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Ccr6
Gene Detail
Symbol

Name
ID
Ccr6
chemokine (C-C motif) receptor 6
MGI:1333797
Synonyms
Cmkbr6
Feature Type
protein coding gene
Genetic Map
Chromosome 17
4.90 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:8236043-8257127 bp, + strand
From Ensembl annotation of GRCm38

  21085 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3214  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr6

Human
homologs
Human Homolog   CCR6, chemokine (C-C motif) receptor 6
NCBI Gene ID 1235
neXtProt AC  NX_P51684
Human Synonyms  BN-1, C-C CKR-6, CC-CKR-6, CCR-6, CD196, CKRL3, CKR-L3, CMKBR6, DCR2, DRY6, GPR29, GPRCY4, STRL22
Human Chr (Location)  6q27; chr6:167111807-167139141 (+)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have decreased inflammatory responses, aberrant trafficking of lymphocytes and dendritic cells, and decreased expression of many inflammatory mediators.
 
Interactions
Ccr6 interacts with 11 markers (Mir135b, Mir143, Mir320, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process chemotaxis, G-protein coupled receptor signaling pathway, ...
Component cell, cell surface, ...
Function C-C chemokine receptor activity, chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (178)    Tissues (77)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 84
In situ reporter (knock in) 56
RT-PCR 38
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000040899 (Evidence)
Entrez Gene12458 (Evidence)
UniGene8007
DFCITC1591166, TC1586392
DoTSDT.110564570, DT.110564568, DT.110564567, DT.101338575, DT.101313295, DT.91391108, DT.482538
NIA Mouse Gene IndexU017466
Consensus CDS ProjectCCDS28381.1
International Mouse Knockout Project StatusCcr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040899 Ensembl Gene Model | MGI Sequence Detail 21085 C57BL/6J ±  kb
transcript ENSMUST00000167956 Ensembl | MGI Sequence Detail 1219 Not Applicable 
polypeptide ENSMUSP00000128529 Ensembl | MGI Sequence Detail 367 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(38) UniProt(4)
Polymorphisms
SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004067 CC chemokine receptor 6
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001202 C-C chemokine receptor type 6
References
(Earliest) J:40322 Nibbs RJB, et al., Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5. J Biol Chem. 1997 May 9;272(19):12495-504
(Latest) J:216494 Nandi B, et al., CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis. PLoS One. 2014;9(5):e97566
All references(98)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory