Ctc1
Gene Detail

Symbol Name ID

Ctc1 CTS telomere maintenance complex component 1 MGI:1916214

Synonyms

1500010J02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.29 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:69015911-69036473 bp, + strand From VEGA annotation of GRCm38   20563 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11830  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ctc1

Human homologs

Human Homolog		CTC1, CTS telomere maintenance complex component 1
NCBI Gene ID		80169
neXtProt AC		NX_Q2NKJ3
Human Synonyms		AAF132, AAF-132, C17orf68, CRMCC, tmp494178
Human Chr (Location)		17p13.1; chr17:8128139-8151413 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CTC1

Alleles and phenotypes

All alleles(74) : Targeted(4) Gene trapped(70)
 

Mice homozygous for a targeted allele exhibit defective telomere replication that leads to stem cell exhaustion, bone marrow failure and premature death.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	aging, bone marrow development, ...
Component	chromosome, chromosome, telomeric region, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (6)    Images (1)
Theiler Stages: 17

Assay Type	Results
RNA in situ	6

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(12)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000005957 (Evidence)
Ensembl Gene Model	ENSMUSG00000020898 (Evidence)
Entrez Gene	68964 (Evidence)
DFCI	TC1572362, TC1647260, TC1653628, TC1686780, TC1689058
DoTS	DT.103568126, DT.97355938, DT.99845319
NIA Mouse Gene Index	U012803
Consensus CDS Project	CCDS36189.2, CCDS48824.1
International Mouse Knockout Project Status	Ctc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005957	VEGA Gene Model | MGI Sequence Detail	20563	C57BL/6J
transcript	OTTMUST00000086895	VEGA | MGI Sequence Detail	3978	Not Applicable
polypeptide	OTTMUSP00000047102	VEGA | MGI Sequence Detail	1212	Not Applicable

All sequences(103) RefSeq(5) UniProt(3)

Polymorphisms

SNPs(123 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000031091	CST complex subunit CTC1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184809 Gu P, et al., CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 2012 May 16;31(10):2309-21
All references(35)