Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLEC6A
  • Mouse genes Clec4n
  • Rat genes Clec6a-ps1
  • Zfish genes lectin,si:ch211-125e6.12,si:ch211-125e6.13
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clec4n

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	CLEC6A	IDA		Human	PMID:28652405
Molecular Function	GO:0030246	carbohydrate binding	CLEC6A	IDA		Human	PMID:28652405
Molecular Function	GO:0030246	carbohydrate binding	Clec4n	IDA		Mouse	MGI:MGI:4454937|PMID:20493731
Molecular Function	GO:0005537	mannose binding	CLEC6A	IDA		Human	PMID:23911656
Molecular Function	GO:0005537	mannose binding	CLEC6A	IDA		Human	PMID:28652405
Molecular Function	GO:0038187	pattern recognition receptor activity	CLEC6A	IDA		Human	PMID:23911656
Molecular Function	GO:0038187	pattern recognition receptor activity	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900
Molecular Function	GO:0005515	protein binding	CLEC6A	IPI	UniProtKB:Q8WXI8	Human	PMID:23911656
Molecular Function	GO:0005515	protein binding	Clec4n	IPI	UniProtKB:P20491	Mouse	MGI:MGI:4887333|PMID:17050534
Cellular Component	GO:0005886	plasma membrane	CLEC6A	IDA		Human	PMID:23911656
Biological Process	GO:0061760	antifungal innate immune response	Clec4n	IMP		Mouse	MGI:MGI:6445005|PMID:32358020
Biological Process	GO:0061760	antifungal innate immune response	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900
Biological Process	GO:0050832	defense response to fungus	Clec4n	IDA		Mouse	MGI:MGI:4454937|PMID:20493731
Biological Process	GO:0001879	detection of yeast	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900
Biological Process	GO:0045087	innate immune response	Clec4n	IDA		Mouse	MGI:MGI:4887333|PMID:17050534
Biological Process	GO:0001819	positive regulation of cytokine production	Clec4n	IDA		Mouse	MGI:MGI:4454937|PMID:20493731
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Clec4n	IDA		Mouse	MGI:MGI:4887333|PMID:17050534
Biological Process	GO:1902533	positive regulation of intracellular signal transduction	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900
Biological Process	GO:2000318	positive regulation of T-helper 17 type immune response	Clec4n	IMP		Mouse	MGI:MGI:6445005|PMID:32358020
Biological Process	GO:0001878	response to yeast	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900
Biological Process	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Clec4n	IMP		Mouse	MGI:MGI:5300086|PMID:22041900

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern