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Cd274
Gene Detail
 Symbol
Name
ID
Cd274
CD274 antigen
MGI:1926446
Synonyms B7-H1, Pdcd1lg1, PD-L1
Feature Type protein coding gene
Genetic Map
Chromosome 19
23.88 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:29367455-29388095 bp, + strand
From VEGA annotation of GRCm38

  20641 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8560  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: programmed cell death 1 ligand
Gene Tree: Cd274

Human
homologs
Human Homolog CD274, CD274 molecule
NCBI Gene ID 29126
neXtProt AC  NX_Q9NZQ7
Human Synonyms  B7-H, B7H1, PDCD1L1, PDCD1LG1, PDL1, PD-L1
Human Chr (Location)  9p24; chr9:5450399-5470567 (+)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit altered susceptibility to experimental autoimmune encephalomyelitis, induced arthritis, nerve injury, autoimmune diabetes, bacterial infection, viral infection, and parasitic infection due to abnormal T cell morphology and physiology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell surface receptor signaling pathway, immune response, ...
Component external side of plasma membrane, extracellular vesicular exosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (2)   
Theiler Stages: 19, 20
Assay TypeResults
RNA in situ 2
RT-PCR 4
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014904 (Evidence)
Ensembl Gene ModelENSMUSG00000016496 (Evidence)
Entrez Gene60533 (Evidence)
UniGene245363
DFCITC1600647, TC1638363
DoTSDT.486866
NIA Mouse Gene IndexU019348
Consensus CDS ProjectCCDS29735.1
International Mouse Knockout Project StatusCd274
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014904 VEGA Gene Model | MGI Sequence Detail 20641 C57BL/6J ±  kb
transcript OTTMUST00000035406 VEGA | MGI Sequence Detail 3622 Not Applicable 
polypeptide OTTMUSP00000015826 VEGA | MGI Sequence Detail 290 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001543 programmed cell death 1 ligand 1
References (Earliest) J:64991 Freeman GJ, et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000 Oct 2;192(7):1027-34
(Latest) J:210599 Xu C, et al., Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014 May 12;25(5):590-604
All references(132)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory