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Chrna6 Gene Detail
Summary
  • Symbol
    Chrna6
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 6
  • Synonyms
    Acra6, alpha6 nAChR
  • Feature Type
    protein coding gene
  • IDs
    MGI:106213
    NCBI Gene: 11440
  • Gene Overview
    MyGene.info: CHRNA6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:27403212-27413944 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10733 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 16.02 cM, cytoband A3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CHRNA6, cholinergic receptor nicotinic alpha 6 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRNA6, cholinergic receptor nicotinic alpha 6 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHNRA6
  • Links
    NCBI Gene ID: 8973
    neXtProt AC: NX_Q15825
    UniProt: Q15825

  • Chr Location
    8p11.21; chr8:42752620-42768786 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20888
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHRNA6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homzygous mutant animals have decreased numbers of high affinity binding sites for [3H]nicotine, [3H]epibaditine, and [3H]cytisine in the terminal region of the retinal ganglion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061079 VEGA Gene Model | MGI Sequence Detail 10733 C57BL/6J ±  kb
    transcript OTTMUST00000149209 VEGA | MGI Sequence Detail 2906 Not Applicable  
    polypeptide OTTMUSP00000077444 VEGA | MGI Sequence Detail 494 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      128 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005459 neuronal acetylcholine receptor subunit alpha-6
    • InterPro Domains
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    Molecular
    Reagents
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    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33905
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:31397 Drescher DG, et al., Analysis of nicotinic acetylcholine receptor subunits in the cochlea of the mouse. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995 Nov;112(3):267-73
    • Latest
      J:234076 Wieskopf JS, et al., The nicotinic alpha6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Sci Transl Med. 2015 May 13;7(287):287ra72

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory