Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CLCF1
  • Mouse genes Clcf1
  • Rat genes Clcf1
  • Zfish genes clcf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Clcf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	CLCF1	IDA		Human	PMID:10966616
Molecular Function	GO:0005127	ciliary neurotrophic factor receptor binding	CLCF1	IDA		Human	PMID:11285233
Molecular Function	GO:0005125	cytokine activity	CLCF1	IDA		Human	PMID:10966616
Molecular Function	GO:0005125	cytokine activity	Clcf1	IDA		Mouse	PMID:10500198
Molecular Function	GO:0005515	protein binding	CLCF1	IPI	UniProtKB:O75462	Human	PMID:10966616
Molecular Function	GO:0005515	protein binding	CLCF1	IPI	UniProtKB:P02649	Human	PMID:29507344
Molecular Function	GO:0005515	protein binding	Clcf1	IPI	UniProtKB:Q99497	Mouse	MGI:MGI:5574296|PMID:21097510
Molecular Function	GO:0005515	protein binding	Clcf1	IPI	UniProtKB:P08226	Mouse	MGI:MGI:6162766|PMID:29507344
Molecular Function	GO:0005102	signaling receptor binding	CLCF1	IPI	UniProtKB:O75462	Human	PMID:15272019
Molecular Function	GO:0005102	signaling receptor binding	CLCF1	IPI	UniProtKB:P26992	Human	PMID:15272019
Cellular Component	GO:0097059	CNTFR-CLCF1 complex	CLCF1	IDA		Human	PMID:11285233
Cellular Component	GO:0097058	CRLF-CLCF1 complex	CLCF1	IDA		Human	PMID:10966616
Cellular Component	GO:0005576	extracellular region	CLCF1	IDA		Human	PMID:10966616
Biological Process	GO:0030183	B cell differentiation	Clcf1	IDA		Mouse	PMID:10500198
Biological Process	GO:0007166	cell surface receptor signaling pathway	Clcf1	IDA		Mouse	PMID:10500198
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	CLCF1	IDA		Human	PMID:10966616
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	CLCF1	IDA		Human	PMID:11285233
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	Clcf1	IDA		Mouse	MGI:MGI:5009184|PMID:12090754
Biological Process	GO:0048680	positive regulation of axon regeneration	clcf1	IMP	ZFIN:ZDB-MRPHLNO-140620-4	Zfish	PMID:24523552
Biological Process	GO:0030890	positive regulation of B cell proliferation	Clcf1	IDA		Mouse	MGI:MGI:3777853|PMID:12023368
Biological Process	GO:0008284	positive regulation of cell population proliferation	CLCF1	IDA		Human	PMID:10966616
Biological Process	GO:0008284	positive regulation of cell population proliferation	CLCF1	IDA		Human	PMID:11285233
Biological Process	GO:0002639	positive regulation of immunoglobulin production	Clcf1	IDA		Mouse	MGI:MGI:3777853|PMID:12023368
Biological Process	GO:0048295	positive regulation of isotype switching to IgE isotypes	Clcf1	IDA		Mouse	MGI:MGI:3777853|PMID:12023368
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CLCF1	IDA		Human	PMID:10966616
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	CLCF1	IDA		Human	PMID:11285233
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	Clcf1	IDA		Mouse	MGI:MGI:5009184|PMID:12090754
Biological Process	GO:0007259	receptor signaling pathway via JAK-STAT	Clcf1	IDA		Mouse	PMID:10500198
Biological Process	GO:0007165	signal transduction	Clcf1	IDA		Mouse	MGI:MGI:1346205|PMID:10500198

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern