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Ctc1 Gene Detail
Summary
  • Symbol
    Ctc1
  • Name
    CTS telomere maintenance complex component 1
  • Synonyms
    1500010J02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916214
    NCBI Gene: 68964
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68906737-68927299 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.29 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916214
protein coding gene Chr11:68906014-68927299 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018513
protein coding gene Chr11:69413956-69435574 (+)
A/J MGP_AJ_G0018482
protein coding gene Chr11:66805648-66826930 (+)
AKR/J MGP_AKRJ_G0018451
protein coding gene Chr11:68802314-68825234 (+)
BALB/cJ MGP_BALBcJ_G0018453
protein coding gene Chr11:67128291-67148810 (+)
C3H/HeJ MGP_C3HHeJ_G0018266
protein coding gene Chr11:68824228-68846056 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018905
protein coding gene Chr11:71523086-71550854 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016549
protein coding gene Chr11:63744992-63766933 (+)
CAST/EiJ MGP_CASTEiJ_G0017822
protein coding gene Chr11:69059927-69080401 (+)
CBA/J MGP_CBAJ_G0018240
protein coding gene Chr11:74715931-74756562 (+)
DBA/2J MGP_DBA2J_G0018349
protein coding gene Chr11:66406569-66427121 (+)
FVB/NJ MGP_FVBNJ_G0018339
protein coding gene Chr11:66022903-66043957 (+)
LP/J MGP_LPJ_G0018420
protein coding gene Chr11:70000909-70022294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018362
protein coding gene Chr11:75367825-75388885 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018946
protein coding gene Chr11:69053282-69073741 (+)
PWK/PhJ MGP_PWKPhJ_G0017597
protein coding gene Chr11:67039470-67060794 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017385
protein coding gene Chr11:68884385-68906013 (+)
WSB/EiJ MGP_WSBEiJ_G0017875
protein coding gene Chr11:68693777-68717023 (+)



Homology
more
  • Human Ortholog
    CTC1, CST telomere replication complex component 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTC1, CST telomere replication complex component 1
  • Synonyms
    AAF132, AAF-132, C17orf68, CRMCC, tmp494178
  • Links
    NCBI Gene ID: 80169
    neXtProt AC: NX_Q2NKJ3
    UniProt: Q2NKJ3

  • Chr Location
    17p13.1; chr17:8224815-8248058 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit defective telomere replication that leads to stem cell exhaustion, bone marrow failure and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020898 Ensembl Gene Model | MGI Sequence Detail 20563 C57BL/6J ±  kb
    transcript ENSMUST00000116359 Ensembl | MGI Sequence Detail 3978 Not Applicable  
    polypeptide ENSMUSP00000112063 Ensembl | MGI Sequence Detail 1212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 8
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:184809 Gu P, et al., CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012 May 16;31(10):2309-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory