Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CRTAM
  • Mouse genes Crtam
  • Rat genes Crtam
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Crtam

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Crtam	IPI	UniProtKB:Q80U72	Mouse	MGI:MGI:3834299|PMID:18329370
Molecular Function	GO:0005102	signaling receptor binding	CRTAM	IPI	UniProtKB:Q9BY67	Human	PMID:15811952
Molecular Function	GO:0005102	signaling receptor binding	Crtam	IPI	UniProtKB:Q8R5M8	Mouse	MGI:MGI:3689781|PMID:15811952
Cellular Component	GO:0001772	immunological synapse	Crtam	IDA		Mouse	MGI:MGI:3834299|PMID:18329370
Cellular Component	GO:0005886	plasma membrane	CRTAM	IDA		Human	PMID:15811952
Cellular Component	GO:0005886	plasma membrane	Crtam	IDA		Mouse	MGI:MGI:5581366|PMID:24687959
Cellular Component	GO:0005886	plasma membrane	Crtam	IDA		Mouse	MGI:MGI:3689781|PMID:15811952
Cellular Component	GO:0005886	plasma membrane	Crtam	IDA		Mouse	MGI:MGI:4359960|PMID:19752223
Cellular Component	GO:0005886	plasma membrane	Crtam	IDA		Mouse	MGI:MGI:3834299|PMID:18329370
Biological Process	GO:0008037	cell recognition	CRTAM	IDA		Human	PMID:15811952
Biological Process	GO:0008037	cell recognition	Crtam	IDA		Mouse	MGI:MGI:3689781|PMID:15811952
Biological Process	GO:0051606	detection of stimulus	CRTAM	IDA		Human	PMID:15811952
Biological Process	GO:0051606	detection of stimulus	Crtam	IDA		Mouse	MGI:MGI:3689781|PMID:15811952
Biological Process	GO:0002355	detection of tumor cell	CRTAM	IDA		Human	PMID:15811952
Biological Process	GO:0002355	detection of tumor cell	Crtam	IDA		Mouse	MGI:MGI:3689781|PMID:15811952
Biological Process	GO:0001768	establishment of T cell polarity	Crtam	IDA		Mouse	MGI:MGI:3834299|PMID:18329370
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	Crtam	IMP		Mouse	MGI:MGI:4359960|PMID:19752223
Biological Process	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	Crtam	IMP		Mouse	MGI:MGI:5581366|PMID:24687959
Biological Process	GO:0097021	lymphocyte migration into lymphoid organs	Crtam	IMP		Mouse	MGI:MGI:5581366|PMID:24687959
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	Crtam	IMP		Mouse	MGI:MGI:3834299|PMID:18329370
Biological Process	GO:0001819	positive regulation of cytokine production	CRTAM	IDA		Human	PMID:15811952
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	CRTAM	IDA		Human	PMID:15811952
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Crtam	IDA		Mouse	MGI:MGI:3689781|PMID:15811952
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	CRTAM	IDA		Human	PMID:15811952
Biological Process	GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	Crtam	IDA		Mouse	MGI:MGI:3689781|PMID:15811952
Biological Process	GO:0032729	positive regulation of type II interferon production	Crtam	IMP		Mouse	MGI:MGI:3834299|PMID:18329370
Biological Process	GO:2001185	regulation of CD8-positive, alpha-beta T cell activation	Crtam	IMP		Mouse	MGI:MGI:4359960|PMID:19752223
Biological Process	GO:0050863	regulation of T cell activation	Crtam	IMP		Mouse	MGI:MGI:5581366|PMID:24687959
Biological Process	GO:0045580	regulation of T cell differentiation	Crtam	IMP		Mouse	MGI:MGI:5581366|PMID:24687959

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern