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Ctc1
Gene Detail
 Symbol
Name
ID
Ctc1
CTS telomere maintenance complex component 1
MGI:1916214
Synonyms 1500010J02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.29 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:69015911-69036473 bp, + strand
From VEGA annotation of GRCm38

  20563 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ctc1

Human
homologs
Human Homolog CTC1, CTS telomere maintenance complex component 1
NCBI Gene ID 80169
neXtProt AC  NX_Q2NKJ3
Human Synonyms  AAF132, AAF-132, C17orf68, CRMCC, tmp494178
Human Chr (Location)  17p13.1; chr17:8224821-8248095 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTC1
Mutations,
alleles, and
phenotypes
All mutations/alleles(74) : Gene trapped(70) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted allele exhibit defective telomere replication that leads to stem cell exhaustion, bone marrow failure and premature death.
 
Interactions
Ctc1 interacts with 378 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process aging, bone marrow development, ...
Component chromosome, chromosome, telomeric region, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (7)    Images (2)
Theiler Stages: 17, 28
Assay TypeResults
RNA in situ 7
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000005957 (Evidence)
Ensembl Gene ModelENSMUSG00000020898 (Evidence)
Entrez Gene68964 (Evidence)
DFCITC1572362, TC1647260, TC1653628, TC1686780, TC1689058
DoTSDT.103568126, DT.97355938, DT.99845319
NIA Mouse Gene IndexU012803
Consensus CDS ProjectCCDS36189.2, CCDS48824.1, CCDS70214.1
International Mouse Knockout Project StatusCtc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005957 VEGA Gene Model | MGI Sequence Detail 20563 C57BL/6J ±  kb
transcript OTTMUST00000086895 VEGA | MGI Sequence Detail 3978 Not Applicable 
polypeptide OTTMUSP00000047102 VEGA | MGI Sequence Detail 1212 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(22) UniProt(3)
Polymorphisms SNPs within 2kb(178 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031091 CST complex subunit CTC1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184809 Gu P, et al., CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012 May 16;31(10):2309-21
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory