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Cd274
Gene Detail
Symbol

Name
ID
Cd274
CD274 antigen
MGI:1926446
Synonyms
B7-H1, Pdcd1lg1, PD-L1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
23.88 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:29367455-29388095 bp, + strand
From VEGA annotation of GRCm38

  20641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CD274
Protein SuperFamily: programmed cell death 1 ligand
Gene Tree: Cd274

Human
homologs
CD274, CD274 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29126
neXtProt AC: NX_Q9NZQ7

Human Synonyms: B7-H, B7H1, PDCD1L1, PDCD1LG1, PDL1, PD-L1

Human Chr (Location): 9p24; chr9:5450381-5470567 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(8) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit altered susceptibility to experimental autoimmune encephalomyelitis, induced arthritis, nerve injury, autoimmune diabetes, bacterial infection, viral infection, and parasitic infection due to abnormal T cell morphology and physiology.
 
Interactions
Cd274 interacts with 312 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell surface receptor signaling pathway, immune response, ...
Component cell surface, external side of plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 4
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000014904 (Evidence)
Ensembl Gene Model ENSMUSG00000016496 (Evidence)
Entrez Gene 60533 (Evidence)
UniGene 245363
DFCI TC1600647, TC1638363
DoTS DT.486866
NIA Mouse Gene Index U019348
Consensus CDS Project CCDS29735.1
International Mouse Phenotyping Consortium Status Cd274
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014904 VEGA Gene Model | MGI Sequence Detail 20641 C57BL/6J ±  kb
transcript OTTMUST00000035406 VEGA | MGI Sequence Detail 3622 Not Applicable 
polypeptide OTTMUSP00000015826 VEGA | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set domain
Protein Ontology PR:000001543 programmed cell death 1 ligand 1
References
(Earliest) J:64991 Freeman GJ, et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000 Oct 2;192(7):1027-34
(Latest) J:222944 Liu J, et al., Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6682-7
All references(137)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory