About   Help   FAQ
Clcf1 Gene Detail
Summary
  • Symbol
    Clcf1
  • Name
    cardiotrophin-like cytokine factor 1
  • Synonyms
    Bsf3, CLC, NNT-1/BSF-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930088
    NCBI Gene: 56708
Location & Maps
more
Homology
more
  • Human Ortholog
    CLCF1, cardiotrophin-like cytokine factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLCF1, cardiotrophin-like cytokine factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BSF3, BSF-3, CISS2, CLC, NNT1, NNT-1, NR6
  • Links
    NCBI Gene ID: 23529
    neXtProt AC: NX_Q9UBD9

  • Chr Location
    11q13.3; chr11:67364168-67374177 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CLCF1 associations

Human Disease Mouse Models
       Cold-Induced Sweating Syndrome 2; CISS2   OMIM: 610313
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with a failure to suckle and decreased facial and spinal motor neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028319 VEGA Gene Model | MGI Sequence Detail 9253 C57BL/6J ±  kb
transcript OTTMUST00000070190 VEGA | MGI Sequence Detail 1847 Not Applicable  
polypeptide OTTMUSP00000035741 VEGA | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    8 from dbSNP Build 137
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005527 cardiotrophin-like cytokine factor 1
  • InterPro Domains
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
    IPR010681 Plethodontid receptivity factor PRF
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 39
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 9
  • Earliest
    J:57927 Senaldi G, et al., Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11458-63
  • Latest
    J:211242 McNally RS, et al., DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem. 2011 Feb 11;286(6):4098-106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory