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Clcf1
Gene Detail
Symbol

Name
ID
Clcf1
cardiotrophin-like cytokine factor 1
MGI:1930088
Synonyms
Bsf3, CLC, NNT-1/BSF-3
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.91 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:4214238-4223490 bp, + strand
From VEGA annotation of GRCm38

  9253 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLCF1
Gene Tree: Clcf1

Human
homologs
CLCF1, cardiotrophin-like cytokine factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23529
neXtProt AC: NX_Q9UBD9

Human Synonyms: BSF3, BSF-3, CISS2, CLC, NNT1, NNT-1, NR6

Human Chr (Location): 11q13.3; chr11:67364168-67374177 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CLCF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality associated with a failure to suckle and decreased facial and spinal motor neurons.
 
Interactions
Clcf1 interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (33)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 15
RT-PCR 21
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase clcf1 ; ZFIN clcf1    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000028319 (Evidence)
Ensembl Gene Model ENSMUSG00000040663 (Evidence)
Entrez Gene 56708 (Evidence)
UniGene 347919
DFCI TC1588333, TC1642068
DoTS DT.94360699, DT.94360696, DT.60104747
NIA Mouse Gene Index U038747
Consensus CDS Project CCDS29423.1
International Mouse Phenotyping Consortium Status Clcf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028319 VEGA Gene Model | MGI Sequence Detail 9253 C57BL/6J ±  kb
transcript OTTMUST00000070190 VEGA | MGI Sequence Detail 1847 Not Applicable 
polypeptide OTTMUSP00000035741 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR010681 Plethodontid receptivity factor PRF
Protein Ontology PR:000005527 cardiotrophin-like cytokine factor 1
References
(Earliest) J:57927 Senaldi G, et al., Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11458-63
(Latest) J:211242 McNally RS, et al., DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J Biol Chem. 2011 Feb 11;286(6):4098-106
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory