Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CFL2
  • Mouse genes Cfl2
  • Rat genes Cfl2
  • Zfish genes cfl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cfl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Cfl2	IDA		Mouse	MGI:MGI:5784994|PMID:11809832
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P60709	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P63261	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P60709	Human	PMID:21516116
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P50461	Human	PMID:24860983
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P60709	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P63261	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P60709	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P60709	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P60981	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P61019	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P63261	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:P78317	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:Q08426	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:Q7KZS0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:Q9C029	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:Q9NUX5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:Q14204	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	CFL2	IPI	UniProtKB:Q92876	Human	PMID:32814053
Cellular Component	GO:0070062	extracellular exosome	CFL2	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	CFL2	HDA		Human	PMID:23580065
Cellular Component	GO:0031674	I band	CFL2	IDA		Human	PMID:17160903
Cellular Component	GO:0030018	Z disc	CFL2	IDA		Human	PMID:19752190
Biological Process	GO:0030042	actin filament depolymerization	CFL2	IDA		Human	PMID:19752190
Biological Process	GO:0030042	actin filament depolymerization	Cfl2	IDA		Mouse	MGI:MGI:5784994|PMID:11809832
Biological Process	GO:0030042	actin filament depolymerization	Cfl2	IDA		Mouse	PMID:24840128
Biological Process	GO:0030042	actin filament depolymerization	Cfl2	IGI	MGI:MGI:1337100	Mouse	PMID:24840128
Biological Process	GO:0030043	actin filament fragmentation	Cfl2	IDA		Mouse	MGI:MGI:5784994|PMID:11809832
Biological Process	GO:0007015	actin filament organization	Cfl2	IMP	MGI:MGI:2182095,MGI:MGI:5316051,MGI:MGI:5316057	Mouse	PMID:22343409
Biological Process	GO:0046716	muscle cell cellular homeostasis	Cfl2	IMP	MGI:MGI:2182095,MGI:MGI:5316051,MGI:MGI:5316057	Mouse	PMID:22343409
Biological Process	GO:0030836	positive regulation of actin filament depolymerization	CFL2	IMP		Human	PMID:17160903
Biological Process	GO:0045214	sarcomere organization	Cfl2	IMP	MGI:MGI:2182095,MGI:MGI:5316051,MGI:MGI:5316057	Mouse	PMID:22343409
Biological Process	GO:0007519	skeletal muscle tissue development	Cfl2	IMP		Mouse	MGI:MGI:5784971|PMID:24598388

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern