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Bub1 Gene Detail
Summary
  • Symbol
    Bub1
  • Name
    BUB1, mitotic checkpoint serine/threonine kinase
  • Synonyms
    Bub1a, D2Xrf87
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100510
    NCBI Gene: 12235
  • Gene Overview
    MyGene.info: BUB1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:127801122-127831865 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100510
protein coding gene Chr2:127800197-127831865 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026469
protein coding gene Chr2:131084832-131119532 (-)
A/J MGP_AJ_G0026433
protein coding gene Chr2:125783159-125814061 (-)
AKR/J MGP_AKRJ_G0026408
protein coding gene Chr2:129384073-129415523 (-)
BALB/cJ MGP_BALBcJ_G0026445
protein coding gene Chr2:126049485-126080765 (-)
C3H/HeJ MGP_C3HHeJ_G0026188
protein coding gene Chr2:129880247-129912428 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026890
protein coding gene Chr2:135211724-135243998 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024267
protein coding gene Chr2:120620684-120651369 (-)
CAST/EiJ MGP_CASTEiJ_G0025649
protein coding gene Chr2:130090665-130123606 (-)
CBA/J MGP_CBAJ_G0026168
protein coding gene Chr2:140212632-140251922 (-)
DBA/2J MGP_DBA2J_G0026302
protein coding gene Chr2:125182521-125214404 (-)
FVB/NJ MGP_FVBNJ_G0026266
protein coding gene Chr2:123841766-123873013 (-)
LP/J MGP_LPJ_G0026407
protein coding gene Chr2:131336985-131370163 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026286
protein coding gene Chr2:144218997-144254573 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026945
protein coding gene Chr2:129393908-129424800 (-)
PWK/PhJ MGP_PWKPhJ_G0025385
protein coding gene Chr2:124749927-124781680 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025187
protein coding gene Chr2:128485636-128521584 (-)
WSB/EiJ MGP_WSBEiJ_G0025723
protein coding gene Chr2:130300095-130332533 (-)



Homology
more
  • Human Ortholog
    BUB1, BUB1 mitotic checkpoint serine/threonine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BUB1, BUB1 mitotic checkpoint serine/threonine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BUB1A, BUB1L, hBUB1
  • Links
    NCBI Gene ID: 699
    neXtProt AC: NX_O43683
    UniProt: O43683

  • Chr Location
    2q13; chr2:110637698-110678107 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37910
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BUB1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 9 alleles in 9 genetic backgrounds
    3 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit embryonic lethality prior to implantation. Mice homozygous for a kinase dead allele exhibit aneuploidy in somatic and germ cells and reduced male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027379 Ensembl Gene Model | MGI Sequence Detail 30744 C57BL/6J ±  kb
    transcript ENSMUST00000028858 Ensembl | MGI Sequence Detail 3421 Not Applicable  
    polypeptide ENSMUSP00000028858 Ensembl | MGI Sequence Detail 1059 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-32317, MGI:105276, MGI:2139128, MGI:2139498
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 9
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory