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Cd274 Gene Detail
Summary
  • Symbol
    Cd274
  • Name
    CD274 antigen
  • Synonyms
    B7-H1, Pdcd1lg1, PD-L1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926446
    NCBI Gene: 60533
  • Gene Overview
    MyGene.info: CD274
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29367455-29388095 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 23.88 cM, cytoband C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926446
protein coding gene Chr19:29367438-29388095 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025022
protein coding gene Chr19:27821779-27846578 (+)
A/J MGP_AJ_G0024999
protein coding gene Chr19:26420253-26441355 (+)
AKR/J MGP_AKRJ_G0024967
protein coding gene Chr19:27378703-27400807 (+)
BALB/cJ MGP_BALBcJ_G0024998
protein coding gene Chr19:26469693-26490495 (+)
C3H/HeJ MGP_C3HHeJ_G0024754
protein coding gene Chr19:27355110-27377246 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025439
protein coding gene Chr19:28595293-28617586 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022858
protein coding gene Chr19:26391525-26411837 (+)
CAST/EiJ MGP_CASTEiJ_G0024224
protein coding gene Chr19:27183986-27220273 (+)
CBA/J MGP_CBAJ_G0024732
protein coding gene Chr19:29943620-29966583 (+)
DBA/2J MGP_DBA2J_G0024864
protein coding gene Chr19:26378127-26399100 (+)
FVB/NJ MGP_FVBNJ_G0024826
protein coding gene Chr19:26235082-26255903 (+)
LP/J MGP_LPJ_G0024949
protein coding gene Chr19:27824697-27846606 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024853
protein coding gene Chr19:29885016-29908371 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025494
protein coding gene Chr19:27396928-27419353 (+)
PWK/PhJ MGP_PWKPhJ_G0023972
protein coding gene Chr19:26051593-26073656 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023776
protein coding gene Chr19:26671792-26694642 (+)
WSB/EiJ MGP_WSBEiJ_G0024291
protein coding gene Chr19:27445681-27470745 (+)



Homology
more
  • Human Ortholog
    CD274, CD274 molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CD274, CD274 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B7-H, B7H1, PDCD1L1, PDCD1LG1, PDL1, PD-L1
  • Links
    NCBI Gene ID: 29126
    neXtProt AC: NX_Q9NZQ7
    UniProt: Q9NZQ7

  • Chr Location
    9p24.1; chr9:5450503-5470567 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 5 alleles in 9 genetic backgrounds
    7 phenotypes from multigenic genotypes
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered susceptibility to experimental autoimmune encephalomyelitis, induced arthritis, nerve injury, autoimmune diabetes, bacterial infection, viral infection, and parasitic infection due to abnormal T cellmorphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016496 Ensembl Gene Model | MGI Sequence Detail 20641 C57BL/6J ±  kb
    transcript ENSMUST00000016640 Ensembl | MGI Sequence Detail 3622 Not Applicable  
    polypeptide ENSMUSP00000016640 Ensembl | MGI Sequence Detail 290 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 17
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 88
    • Earliest
      J:64991 Freeman GJ, et al., Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000 Oct 2;192(7):1027-34
    • Latest
      J:265288 Chen G, et al., Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. 2018 Aug;560(7718):382-386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory