Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CD274
  • Mouse genes Cd274
  • Rat genes Cd274
  • Zfish genes si:ch211-241b2.5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Cd274

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:P33681	Human	PMID:18585785
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:P33681	Human	PMID:20587542
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:Q15116	Human	PMID:20587542
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:P33681	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:Q15116	Human	PMID:21982860
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:P33681	Human	PMID:23417675
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:Q15116	Human	PMID:23417675
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:Q8IZR5	Human	PMID:28813410
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:Q9NX76	Human	PMID:28813410
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:Q9NX76	Human	PMID:28813417
Molecular Function	GO:0005515	protein binding	CD274	IPI	UniProtKB:P33681	Human	PMID:31000591
Molecular Function	GO:0005515	protein binding	Cd274	IPI	UniProtKB:Q00609|UniProtKB:Q02242	Mouse	MGI:MGI:5315328|PMID:21884581
Molecular Function	GO:0005515	protein binding	Cd274	IPI	UniProtKB:Q02242	Mouse	MGI:MGI:3807128|PMID:18641123
Molecular Function	GO:0005515	protein binding	Cd274	IPI	UniProtKB:Q00609|UniProtKB:Q02242	Mouse	MGI:MGI:6189321|PMID:23417675
Molecular Function	GO:0005515	protein binding	Cd274	IPI	UniProtKB:Q00609	Mouse	MGI:MGI:6315984|PMID:31000591
Molecular Function	GO:0005515	protein binding	Cd274	IPI	PR:Q02242	Mouse	PMID:15568026
Cellular Component	GO:0015629	actin cytoskeleton	CD274	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	Cd274	IDA		Rat	PMID:21717117|RGD:9589064
Cellular Component	GO:0031901	early endosome membrane	CD274	IDA		Human	PMID:28813417
Cellular Component	GO:0009897	external side of plasma membrane	Cd274	IDA		Mouse	PMID:15568026
Cellular Component	GO:0070062	extracellular exosome	CD274	IDA		Human	PMID:17076679
Cellular Component	GO:0005654	nucleoplasm	CD274	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD274	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CD274	IDA		Human	PMID:28813410
Cellular Component	GO:0005886	plasma membrane	CD274	IDA		Human	PMID:28813417
Cellular Component	GO:0055038	recycling endosome membrane	CD274	IDA		Human	PMID:28813417
Biological Process	GO:0007166	cell surface receptor signaling pathway	CD274	IDA		Human	PMID:10581077
Biological Process	GO:0006955	immune response	CD274	IDA		Human	PMID:10581077
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	CD274	IMP		Human	PMID:12538684
Biological Process	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation	CD274	IDA		Human	PMID:24691993
Biological Process	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	CD274	IMP		Human	PMID:28813410
Biological Process	GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	CD274	IMP		Human	PMID:28813417
Biological Process	GO:0032693	negative regulation of interleukin-10 production	CD274	IMP		Human	PMID:12538684
Biological Process	GO:0032693	negative regulation of interleukin-10 production	CD274	IMP		Human	PMID:24187568
Biological Process	GO:0042130	negative regulation of T cell proliferation	Cd274	IDA		Mouse	PMID:17016562
Biological Process	GO:1903556	negative regulation of tumor necrosis factor superfamily cytokine production	CD274	IMP		Human	PMID:24187568
Biological Process	GO:0032689	negative regulation of type II interferon production	CD274	IMP		Human	PMID:12538684
Biological Process	GO:0032689	negative regulation of type II interferon production	CD274	IMP		Human	PMID:24187568
Biological Process	GO:1905404	positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process	CD274	IDA		Human	PMID:24187568
Biological Process	GO:0030335	positive regulation of cell migration	Cd274	IMP		Rat	PMID:21717117|RGD:9589064
Biological Process	GO:0032733	positive regulation of interleukin-10 production	CD274	IDA		Human	PMID:10581077
Biological Process	GO:0042102	positive regulation of T cell proliferation	Cd274	IMP		Rat	PMID:21717117|RGD:9589064
Biological Process	GO:0002845	positive regulation of tolerance induction to tumor cell	CD274	IMP		Human	PMID:28813410
Biological Process	GO:0002845	positive regulation of tolerance induction to tumor cell	CD274	IMP		Human	PMID:28813417
Biological Process	GO:0034097	response to cytokine	CD274	IDA		Human	PMID:17489864
Biological Process	GO:0007165	signal transduction	CD274	IDA		Human	PMID:10581077
Biological Process	GO:0031295	T cell costimulation	CD274	IDA		Human	PMID:10581077
Biological Process	GO:1901998	toxin transport	Cd274	IMP		Mouse	PMID:23716698

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern