Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CCR6
  • Mouse genes Ccr6
  • Rat genes Ccr6
  • Zfish genes ccr6a,ccr6b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ccr6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019957	C-C chemokine binding	CCR6	IMP		Human	PMID:12081481
Molecular Function	GO:0019957	C-C chemokine binding	CCR6	IDA		Human	PMID:20068036
Molecular Function	GO:0019957	C-C chemokine binding	Ccr6	IDA		Mouse	MGI:MGI:5784982|PMID:20068036
Molecular Function	GO:0016493	C-C chemokine receptor activity	CCR6	IMP		Human	PMID:12081481
Molecular Function	GO:0016493	C-C chemokine receptor activity	CCR6	IDA		Human	PMID:20068036
Molecular Function	GO:0016493	C-C chemokine receptor activity	Ccr6	IDA		Mouse	MGI:MGI:5784982|PMID:20068036
Molecular Function	GO:0005515	protein binding	CCR6	IPI	UniProtKB:O15263	Human	PMID:20068036
Molecular Function	GO:0005515	protein binding	CCR6	IPI	UniProtKB:P60022	Human	PMID:25122636
Molecular Function	GO:0005515	protein binding	Ccr6	IPI	UniProtKB:O15263|UniProtKB:P82019	Mouse	MGI:MGI:5784982|PMID:20068036
Molecular Function	GO:0005515	protein binding	Ccr6	IPI	PR:O89093	Mouse	PMID:9862452
Cellular Component	GO:0009986	cell surface	CCR6	IDA		Human	PMID:12081481
Cellular Component	GO:0009986	cell surface	Ccr6	IDA		Mouse	PMID:23620790
Cellular Component	GO:0009897	external side of plasma membrane	Ccr6	IDA		Mouse	PMID:23034280
Cellular Component	GO:0036126	sperm flagellum	CCR6	IDA		Human	PMID:23765988
Cellular Component	GO:0036126	sperm flagellum	Ccr6	IDA		Mouse	MGI:MGI:5784973|PMID:23765988
Cellular Component	GO:0097225	sperm midpiece	CCR6	IDA		Human	PMID:23765988
Cellular Component	GO:0097524	sperm plasma membrane	CCR6	IDA		Human	PMID:23765988
Cellular Component	GO:0097524	sperm plasma membrane	Ccr6	IDA		Mouse	MGI:MGI:5784973|PMID:23765988
Cellular Component	GO:0097228	sperm principal piece	CCR6	IDA		Human	PMID:23765988
Cellular Component	GO:0097228	sperm principal piece	Ccr6	IDA		Mouse	MGI:MGI:5784973|PMID:23765988
Biological Process	GO:0019722	calcium-mediated signaling	CCR6	IMP		Human	PMID:12081481
Biological Process	GO:0060326	cell chemotaxis	CCR6	IDA		Human	PMID:23765988
Biological Process	GO:0006935	chemotaxis	CCR6	IMP		Human	PMID:12081481
Biological Process	GO:0006935	chemotaxis	CCR6	IDA		Human	PMID:20068036
Biological Process	GO:0006935	chemotaxis	Ccr6	IDA		Mouse	MGI:MGI:5784982|PMID:20068036
Biological Process	GO:1904155	DN2 thymocyte differentiation	Ccr6	IMP		Mouse	MGI:MGI:5784970|PMID:24638065
Biological Process	GO:1904156	DN3 thymocyte differentiation	Ccr6	IMP		Mouse	MGI:MGI:5784970|PMID:24638065
Biological Process	GO:0048290	isotype switching to IgA isotypes	Ccr6	IMP		Mouse	MGI:MGI:5787846|PMID:27174992
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Ccr6	IMP		Mouse	MGI:MGI:3820359|PMID:19050256
Biological Process	GO:0072676	lymphocyte migration	Ccr6	IMP		Mouse	MGI:MGI:5787846|PMID:27174992
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ccr6	IMP		Rat	PMID:19233848|RGD:9685141
Biological Process	GO:2000510	positive regulation of dendritic cell chemotaxis	Ccr6	IMP		Rat	PMID:14673014|RGD:9685061
Biological Process	GO:0010634	positive regulation of epithelial cell migration	Ccr6	IDA		Rat	PMID:19233848|RGD:9685141
Biological Process	GO:0060474	positive regulation of flagellated sperm motility involved in capacitation	CCR6	IDA		Human	PMID:23765988
Biological Process	GO:0060474	positive regulation of flagellated sperm motility involved in capacitation	Ccr6	IDA		Mouse	MGI:MGI:5784973|PMID:23765988
Biological Process	GO:2000404	regulation of T cell migration	Ccr6	IMP		Mouse	MGI:MGI:3820359|PMID:19050256
Biological Process	GO:0072678	T cell migration	Ccr6	IDA		Mouse	MGI:MGI:5784970|PMID:24638065
Biological Process	GO:0072679	thymocyte migration	Ccr6	IDA		Mouse	MGI:MGI:5784970|PMID:24638065

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern