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Clcf1 Gene Detail
Summary
  • Symbol
    Clcf1
  • Name
    cardiotrophin-like cytokine factor 1
  • Synonyms
    Bsf3, CLC, NNT-1/BSF-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930088
    NCBI Gene: 56708
  • Gene Overview
    MyGene.info: CLCF1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4214238-4223490 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.91 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930088
protein coding gene Chr19:4214238-4223505 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024657
protein coding gene Chr19:1058549-1067800 (+)
A/J MGP_AJ_G0024623
protein coding gene Chr19:1016804-1026067 (+)
AKR/J MGP_AKRJ_G0024596
protein coding gene Chr19:1045145-1054399 (+)
BALB/cJ MGP_BALBcJ_G0024623
protein coding gene Chr19:1007290-1016564 (+)
C3H/HeJ MGP_C3HHeJ_G0024391
protein coding gene Chr19:1041880-1051163 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025071
protein coding gene Chr19:1095417-1104681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022500
protein coding gene Chr19:959466-969583 (+)
CAST/EiJ MGP_CASTEiJ_G0023863
protein coding gene Chr19:1055638-1064938 (+)
CBA/J MGP_CBAJ_G0024362
protein coding gene Chr19:1159196-1168469 (+)
DBA/2J MGP_DBA2J_G0024490
protein coding gene Chr19:977100-986352 (+)
FVB/NJ MGP_FVBNJ_G0024457
protein coding gene Chr19:986566-995804 (+)
LP/J MGP_LPJ_G0024576
protein coding gene Chr19:1051730-1060981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024487
protein coding gene Chr19:1099810-1109060 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025118
protein coding gene Chr19:1042556-1051810 (+)
PWK/PhJ MGP_PWKPhJ_G0023609
protein coding gene Chr19:1030416-1039766 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023414
protein coding gene Chr19:1023868-1033825 (+)
WSB/EiJ MGP_WSBEiJ_G0023925
protein coding gene Chr19:1030316-1040926 (+)



Homology
more
  • Human Ortholog
    CLCF1, cardiotrophin like cytokine factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLCF1, cardiotrophin like cytokine factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BSF3, BSF-3, CISS2, CLC, NNT1, NNT-1, NR6
  • Links
    NCBI Gene ID: 23529
    neXtProt AC: NX_Q9UBD9
    UniProt: Q9UBD9

  • Chr Location
    11q13.2; chr11:67364168-67374177 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CLCF1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with a failure to suckle and decreased facial and spinal motor neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040663 Ensembl Gene Model | MGI Sequence Detail 9253 C57BL/6J ±  kb
    transcript ENSMUST00000046506 Ensembl | MGI Sequence Detail 1847 Not Applicable  
    polypeptide ENSMUSP00000045562 Ensembl | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:57927 Senaldi G, et al., Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11458-63
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory