Human	PMID:22763445
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q92624	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q86WV5	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	CTC1	IPI	UniProtKB:Q9H668	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	Ctc1	IPI	UniProtKB:Q8K2X3	Mouse	MGI:MGI:4441245|PMID:19119139
Molecular Function	GO:0003697	single-stranded DNA binding	Ctc1	IDA		Mouse	MGI:MGI:4441245|PMID:19119139
Molecular Function	GO:0042162	telomeric DNA binding	CTC1	IDA		Human	PMID:19854130
Cellular Component	GO:0000781	chromosome, telomeric region	CTC1	IDA		Human	PMID:19854130
Cellular Component	GO:0000781	chromosome, telomeric region	Ctc1	IDA		Mouse	MGI:MGI:4441108|PMID:19854130
Cellular Component	GO:1990879	CST complex	CTC1	IDA		Human	PMID:19854130
Cellular Component	GO:1990879	CST complex	CTC1	IDA		Human	PMID:22763445
Cellular Component	GO:1990879	CST complex	Ctc1	IDA		Mouse	MGI:MGI:4441108|PMID:19854130
Cellular Component	GO:0005829	cytosol	CTC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CTC1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	CTC1	IDA		Human	PMID:19854130
Cellular Component	GO:0005634	nucleus	Ctc1	IDA		Mouse	MGI:MGI:4441108|PMID:19854130
Cellular Component	GO:0005634	nucleus	Ctc1	IDA		Mouse	MGI:MGI:4441245|PMID:19119139
Biological Process	GO:0048539	bone marrow development	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0051276	chromosome organization	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0006974	DNA damage response	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0071425	hematopoietic stem cell proliferation	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0035264	multicellular organism growth	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	CTC1	IDA		Human	PMID:22763445
Biological Process	GO:0045740	positive regulation of DNA replication	Ctc1	IDA		Mouse	MGI:MGI:4441245|PMID:19119139
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0090399	replicative senescence	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0048536	spleen development	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0000723	telomere maintenance	CTC1	IMP		Human	PMID:19854131
Biological Process	GO:0010833	telomere maintenance via telomere lengthening	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781
Biological Process	GO:0048538	thymus development	Ctc1	IMP	MGI:MGI:5427642	Mouse	PMID:22531781

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern