Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRNA6
  • Mouse genes Chrna6
  • Rat genes Chrna6
  • Zfish genes chrna6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna6	IMP	MGI:MGI:2179133	Mouse	PMID:11850448
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna6	IDA		Rat	PMID:22550286|RGD:8549526
Molecular Function	GO:0005515	protein binding	CHRNA6	IPI	UniProtKB:Q86Y78	Human	PMID:27344019
Molecular Function	GO:0005515	protein binding	Chrna6	IPI	PR:Q9ERK7	Mouse	PMID:12944511
Molecular Function	GO:0005515	protein binding	Chrna6	IPI	PR:O70174	Mouse	PMID:12944511
Cellular Component	GO:0005892	acetylcholine-gated channel complex	Chrna6	IDA		Mouse	PMID:12944511
Cellular Component	GO:0098691	dopaminergic synapse	Chrna6	IDA		Mouse	PMID:12944511
Cellular Component	GO:0098691	dopaminergic synapse	Chrna6	IMP		Mouse	PMID:12944511
Cellular Component	GO:0016020	membrane	Chrna6	IDA		Rat	PMID:16129735|RGD:2303195
Cellular Component	GO:0045211	postsynaptic membrane	Chrna6	IDA		Mouse	PMID:24607281
Cellular Component	GO:0045211	postsynaptic membrane	Chrna6	IEP		Mouse	PMID:24607281
Cellular Component	GO:0045211	postsynaptic membrane	Chrna6	IDA		Rat	PMID:24607281|RGD:13702281
Cellular Component	GO:0098793	presynapse	Chrna6	IDA		Mouse	MGI:MGI:2673776|PMID:12944511
Cellular Component	GO:0042734	presynaptic membrane	Chrna6	IDA		Mouse	PMID:24607281
Cellular Component	GO:0042734	presynaptic membrane	Chrna6	IEP		Mouse	PMID:24607281
Cellular Component	GO:0042734	presynaptic membrane	Chrna6	IDA		Rat	PMID:24607281|RGD:13702281
Cellular Component	GO:0032991	protein-containing complex	Chrna6	IDA		Rat	PMID:16129735|RGD:2303195
Biological Process	GO:0051899	membrane depolarization	Chrna6	IMP	MGI:MGI:2179133	Mouse	PMID:12944511
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna6	IMP		Mouse	PMID:12944511
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Chrna6	IDA		Mouse	PMID:12944511
Biological Process	GO:0014059	regulation of dopamine secretion	Chrna6	IMP	MGI:MGI:2179133	Mouse	PMID:12944511

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern