Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Bok

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes BOK
- Mouse genes Bok
- Rat genes Bok
- Zfish genes boka,bokb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Bok

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051400	BH domain binding	Bok	IPI	RGD:620525	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0051400	BH domain binding	Bok	IPI	RGD:620621	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:Q12983	Human	PMID:15868100
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:Q14643	Human	PMID:23884412
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:P10809	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:P13637	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:P50570-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:Q86V38	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	BOK	IPI	UniProtKB:Q8TB36	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Bok	IPI	UniProtKB:P11881	Mouse	MGI:MGI:5790897\|PMID:27053113
Molecular Function	GO:0005515	protein binding	Bok	IPI	UniProtKB:Q63269	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0005515	protein binding	Bok	IPI	UniProtKB:P11881\|UniProtKB:P11881\|UniProtKB:P70227	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0005515	protein binding	Bok	IPI	UniProtKB:Q9Z1P3	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0046983	protein dimerization activity	Bok	IPI	UniProtKB:Q9Z1P3	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0046982	protein heterodimerization activity	Bok	IDA		Rat	PMID:9804769\|RGD:11535101
Molecular Function	GO:0042803	protein homodimerization activity	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Molecular Function	GO:0044877	protein-containing complex binding	Bok	IPI	RGD:620525	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0044877	protein-containing complex binding	Bok	IPI	RGD:620621	Rat	PMID:9356461\|RGD:70678
Molecular Function	GO:0005102	signaling receptor binding	Bok	IPI	UniProtKB:P29995	Mouse	MGI:MGI:5527223\|PMID:23884412
Molecular Function	GO:0031625	ubiquitin protein ligase binding	Bok	IPI	UniProtKB:Q9R049	Mouse	MGI:MGI:5796067\|PMID:26949185
Cellular Component	GO:0033106	cis-Golgi network membrane	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Cellular Component	GO:0005737	cytoplasm	BOK	IDA		Human	PMID:15868100
Cellular Component	GO:0005737	cytoplasm	BOK	IDA		Human	PMID:16302269
Cellular Component	GO:0005737	cytoplasm	BOK	IDA		Human	PMID:19942931
Cellular Component	GO:0005737	cytoplasm	BOK	IDA		Human	PMID:20673843
Cellular Component	GO:0031901	early endosome membrane	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Cellular Component	GO:0005783	endoplasmic reticulum	BOK	IDA		Human	PMID:16302269
Cellular Component	GO:0005789	endoplasmic reticulum membrane	BOK	IDA		Human	PMID:27505430
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Bok	IDA		Mouse	MGI:MGI:5796067\|PMID:26949185
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Cellular Component	GO:0005794	Golgi apparatus	BOK	IDA		Human	PMID:27505430
Cellular Component	GO:0005743	mitochondrial inner membrane	BOK	IDA		Human	PMID:24113155
Cellular Component	GO:0031966	mitochondrial membrane	BOK	IDA		Human	PMID:15868100
Cellular Component	GO:0031966	mitochondrial membrane	BOK	IDA		Human	PMID:27505430
Cellular Component	GO:0031966	mitochondrial membrane	Bok	IDA		Mouse	MGI:MGI:5796067\|PMID:26949185
Cellular Component	GO:0031966	mitochondrial membrane	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Cellular Component	GO:0005739	mitochondrion	BOK	IDA		Human	PMID:15102863
Cellular Component	GO:0005739	mitochondrion	BOK	IDA		Human	PMID:19095301
Cellular Component	GO:0005739	mitochondrion	BOK	IDA		Human	PMID:19942931
Cellular Component	GO:0005739	mitochondrion	Bok	IDA		Rat	PMID:18058945\|RGD:5128576
Cellular Component	GO:0005634	nucleus	BOK	IDA		Human	PMID:16302269
Cellular Component	GO:0005634	nucleus	BOK	IDA		Human	PMID:19095301
Cellular Component	GO:0005634	nucleus	BOK	IDA		Human	PMID:20673843
Cellular Component	GO:0055038	recycling endosome membrane	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Cellular Component	GO:0032588	trans-Golgi network membrane	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	BOK	IMP		Human	PMID:20673843
Biological Process	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	Bok	IMP		Mouse	MGI:MGI:5648772\|PMID:26015568
Biological Process	GO:0006915	apoptotic process	BOK	IDA		Human	PMID:15102863
Biological Process	GO:0006915	apoptotic process	Bok	IDA		Rat	PMID:9356461\|RGD:70678
Biological Process	GO:0006915	apoptotic process	Bok	IMP		Rat	PMID:9356461\|RGD:70678
Biological Process	GO:0007420	brain development	Bok	IEP		Rat	PMID:18058945\|RGD:5128576
Biological Process	GO:0006921	cellular component disassembly involved in execution phase of apoptosis	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	BOK	IMP		Human	PMID:15102863
Biological Process	GO:0008584	male gonad development	Bok	IEP		Rat	PMID:11720903\|RGD:5128577
Biological Process	GO:0051902	negative regulation of mitochondrial depolarization	Bok	IMP		Mouse	MGI:MGI:5796062\|PMID:27098698
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Bok	IMP		Mouse	MGI:MGI:5796062\|PMID:27098698
Biological Process	GO:0060546	negative regulation of necroptotic process	Bok	IMP		Mouse	MGI:MGI:5796062\|PMID:27098698
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Bok	IMP		Mouse	MGI:MGI:5796062\|PMID:27098698
Biological Process	GO:0051402	neuron apoptotic process	Bok	IDA		Mouse	PMID:9535847
Biological Process	GO:0048709	oligodendrocyte differentiation	Bok	IEP		Rat	PMID:12787069\|RGD:631874
Biological Process	GO:0043065	positive regulation of apoptotic process	BOK	IDA		Human	PMID:16302269
Biological Process	GO:0043065	positive regulation of apoptotic process	BOK	IDA		Human	PMID:27505430
Biological Process	GO:0043065	positive regulation of apoptotic process	Bok	IDA		Rat	PMID:9356461\|RGD:70678
Biological Process	GO:0043065	positive regulation of apoptotic process	Bok	IDA		Rat	PMID:9804769\|RGD:11535101
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Bok	IMP		Mouse	MGI:MGI:5648772\|PMID:26015568
Biological Process	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	Bok	IDA		Mouse	MGI:MGI:5796067\|PMID:26949185
Biological Process	GO:1900119	positive regulation of execution phase of apoptosis	BOK	IMP		Human	PMID:20673843
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Bok	IDA		Mouse	MGI:MGI:5705719\|PMID:23429263
Biological Process	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	Bok	IDA		Mouse	MGI:MGI:5796067\|PMID:26949185
Biological Process	GO:1903899	positive regulation of PERK-mediated unfolded protein response	Bok	IMP		Mouse	MGI:MGI:5648772\|PMID:26015568
Biological Process	GO:0051259	protein complex oligomerization	Bok	IDA		Mouse	MGI:MGI:5796067\|PMID:26949185
Biological Process	GO:0010506	regulation of autophagy	BOK	IMP		Human	PMID:24113155
Biological Process	GO:1901382	regulation of chorionic trophoblast cell proliferation	BOK	IDA		Human	PMID:19942931
Biological Process	GO:0051480	regulation of cytosolic calcium ion concentration	Bok	IMP		Mouse	MGI:MGI:5796062\|PMID:27098698
Biological Process	GO:1904708	regulation of granulosa cell apoptotic process	BOK	IMP		Human	PMID:20673843
Biological Process	GO:0001836	release of cytochrome c from mitochondria	BOK	IDA		Human	PMID:27505430

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.