Ccr6
Gene Detail

Symbol Name ID

Ccr6 chemokine (C-C motif) receptor 6 MGI:1333797

Synonyms

Cmkbr6

Feature Type

protein coding gene

Genetic Map

Chromosome 17

4.90 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:8236043-8257127 bp, + strand From Ensembl annotation of GRCm38   21085 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ccr6 ± 2 cM)

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr6

Human ortholog

CCR6 chemokine (C-C motif) receptor 6 NCBI Gene ID 1235
Human Synonyms: BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKRL3, CKR-L3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Human Chr6:167525295-167552629 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	integral to membrane, membrane, ...
Function	C-C chemokine binding, C-C chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (178)    Tissues (77)    Images (30)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	84
In situ reporter (knock in)	56
RT-PCR	38

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(13) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000040899 (Evidence)
Entrez Gene	12458 (Evidence)
UniGene	8007
DFCI	TC1586392, TC1591166
DoTS	DT.101313295, DT.101338575, DT.110564567, DT.110564568, DT.110564570, DT.482538, DT.91391108
NIA Mouse Gene Index	U017466
Consensus CDS Project	CCDS28381.1
International Mouse Knockout Project Status	Ccr6

Sequences

Length	Strain/Species
genomic	ENSMUSG00000040899	Ensembl Gene Model | MGI Sequence Detail	21085	C57BL/6J
transcript	ENSMUST00000164411	Ensembl | MGI Sequence Detail	1553	Not Applicable
polypeptide	ENSMUSP00000131153	Ensembl | MGI Sequence Detail	367	Not Applicable

All sequences(51) RefSeq(14) UniProt(4)

Polymorphisms

SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004067	CC chemokine receptor, type 6
InterPro	IPR000355	Chemokine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001202	C-C chemokine receptor type 6

References

(Earliest) J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
(Latest) J:194093 Kleinschnitz C, et al., Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood. 2013 Jan 24;121(4):679-91
All references(83)