About   Help   FAQ
Clcf1
Gene Detail
 Symbol
Name
ID
Clcf1
cardiotrophin-like cytokine factor 1
MGI:1930088
Synonyms Bsf3, CLC, NNT-1/BSF-3
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.91 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:4214238-4223490 bp, + strand
From VEGA annotation of GRCm38

  9253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Clcf1

Human
homologs
Human Homolog CLCF1, cardiotrophin-like cytokine factor 1
NCBI Gene ID 23529
neXtProt AC  NX_Q9UBD9
Human Synonyms  BSF3, BSF-3, CISS2, CLC, NNT1, NNT-1, NR6
Human Chr (Location)  11q13.3; chr11:67364168-67374177 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CLCF1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with a failure to suckle and decreased facial and spinal motor neurons.
 
Interactions
Clcf1 interacts with 245 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process B cell differentiation, cell surface receptor signaling pathway, ...
Component CNTFR-CLCF1 complex, CRLF-CLCF1 complex, ...
Function ciliary neurotrophic factor receptor binding, cytokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (33)    Images (13)
Theiler Stages: 10, 18, 22, 23, 24, 25, 26
Assay TypeResults
RNA in situ 15
RT-PCR 21
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000028319 (Evidence)
Ensembl Gene ModelENSMUSG00000040663 (Evidence)
Entrez Gene56708 (Evidence)
UniGene347919
DFCITC1588333, TC1642068
DoTSDT.60104747, DT.94360696, DT.94360699
NIA Mouse Gene IndexU038747
Consensus CDS ProjectCCDS29423.1
International Mouse Knockout Project StatusClcf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028319 VEGA Gene Model | MGI Sequence Detail 9253 C57BL/6J ±  kb
transcript OTTMUST00000070190 VEGA | MGI Sequence Detail 1847 Not Applicable 
polypeptide OTTMUSP00000035741 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR010681 Plethodontid receptivity factor PRF
Protein Ontology PR:000005527 cardiotrophin-like cytokine factor 1
References (Earliest) J:57927 Senaldi G, et al., Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11458-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory