Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes BUB1
  • Mouse genes Bub1
  • Rat genes Bub1
  • Zfish genes bub1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bub1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O43684	Human	PMID:10198256
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:P03070	Human	PMID:14732683
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O43684	Human	PMID:15525512
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O95376	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:P46108	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:P53350	Human	PMID:16760428
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:Q8NG31	Human	PMID:17981135
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:Q8NG31-2	Human	PMID:19141287
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O60566	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:Q8NG31	Human	PMID:20360068
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O43684	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:Q8NG31	Human	PMID:22660415
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O43684	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O60566	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O43684	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:Q8NG31-2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:Q8NG31-2	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O60566	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O95376	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:O95376	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	BUB1	IPI	UniProtKB:P46108	Human	PMID:35044719
Cellular Component	GO:0000775	chromosome, centromeric region	Bub1	IDA		Mouse	PMID:12355205
Cellular Component	GO:0000779	condensed chromosome, centromeric region	Bub1	IDA		Mouse	PMID:18084284
Cellular Component	GO:0000779	condensed chromosome, centromeric region	Bub1	IDA		Mouse	PMID:19965387
Cellular Component	GO:0005829	cytosol	BUB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	BUB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000776	kinetochore	BUB1	IDA		Human	PMID:15020684
Cellular Component	GO:0000776	kinetochore	BUB1	IDA		Human	PMID:16760428
Cellular Component	GO:0000776	kinetochore	BUB1	IDA		Human	PMID:17227893
Cellular Component	GO:0000776	kinetochore	BUB1	IDA		Human	PMID:19465021
Cellular Component	GO:0000776	kinetochore	BUB1	IDA		Human	PMID:22331848
Cellular Component	GO:0000776	kinetochore	Bub1	IDA		Mouse	PMID:15226446
Cellular Component	GO:0000776	kinetochore	Bub1	IDA		Mouse	PMID:17938250
Cellular Component	GO:0000776	kinetochore	Bub1	IDA		Mouse	PMID:17227893
Cellular Component	GO:0016020	membrane	BUB1	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	BUB1	IDA		Human	GO_REF:0000052
Biological Process	GO:0008283	cell population proliferation	Bub1	IEP		Rat	PMID:9441741|RGD:2326104
Biological Process	GO:0007059	chromosome segregation	Bub1	IMP	MGI:MGI:3793294	Mouse	PMID:17938250
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	Bub1	IMP	MGI:MGI:3793294	Mouse	PMID:17938250
Biological Process	GO:0071174	mitotic spindle checkpoint signaling	Bub1	IMP	MGI:MGI:3793294	Mouse	PMID:17938250
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Bub1	IMP	MGI:MGI:3793294	Mouse	PMID:17938250
Biological Process	GO:0051983	regulation of chromosome segregation	BUB1	IMP		Human	PMID:19487456
Biological Process	GO:0007063	regulation of sister chromatid cohesion	BUB1	IDA		Human	PMID:15723797

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern