Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CHRNA2
  • Mouse genes Chrna2
  • Rat genes Chrna2
  • Zfish genes chrna2a,chrna2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Chrna2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015464	acetylcholine receptor activity	CHRNA2	IDA		Human	PMID:8906617
Molecular Function	GO:0015464	acetylcholine receptor activity	chrna2a	IDA		Zfish	PMID:22580045
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	CHRNA2	IDA		Human	PMID:8906617
Molecular Function	GO:0022848	acetylcholine-gated monoatomic cation-selective channel activity	Chrna2	IDA		Rat	PMID:2832952|RGD:728252
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna2	IPI	CHEBI:4803	Rat	PMID:16129735|RGD:2303195
Molecular Function	GO:1901363	heterocyclic compound binding	Chrna2	IDA		Rat	PMID:15016836|RGD:2303194
Molecular Function	GO:0050997	quaternary ammonium group binding	Chrna2	IDA		Rat	PMID:15016836|RGD:2303194
Cellular Component	GO:0005892	acetylcholine-gated channel complex	CHRNA2	IDA		Human	PMID:8906617
Cellular Component	GO:0005892	acetylcholine-gated channel complex	chrna2a	IDA		Zfish	PMID:22580045
Cellular Component	GO:0071944	cell periphery	Chrna2	IDA		Mouse	PMID:21884692
Cellular Component	GO:0045171	intercellular bridge	CHRNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	Chrna2	IDA		Rat	PMID:16129735|RGD:2303195
Cellular Component	GO:0120111	neuron projection cytoplasm	Chrna2	IDA		Rat	PMID:19385992|RGD:152995360
Cellular Component	GO:0005654	nucleoplasm	CHRNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CHRNA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	Chrna2	IDA		Rat	PMID:16129735|RGD:2303195
Biological Process	GO:0035095	behavioral response to nicotine	chrna2a	IMP	ZFIN:ZDB-MRPHLNO-180118-6	Zfish	PMID:24738729
Biological Process	GO:0071316	cellular response to nicotine	Chrna2	IDA		Rat	PMID:19385992|RGD:152995360
Biological Process	GO:0098828	modulation of inhibitory postsynaptic potential	Chrna2	IDA		Rat	PMID:19385992|RGD:152995360
Biological Process	GO:1905144	response to acetylcholine	Chrna2	IDA		Rat	PMID:15016836|RGD:2303194
Biological Process	GO:0035094	response to nicotine	chrna2a	IMP	ZFIN:ZDB-MRPHLNO-180118-6	Zfish	PMID:24738729
Biological Process	GO:0007165	signal transduction	CHRNA2	IDA		Human	PMID:8906617

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern