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Ccr6 Gene Detail
Summary
  • Symbol
    Ccr6
  • Name
    chemokine (C-C motif) receptor 6
  • Synonyms
    Cmkbr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333797
    NCBI Gene: 12458
  • Gene Overview
    MyGene.info: CCR6
Location & Maps
more
  • Sequence Map
    Chr17:8236043-8257127 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21085 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 4.90 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CCR6, C-C motif chemokine receptor 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CCR6, C-C motif chemokine receptor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKRL3, CKR-L3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
  • Links
    NCBI Gene ID: 1235
    neXtProt AC: NX_P51684

  • Chr Location
    6q27; chr6:167111807-167139141 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    53 phenotypes from 5 alleles in 8 genetic backgrounds
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040899 Ensembl Gene Model | MGI Sequence Detail 21085 C57BL/6J ±  kb
transcript ENSMUST00000167956 Ensembl | MGI Sequence Detail 1219 Not Applicable  
polypeptide ENSMUSP00000128529 Ensembl | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001202 C-C chemokine receptor type 6
  • InterPro Domains
    IPR004067 CC chemokine receptor 6
    IPR000355 Chemokine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 13
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 104
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 68
  • Earliest
    J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
  • Latest
    J:233674 Reboldi A, et al., IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches. Science. 2016 May 13;352(6287):aaf4822

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory