About   Help   FAQ
Ccr6
Gene Detail
 Symbol
Name
ID
Ccr6
chemokine (C-C motif) receptor 6
MGI:1333797
Synonyms Cmkbr6
Feature Type protein coding gene
Genetic Map
Chromosome 17
4.90 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:8236043-8257127 bp, + strand
From Ensembl annotation of GRCm38

  21085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr6

Human
homologs
Human Homolog CCR6, chemokine (C-C motif) receptor 6
NCBI Gene ID 1235
neXtProt AC  NX_P51684
Human Synonyms  BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKRL3, CKR-L3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Human Chr (Location)  6q27; chr6:167111807-167139141 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators.
 
Interactions
Ccr6 interacts with 11 markers (Mir135b, Mir143, Mir320, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chemotaxis, G-protein coupled receptor signaling pathway, ...
Component cell surface, integral component of membrane, ...
Function C-C chemokine receptor activity, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (178)    Tissues (77)    Images (30)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 84
In situ reporter (knock in) 56
RT-PCR 38
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040899 (Evidence)
Entrez Gene12458 (Evidence)
UniGene8007
DFCITC1586392, TC1591166
DoTSDT.101313295, DT.101338575, DT.110564567, DT.110564568, DT.110564570, DT.482538, DT.91391108
NIA Mouse Gene IndexU017466
Consensus CDS ProjectCCDS28381.1
International Mouse Knockout Project StatusCcr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040899 Ensembl Gene Model | MGI Sequence Detail 21085 C57BL/6J ±  kb
transcript ENSMUST00000164411 Ensembl | MGI Sequence Detail 1553 Not Applicable 
polypeptide ENSMUSP00000131153 Ensembl | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(36) UniProt(4)
Polymorphisms SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004067 CC chemokine receptor 6
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001202 C-C chemokine receptor type 6
References (Earliest) J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
(Latest) J:211852 Hajrasouliha AR, et al., Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection. Mol Vis. 2013;19:2517-25
All references(94)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory