Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes CARMIL1
  • Mouse genes Carmil1
  • Rat genes Carmil1
  • Zfish genes carmil1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Carmil1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	CARMIL1	IPI	UniProtKB:O75962	Human	PMID:19846667
Molecular Function	GO:0005515	protein binding	CARMIL1	IPI	UniProtKB:Q12965	Human	PMID:19846667
Molecular Function	GO:0044877	protein-containing complex binding	CARMIL1	IDA		Human	PMID:16054028
Molecular Function	GO:0044877	protein-containing complex binding	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Cellular Component	GO:0031252	cell leading edge	CARMIL1	IDA		Human	PMID:19846667
Cellular Component	GO:0005829	cytosol	CARMIL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	CARMIL1	HDA		Human	PMID:19199708
Cellular Component	GO:0031941	filamentous actin	Carmil1	IDA		Mouse	MGI:MGI:3588909|PMID:16054028
Cellular Component	GO:0030027	lamellipodium	CARMIL1	IDA		Human	PMID:19846667
Cellular Component	GO:0030027	lamellipodium	Carmil1	IDA		Mouse	MGI:MGI:3588909|PMID:16054028
Cellular Component	GO:0044354	macropinosome	CARMIL1	IDA		Human	PMID:19846667
Cellular Component	GO:0016607	nuclear speck	CARMIL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	CARMIL1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	CARMIL1	IDA		Human	PMID:26578515
Biological Process	GO:0051639	actin filament network formation	CARMIL1	IDA		Human	PMID:19846667
Biological Process	GO:0051638	barbed-end actin filament uncapping	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:0016477	cell migration	CARMIL1	IMP		Human	PMID:19846667
Biological Process	GO:0030032	lamellipodium assembly	CARMIL1	IMP		Human	PMID:19846667
Biological Process	GO:0044351	macropinocytosis	CARMIL1	IDA		Human	PMID:19846667
Biological Process	GO:2000813	negative regulation of barbed-end actin filament capping	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:0030335	positive regulation of cell migration	CARMIL1	IMP		Human	PMID:16054028
Biological Process	GO:0030335	positive regulation of cell migration	CARMIL1	IDA		Human	PMID:19846667
Biological Process	GO:0030335	positive regulation of cell migration	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:1902745	positive regulation of lamellipodium organization	CARMIL1	IDA		Human	PMID:16054028
Biological Process	GO:1902745	positive regulation of lamellipodium organization	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:0051496	positive regulation of stress fiber assembly	CARMIL1	IMP		Human	PMID:16054028
Biological Process	GO:0051496	positive regulation of stress fiber assembly	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	CARMIL1	IMP		Human	PMID:16054028
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Carmil1	IMP		Mouse	MGI:MGI:3588909|PMID:16054028
Biological Process	GO:0031529	ruffle organization	CARMIL1	IMP		Human	PMID:19846667
Biological Process	GO:0046415	urate metabolic process	CARMIL1	IMP		Human	PMID:19503597
Biological Process	GO:0046415	urate metabolic process	CARMIL1	IMP		Human	PMID:24318514

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern